4-dimethylaminoazobenzene SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： 4-dimethylaminoazobenzene
- CAS： 60-11-7
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Carcinogenicity, Category 2
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H301 Toxic if swallowed
H351 Suspected of causing cancer
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: 4-dimethylaminoazobenzene
- Common names and synonyms: 4-dimethylaminoazobenzene
- CAS number: 60-11-7
- EC number: 200-455-7
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest.
Remove contaminated clothes. Rinse and then wash skin with water and soap.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Give one or two glasses of water to drink.
Most important symptoms/effects, acute and delayed
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Enlarged liver; liver, kidney disturbance; contact dermatitis; cough, wheezing, dyspnea (breathing difficulty); bloody sputum; bronchial secretions; frequent urination, hematuria (blood in the urine), dysuria; [potential occupational carcinogen] Target Organs: Skin, respiratory system, liver, kidneys, bladder (NIOSH, 2016)
Indication of immediate medical attention and special treatment needed, if necessary
More than half of bound dye in all liver-cell fractions is assoc with sol proteins; of this, 80% is bound to fraction which accounts for only 15% of sol proteins.
SECTION 5: Firefighting measures
Suitable extinguishing media
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
Specific hazards arising from the chemical
Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)
Special protective actions for fire-fighters
In case of fire in the surroundings, use appropriate extinguishing media.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.
Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.
Methods and materials for containment and cleaning up
PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms . Filter housing that is designed so that used filters can be transferred into plastic bags without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal . The plastic bag should be sealed immediately . The sealed bag should be labelled properly . Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bags, so that outer surface ... is not contaminated . The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. Chemical Carcinogens
SECTION 7: Handling and storage
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired . Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens
SECTION 8: Exposure controls/personal protection
Control parameters
| Component | 4-dimethylaminoazobenzene |
|---|---|
| CAS No. | 60-11-7 |
|
NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concn. NIOSH considers 4-dimethylaminoazobenzene to be a potential occupational carcinogen. |
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety goggles or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation, local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
PHYSICAL DESCRIPTION: Yellow crystalline leaflets or an orange powder. (NTP, 1992)
-
Colour：
YELLOW CRYSTALLINE LEAFLETS
-
Odour：
no data available
-
Melting point/freezing point：
295°C(dec.)(lit.)
-
Boiling point or initial boiling point and boiling range：
193°C(lit.)
-
Flammability：
Not combustible.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
170°C(lit.)
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
no data available
-
Solubility：
less than 1 mg/mL at 72° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
log Kow= 4.58
-
Vapour pressure：
3e-07 mm Hg (est.) (NIOSH, 2016)
-
Density and/or relative density：
1.027g/cm3
-
Relative vapour density：
7.78 (NTP, 1992) (Relative to Air)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
NIOSH considers 4-dimethylaminoazobenzene to be a potential occupational carcinogen.
Decomposes on heating. This produces nitrogen oxides.
Chemical stability
no data available
Possibility of hazardous reactions
4-DIMETHYLAMINOAZOBENZENE can detonate, particularly if sensitized by the presence of metal salts or strong acids. May form toxic gases with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. May form flammable gases with alkali metals. May react explosively with strong oxidizing agents, metal salts, peroxides, and sulfides. May react explosively with strong oxidizing agents, metal salts, peroxides, and sulfides.
Conditions to avoid
no data available
Incompatible materials
STABILITY: This chemical is sensitive to heat and light. Solutions of this chemical in water, DMSO, 95% ethanol or acetone should be stable for 24 hours under normal lab conditions.REACTIVITY: This chemical is incompatible with strong oxidizing agents and strong acids. (NTP, 1992)
Hazardous decomposition products
no data available
SECTION 11: Toxicological information
Acute toxicity
- Oral: no data available
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
The Human Health Assessment Group in EPA's Office of Health and Environmental Assessment has evaluated dimethylaminoazobenzene for carcinogenicity. According to their analysis, the weight-of-evidence for dimethylaminoazobenzene is group B2, which is based on no evidence in humans and sufficient evidence in animals. As a group B2 chemical, dimethylaminoazobenzene is considered to be probably carcinogenic to humans.
Reproductive toxicity
No information is available on the reproductive or developmental effects of 4-dimethylaminoazobenzene in humans. Animal studies have reported birth defects in the offspring of mice exposed to 4-dimethylaminoazobenzene.
STOT-single exposure
The substance is irritating to the eyes, skin and respiratory tract.
STOT-repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. This substance is possibly carcinogenic to humans.
Aspiration hazard
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
Recovery of 0.29 ppm N,N-dimethyl-p-(phenylazo)aniline incubated with an original culture of settled domestic wastewater after 7 days was at trace levels and it was not detected following 1st, 2nd, and 3rd subcultures after 7 days each(1).
Bioaccumulative potential
Using a reported log octanol/water partition coefficient of 4.58(1), an estimated BCF of 1780 was calculated(2,SRC). Based on this estimated BCF, N,N-dimethyl-p-(phenylazo)aniline should bioconcentrate in aquatic organisms(SRC).
Mobility in soil
Using a reported log octanol/water partition coefficient of 4.58(1), an estimated Koc of 7390 was calculated(2,SRC). Based on this estimated Koc, N,N-dimethyl-p-(phenylazo)aniline should adsorb to soils and sediment. Since N,N-dimethyl-p-(phenylazo)aniline has a pKa of 3.226 at 25 deg C(3), and it exists partially as a cation, the extent of its adsorption to soils and sediments may be affected by the pH of the medium.
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN2811 (For reference only, please check.)
IMDG: UN2811 (For reference only, please check.)
IATA: UN2811 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)
IMDG: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)
IATA: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/