Quinoline SDS

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Dermal

Skin irritation, Category 2

Eye irritation, Category 2

Germ cell mutagenicity, Category 2

Carcinogenicity, Category 1B

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

H302 Harmful if swallowed

H312 Harmful in contact with skin

H315 Causes skin irritation

H319 Causes serious eye irritation

H341 Suspected of causing genetic defects

H350 May cause cancer

H411 Toxic to aquatic life with long lasting effects

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P203 Obtain, read and follow all safety instructions before use.

P273 Avoid release to the environment.

P301+P317 IF SWALLOWED: Get medical help.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P317 Get medical help.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P332+P317 If skin irritation occurs: Get medical help.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P318 IF exposed or concerned, get medical advice.

P391 Collect spillage.

P405 Store locked up.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

Vapors are irritating to nose and throat and may cause headaches, dizziness, and nausea if inhaled. Ingestion causes irritation of mouth and stomach; vomiting may occur. Contact with eyes or skin causes irritation. (USCG, 1999)

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Monitor for shock and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal . Aromatic hydrocarbons and related compounds

Extinguish with water, dry chemicals, foam, or carbon dioxide.

Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fires. Behavior in Fire: Heat exposure may cause pressure build-up in closed containers. (USCG, 1999)

Use water spray, foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Spread over with the 9:1 mixture of sand and soda ash. After mixing, transfer into a paper carton, stuffed with ruffled paper.

NO open flames. Above 101°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Provision to contain effluent from fire extinguishing. Separated from strong oxidants, acids, acid anhydrides and food and feedstuffs. Dry. Keep in the dark. Well closed. Store in an area without drain or sewer access.PROTECT FROM LIGHT & MOISTURE.

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear safety spectacles.

Protective gloves. Protective clothing.

Use ventilation, local exhaust or breathing protection.

no data available

Decomposes on heating and on burning. This produces toxic fumes including nitrogen oxides. Reacts with strong oxidants, acids and anhydrides.

Darkens on storage in ordinary, stoppered bottle

IT IS MODERATELY FLAMMABLE BUT DOES NOT EVOLVE A FLAMMABLE CONCN OF VAPOR AT TEMP OF BELOW 99 DEG C.QUINOLINE is hygroscopic. It absorbs as much as 22% water. It is sensitive to light and moisture. It darkens on storage. This chemical is a weak base. A potentially explosive reaction may occur with hydrogen peroxide. It reacts violently with dinitrogen tetraoxide. It also reacts violently with perchromates. It is incompatible with (linseed oil + thionyl chloride) and maleic anhydride. It is also incompatible with strong oxidizers and strong acids. This chemical can be unpredictably violent. It dissolves sulfur, phosphorus and arsenic trioxide. It may attack some forms of plastics. It is a preparative hazard. (NTP, 1992)

no data available

Violent reaction with dinitrogen tetraoxide; perchromates.

When heated to decomposition it emits toxic fumes of /nitrogen oxides/.

no data available

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No information is available on the reproductive or developmental effects of quinoline in humans or animals.

The substance is irritating to the eyes and skin.

The substance may have effects on the liver. This substance is possibly carcinogenic to humans.

A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.

With 9 natural water samples, 1 ppm quinoline had 3-10 day lag then 100% degradation in 24-48 hr; 1 ppm redose had 2-4 hr lag then 100% degradation in 24-48 hr(1). Using a 9 L aerated fermentor with 3 natural water samples and 1 sewage plant aeration effluent spiked with 10 ug/ml quinoline, an adaptation period was observed and greater than or equal to 95% biodegradation in 48 hr (25 deg C), 60 hr (25 deg C), 11 days (15 deg C) and 60 hours (25 deg C), respectively(2). Batch fermentations using low level inocula from a eutrophic pond initially spiked with 1,3,5 and 10 ug/ml quinoline resulted in 100% biodegradation in <16 hr(2). Major metabolites expected: 2-hydroxyquinoline, 2,3-dihydroxyquinoline(2). 66% theoretical BOD (TBOD) was observed after 5 days with the standard dilution method and sewage as seed(4). Using 100 ppm quinoline and 30 ppm activated sludge, < 30% TBOD was observed in 2 weeks(5). With 10 ug/ml quinoline with pond water in 9 l bottle, approximately 2 day lag period followed by 100% biodegradation in < 24 hr; four subsequent redoses in shaker flasks with 0.2% v/v (NH4)2SO4 - potassium phosphate buffer resulted in 100% biodegradation in less than or equal to 24 hours(3). Bacterium isolated from soil used quinoline as sole carbon during aerobic degradation(6). Quinoline was degraded to 2-hydroxyquinoline by soil Pseudomonads in enrichment cultures isolated from a creosote-contaminated site in Pensacola, FL(7).

At an initial concentration of 0.8 and 0.08 mg/l, quinoline had a BCF ranging from <0.1-2.5 and <1.0-3.8, respectively, in orange red killifish(1). Rainbow trout swimup fry, ranging from 0.21-0.41 g in size, were exposed to quinoline at 1 mg/l for 48 hours and analyzed for bioconcentration(2). Whole body levels of quinoline increased rapidly during the first 4 hours of exposure and reached an apparent plateau after about 24 hours. Quinoline had a calculated bioconcentration factor of 3.73. After 48 hours, the fish were placed in non-quinoline contaminated water for 24 hours and monitored for depuration(2). Less than 2% of unmetabolized quinoline remained after the 24-hour depuration period. Metabolites found within fish tissues included hydroxyquinolines and quinolinethiols(2). In a static exposure study using fathead minnows, Pimephales promelas, a bioconcentration factor (BCF) of 8 was measured(3). According to a classification scheme(4), these BCF values suggest the potential for bioconcentration in aquatic organisms is low(SRC).

The measured log Koc for quinoline is 2.84(1). The adsorption coefficients of quinoline to Ca-montmorillonite and creek sediments are 7.3 and 10.9, respectively(2). A Koc of 43 was reported using low-organic-carbon subsurface materials(11). According to a classification scheme(3), these Koc values suggest that quinoline is expected to have very high mobility in soil. Quinoline was found to be relatively mobile using a Danish sandy soil(10). Intensity of quinoline added to a natural sand aquifer on the Canadian Air Force Base Borden, Ontario, Canada via a field study using coal tar creosote were found to increase after 278 days, about 25 m from the croesote source, added at an initial concn of 10.1 g/kg creosote(4). Aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(7,8), suggesting that mobility may be much lower in some soils(SRC). The pKa of quinoline is 4.90(5), indicating that this compound will partially exist in the protonated form in the environment and cations generally adsorb to organic carbon and clay more strongly than their neutral counterparts(6); therefore, adsorption increases with increasing soil acidity(11). Sorption onto airborne particulates has been observed(9). A Kd value of 0.83 was measured using a Danish sandy soil from Lundgaard, Jutland, characterized by 2.47% organic carbon content, 80.2% sand, 13.2% silt, 4.8% clay, and a pH of 5.8(10).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN2656 (For reference only, please check.)

IMDG: UN2656 (For reference only, please check.)

IATA: UN2656 (For reference only, please check.)

ADR/RID: QUINOLINE (For reference only, please check.)

IMDG: QUINOLINE (For reference only, please check.)

IATA: QUINOLINE (For reference only, please check.)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

ADR/RID: III (For reference only, please check.)

IMDG: III (For reference only, please check.)

IATA: III (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

no data available

no data available

Health effects of exposure to the substance have not been investigated adequately.Depending on the degree of exposure, periodic medical examination is suggested.