Naftopidil dihydrochloride
Synonym(s):4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride hydrate;KT-611
- CAS NO.:57149-07-2
- Empirical Formula: C24H28N2O3
- Molecular Weight: 392.49
- MDL number: MFCD00153845
- EINECS: 692-531-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 18:15:48
What is Naftopidil dihydrochloride?
Description
Naftopidil was launched in Japan for the treatment of dysuria associated with benign prostatic hypertrophy (BPH). It can be prepared by a two step route starting with α-naphthol. Naftopidil is a potent postsynaptic-selective alpha-l-antagonist with a slightly higher affinity for the human prostatic than for the aortic alpha-adrenoceptor. It also shows a 5-HT1A agonistic effect, as well as a weak calcium antagonistic activity, but no alpha-2 or beta-adrenoreceptor affinity. In experiments with rats or rabbits, Naftopidil was shown to be more potent and selective for the urodynamic effect than the hypotensive effect. Aromatic or aliphatic hydroxylation are the major routes of metabolism, producing metabolites with a profile similar to the parent compound.
Chemical properties
Off-White Solid
Originator
Boehringer Mannheim (Germany)
The Uses of Naftopidil dihydrochloride
A α-1-Adrenergic receptor antagonist, antihypertensive.
The Uses of Naftopidil dihydrochloride
antihypertensive, alpha-blocker, 5HT1a agonist
The Uses of Naftopidil dihydrochloride
Naftopidil is an α-1-adrenergic receptor antagonist. Naftopidil is used as an antihypertensive.
What are the applications of Application
Naftopidil is N α-1-Adrenergic receptor antagonist and an antihypertensive.
Definition
ChEBI: Naftopidil is a member of piperazines.
brand name
Avishot;Flivas
Biological Activity
An α 1 -adrenoceptor antagonist with only weak antagonism at post-junctional α 2 receptors; a potent, persistent antihypertensive and vasodilator.
Properties of Naftopidil dihydrochloride
Melting point: | 127 °C |
Boiling point: | 517.2°C (rough estimate) |
Density | 1.1592 (rough estimate) |
refractive index | 1.6300 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | methanol: >10 mg/mL |
form | solid |
pka | 14.01±0.20(Predicted) |
color | white |
Merck | 14,6356 |
CAS DataBase Reference | 57149-07-2(CAS DataBase Reference) |
Safety information for Naftopidil dihydrochloride
Computed Descriptors for Naftopidil dihydrochloride
Abamectin manufacturer
Trimax bio sciences private ltd
New Products
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