Rebeprazole sodium
Synonym(s):2-([4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole;Pariprazole;Rabeprazole sodium
- CAS NO.:117976-90-6
- Empirical Formula: C18H20N3NaO3S
- Molecular Weight: 381.42
- MDL number: MFCD02092688
- EINECS: 629-730-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-16 07:03:48
What is Rebeprazole sodium?
Description
Rebeprazole sodium was launched as Pariet in Japan, its first market, for the treatment of peptic ulcers including gastric and duodenal ulcers. From 4-chloro- 2,3-dimethylpyridine N-oxide, a six step synthesis allows access to the basic skeleton after successive condensations. Rabeprazole, a structural analog of Omeprazole, the first compound to have been marketed in this class up to now, is reported to be a more potent inhibitor of gastric H+/K+-adenosine triphosphate (ATPase) ; a common mechanism of action of this chemical class involves the conversion at low pH to a reactive sulphonamide that itself binds to cysteine residues located on the enzyme. Moreover, rabeprazole showed an antibacterial activity against Helicobacter Pylori, with a MIC90 of 1.56 μg/ml.
Rebeprazole sodium has a faster onset of action compared with omeprazole, but a shorter duration of action, being extensively and rapidly metabolized in several animal species. In clinical studies in patients with gastric ulcers, 10 and 20 mg rabeprazole sodium once-daily significantly inhibited basal and stimulated acid output. Rabeprazole is awaiting registration in the US for treatment of gastrooesophageal reflux disease (GORD) and other pathologic hypersecretory conditions including Zollinger-Ellison syndrome.
The Uses of Rebeprazole sodium
Rebeprazole sodium is a partially reversible gastric proton pump inhibitor
What are the applications of Application
Rabeprazole Sodium Salt is a proton pump inhibitor
Properties of Rebeprazole sodium
Melting point: | 140-141°C dec. |
storage temp. | -20°C |
solubility | H2O: soluble10mg/mL (clear solution) |
form | powder |
color | white to beige |
Safety information for Rebeprazole sodium
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H413:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for Rebeprazole sodium
InChIKey | KRCQSTCYZUOBHN-UHFFFAOYSA-N |
Abamectin manufacturer
Jigs Chemical ltd
Cadila Pharmaceuticals Ltd
AVD pharmaceuticals Pvt Ltd
Micro Orgo Chem
Dr. Reddy's Laboratories Ltd
KARPSCHEM LABORATORIES PVT. LTD.
SOLISOM HEALTHCARE LLP
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