(2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno[3,4-b]furo[2,3-h]chromen-6-one SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： (2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno[3,4-b]furo[2,3-h]chromen-6-one
- CAS： 83-79-4
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity – single exposure, Category 3
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H301 Toxic if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H410 Very toxic to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
P391 Collect spillage.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: (2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno[3,4-b]furo[2,3-h]chromen-6-one
- Common names and synonyms: (2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno[3,4-b]furo[2,3-h]chromen-6-one
- CAS number: 83-79-4
- EC number: 201-501-9
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Artificial respiration may be needed.
First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Rinse and then wash skin with water and soap.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Give a slurry of activated charcoal in water to drink. Rest. Refer for medical attention .
Most important symptoms/effects, acute and delayed
Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, respiratory system; numb mucous membrane; nausea, vomiting, abdominal pain; muscle tremor, incoordination, clonic convulsions, stupor Target Organs: Eyes, skin, respiratory system, central nervous system (NIOSH, 2016)
Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Rotenone and related compounds
SECTION 5: Firefighting measures
Suitable extinguishing media
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)
Specific hazards arising from the chemical
Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Special protective actions for fire-fighters
Use water spray, powder, alcohol-resistant foam, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered air-tight containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Sweep spilled substance into covered air-tight containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: P3 filter respirator for toxic particles. Do NOT let this chemical enter the environment.
Methods and materials for containment and cleaning up
1. Ventilate area of spill. 2. For small quantities, sweep onto paper or other suitable material, place in an appropriate container and burn in a safe place (such as a fume hood). Large quantities can be reclaimed; however, if this is not practical, dissolve in a flammable solvent (such as alc) and atomize in a suitable combustion chamber.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from food and feedstuffs. Well closed.Store only in original containers, in a dry place inaccessible to children and pets. 7.4% Rotenone Wettable Powder
SECTION 8: Exposure controls/personal protection
Control parameters
TLV: 5 mg/m3, as TWA; A4 (not classifiable as a human carcinogen).MAK: skin absorption (H)
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety goggles or eye protection in combination with breathing protection if powder.
Protective gloves.
Use local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
PHYSICAL DESCRIPTION: Colorless to brownish crystals or a white to brownish-white crystalline powder. Has neither odor nor taste. (NTP, 1992)
-
Colour：
Orthorhombic, six-sided plates from trichloroethylene
-
Odour：
Odorless
-
Melting point/freezing point：
159-164°C
-
Boiling point or initial boiling point and boiling range：
210-220°C (0.5 mmHg)
-
Flammability：
Combustible Solid
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
no data available
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
no data available
-
Solubility：
less than 1 mg/mL at 68° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
log Kow = 4.10
-
Vapour pressure：
less than 0.0075 mm Hg at 68° F (NTP, 1992)
-
Density and/or relative density：
1.27(20°C)
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on burning. This produces irritating fumes.
Chemical stability
Decomp upon exposure to light and air. Colorless solutions in organic solvents oxidize upon exposure and become yellow, orange and then deep red and may deposit crystals of dehydrorotenone and rotenonone which are toxic to insects.
Possibility of hazardous reactions
Flammable if preheated.ROTENONE is readily oxidized in the presence of alkalis. It is incompatible with oxidizers. (NTP, 1992).
Conditions to avoid
no data available
Incompatible materials
Strong oxidizers, alkalis.
Hazardous decomposition products
When heated to decomposition it emits acrid smoke and irritating fumes.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rabbit oral 1500 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Cancer Classification: Group E Evidence of Non-carcinogenicity for Humans
Reproductive toxicity
no data available
STOT-single exposure
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. This may result in convulsions and respiratory depression.
STOT-repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the kidneys and liver.
Aspiration hazard
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill) weight 1-1.5 g; Conditions: freshwater, static, 12 deg C, pH 8.0, hardness 300 mg/L CaCO3, alkalinity 225-245 mg/L CaCO3, dissolved oxygen >60%; Concentration: 138 ug/L for 24 hr (95% confidence interval: 125-152 ug/L) /5% purity emulsifiable concentrate
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea) age <24 hr; Conditions: freshwater, static; Concentration: 27.5 ug/L for 24 hr (95% confidence interval: 23.9-31.6 ug/L); Effect: intoxication, immobilization /formulation
- Toxicity to algae: EC50; Species: Scenedesmus subspicatus (Green Algae); Conditions: freshwater, static; Concentration: 240000 ug/L for 49-79 min; Effect: decreased population photosynthesis /100% purity
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: In southern Italy, two types of soil samples spiked with rotenone, a silt clay loam and a loamy soil, underwent degradation experiments in dark conditions at 10-20 deg C. The results indicated that half-life values for rotenone were 8 days in the silt clay loam soil and 5 days in the loamy soil at 20 deg C. At 10 deg C however, the half-lives were 25 days for silt clay loam soil and 21 for the loamy soil(1). Rotenone is listed as one of the organic substances which may be degraded during aerobic and anaerobic sewage treatment if adequate acclimatization can be achieved; much depends on the concentration to be treated and possibly on the temperature during treatment(2).
Bioaccumulative potential
A study showed that when yearling bluegills (Lepomis macrochirus) were exposed to 5.2 ug/L of rotenone for 30 days in a continuous flow system, bioconcentration factors for the head, viscera, and carcass were 165, 3,500, and 125, respectively(4). According to a classification scheme(3), bioconcentation factors of 100-100 are high and >1000 are very high(SRC).
Mobility in soil
The Koc of rotenone is estimated as approximately 3,200(SRC), using a measured log Kow of 4.10(1) and a regression-derived equation(2). According to a recommended classification scheme(3), this estimated Koc value suggests that rotenone is expected to have slight mobility in soil(SRC). The Kd values of rotenone were determined in 2 different soil types from Southern Italy. In the adsorption experiment Kd values were 0.56 and 2.73 L/kg for silt clay loam and loamy soil respectively, and the degradation rates were 0.102 and 0.074 d-1 for soils at 20 deg C(4).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN2811 (For reference only, please check.)
IMDG: UN2811 (For reference only, please check.)
IATA: UN2811 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)
IMDG: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)
IATA: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
The substance is combustible but no flash point is available in literature.Carrier solvents used in commercial formulations may change physical and toxicological properties.Depending on the degree of exposure, periodic medical examination is suggested.