Methyloxirane SDS

Flammable liquids, Category 1

Acute toxicity - Category 4, Oral

Acute toxicity - Category 3, Dermal

Eye irritation, Category 2

Acute toxicity - Category 3, Inhalation

Specific target organ toxicity – single exposure, Category 3

Germ cell mutagenicity, Category 1B

Carcinogenicity, Category 1B

H224 Extremely flammable liquid and vapour

H302 Harmful if swallowed

H311 Toxic in contact with skin

H319 Causes serious eye irritation

H331 Toxic if inhaled

H335 May cause respiratory irritation

H340 May cause genetic defects

H350 May cause cancer

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P233 Keep container tightly closed.

P240 Ground and bond container and receiving equipment.

P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

P242 Use non-sparking tools.

P243 Take action to prevent static discharges.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P203 Obtain, read and follow all safety instructions before use.

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower].

P370+P378 In case of fire: Use ... to extinguish.

P301+P317 IF SWALLOWED: Get medical help.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P316 Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P319 Get medical help if you feel unwell.

P318 IF exposed or concerned, get medical advice.

P403+P235 Store in a well-ventilated place. Keep cool.

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Seek medical attention if you feel unwell.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer for medical attention if breathing difficulties and/or fever develop.

This material is moderately toxic by inhalation and ingestion. It may cause irreversible and reversible changes. Skin contact with the material or solutions of the material cause irritation; diluted solutions are more irritating than undiluted materials. Exposure may cause mild depression of the central nervous system and eye, nasal, and lung irritation. Contact with the liquid can cause blindness and death. Pulmonary edema may recur up to 2 weeks after exposure. (EPA, 1998)

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Provide a low-stimulus environment. Monitor for shock and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Treat frostbite by rapid rewarming . Ethers and related compounds

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as a fog. Solid streams of water may be ineffective. Cool all effective containers with flooding quantities of water. Apply water from as far away as possible. Use "alcohol" foam, dry chemical or carbon dioxide.

Vapor is heavier than air and may travel considerable distance to source of ignition and flash back. Vapors form explosive mixture with air. If polymerization takes place in container, there may be a violent rupture of container. Explosion hazard is severe when exposed to flame. Violently reacts with acetylide- forming metals such as copper or copper alloys, ammonium hydroxide; chlorosulfonic acid; hydrochloric acid; hydrofluoric acid; nitric acid; oleum and sulfuric acid. Hazardous polymerization may occur. Avoid active catalytic surfaces such as anhydrous chlorides of iron, tin, and aluminum; peroxides of iron and aluminum; and alkali metal hydroxides, high temperatures; alkalies; aqueous acids; amines and acidic alcohols. (EPA, 1998)

Use alcohol-resistant foam, foam, water spray. In case of fire: keep drums, etc., cool by spraying with water.

Evacuate danger area! Consult an expert! Remove all ignition sources. Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking liquid in sealable dry containers. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.

Evacuate danger area! Consult an expert! Remove all ignition sources. Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking liquid in sealable dry containers. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.

Evacuation: If material leaking (not on fire) consider evacuation from downwind area based on amount of material spilled, location and weather conditions.

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding). Do NOT use compressed air for filling, discharging, or handling. Use non-sparking handtools. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Fireproof. Separated from acids, bases and strong oxidants. Dry. Cool. Well closed. Keep in the dark.Use glass or metal containers sealed with nitrogen.

TLV: 2 ppm as TWA; (SEN); A3 (confirmed animal carcinogen with unknown relevance to humans).EU-OEL: 2.4 mg/m3, 1 ppm as TWA.MAK: 4.8 mg/m3, 2 ppm; peak limitation category: I(2); sensitization of skin (SH); carcinogen category: 4; pregnancy risk group: C.EUL : EUL :

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear safety goggles or eye protection in combination with breathing protection.

Protective gloves. Protective clothing.

Use ventilation, local exhaust or breathing protection.

no data available

NIOSH considers propylene oxide to be a potential occupational carcinogen. /SRP: No IDLH value specified/.

The substance may violently polymerize under the influence of bases, acids and metal chlorides. This generates fire and explosion hazard. Reacts violently with chlorine, ammonia, strong oxidants and acids. This generates fire or explosion hazard.

It polymerizes exothermically.

FLAMMABLE, DANGEROUS FIRE RISKThe vapour is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated.1,3-PROPYLENE OXIDE react with oxidizing agents and strong acids (NTP, 1992). Reacts with Grignard reagents and organolithium compounds. An explosion occurred when propylene oxide was added to an epoxy resin. It was concluded that polymerization was catalyzed by an amine accelerator in the resin [Bretherick, 5th Ed., 1995]. Underwent polymerization when mixed with sodium hydroxide causing ignition and explosion of a drum of the crude product. [Combust Sci. Technol., 1983].

no data available

No acetylide-forming metals such as copper or copper alloys should be in contact with propylene oxide.

When heated to decomposition it emits acrid smoke and fumes.

no data available

no data available

no data available

no data available

Cancer Classification: Group B2 Probable Human Carcinogen

No information is available on the reproductive or developmental effects of propylene oxide in humans. A study with rats and rabbits exposed to propylene oxide by inhalation prior to and during gestation concluded that propylene oxide was harmful to the developing fetus but did not cause birth defects. In rats, some degree of fetotoxicity was observed in all exposed groups (including a significant reduction in the number of corpora lutea, implants, and live fetuses) and minor skeletal malformations in some; there was no maternal mortality. Increased resorptions per litter were observed in rabbits.

The substance is irritating to the eyes, skin and respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.

Repeated or prolonged contact with skin may cause dermatitis. This substance is possibly carcinogenic to humans.

A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C.

AEROBIC: 1,2-Propylene oxide, present at 100 mg/l, reached 95% of its theoretical BOD in 3 weeks using an activated sludge inoculum at 30 mg/l and the Japanese MITI test(1); therefore, this compound is expected to biodegrade rapidly. In another study, using the standard dilution method, a 5 day theoretical BOD of 8% was measured for propylene oxide using a filtered effluent seed from a biological sanitary waste treatment plant while a 5 day theoretical BOD of 9% was measured using an adapted seed(2).

An estimated BCF of 3 was calculated for 1,2-propylene oxide(SRC), using a log Kow of 0.03(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of 1,2-propylene oxide is estimated as 25(SRC), using a measured log Kow of 0.03(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 1,2-propylene oxide is expected to have very high mobility in soil(SRC).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN1280 (For reference only, please check.)

IMDG: UN1280 (For reference only, please check.)

IATA: UN1280 (For reference only, please check.)

ADR/RID: PROPYLENE OXIDE (For reference only, please check.)

IMDG: PROPYLENE OXIDE (For reference only, please check.)

IATA: PROPYLENE OXIDE (For reference only, please check.)

ADR/RID: 3 (For reference only, please check.)

IMDG: 3 (For reference only, please check.)

IATA: 3 (For reference only, please check.)

ADR/RID: I (For reference only, please check.)

IMDG: I (For reference only, please check.)

IATA: I (For reference only, please check.)

ADR/RID: No

IMDG: No

IATA: No

no data available

no data available

Do NOT take working clothes home.