Rabeprazole
- CAS NO.:117976-89-3
- Empirical Formula: C18H21N3O3S
- Molecular Weight: 359.44
- MDL number: MFCD00868879
- EINECS: 601-501-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-17 11:35:48
What is Rabeprazole?
Absorption
Absolute bioavailability is approximately 52%.
The Uses of Rabeprazole
Rabeprazole is used to treat hyperacidity. It is a proton pump inhibitor that helps heal gastrointestinal ulcers, treats gastroesophageal reflux disease, and also treats hypersecretory disorders.
Indications
For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
Background
Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
What are the applications of Application
Rabeprazole is a proton pump ATP-ase inhibitor
Pharmacokinetics
Rabeprazole prevents the production of acid in the stomach. It reduces symptoms and prevents injury to the esophagus or stomach in patients with gastroesophageal reflux disease (GERD) or ulcers. Rabeprazole is also useful in conditions that produce too much stomach acid such as Zollinger-Ellison syndrome. Rabeprazole may also be used with antibiotics to get rid of bacteria that are associated with some ulcers. Rabeprazole is a selective and irreversible proton pump inhibitor, suppresses gastric acid secretion by specific inhibition of the H+, K+ -ATPase, which is found at the secretory surface of parietal cells. In doing so, it inhibits the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen.
Metabolism
Hepatic
Properties of Rabeprazole
Melting point: | 99-100° (dec) |
Boiling point: | 603.9±65.0 °C(Predicted) |
Density | 1.33±0.1 g/cm3(Predicted) |
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
color | Light Brown to Very Dark Brown |
Safety information for Rabeprazole
Computed Descriptors for Rabeprazole
Abamectin manufacturer
SGMR PHARMACEUTICALS PVT LTD
TYNDAL LABS PVT LTD
Synaptics Labs Private Limited
Sainor Life Sciences Pvt Ltd
Indo Rama Pharma
Ralington Pharma
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