Propane-1,2-diol SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Propane-1,2-diol
- CAS： 57-55-6
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
- Signal word No signal word
none
none
none
none
none
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Propane-1,2-diol
- Common names and synonyms: Propane-1,2-diol
- CAS number: 57-55-6
- EC number: 200-338-0
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest.
Remove contaminated clothes. Rinse skin with plenty of water or shower.
Rinse with plenty of water (remove contact lenses if easily possible).
Rinse mouth. Seek medical attention if you feel unwell.
Most important symptoms/effects, acute and delayed
Liquid may irritate eyes. (USCG, 1999)
Indication of immediate medical attention and special treatment needed, if necessary
Check the anion gap, arterial pH, renal function, and glucose level. Serum propylene glycol levels up to 1,000 mg/dL do not correlate well with clinical status. Patients have been conscious with serum levels of 760 mg/dL.
SECTION 5: Firefighting measures
Suitable extinguishing media
Water fog, alcohol foam, carbon dioxide, dry chemical.
Specific hazards arising from the chemical
This chemical is combustible. (NTP, 1992)
Special protective actions for fire-fighters
Use water spray, powder, alcohol-resistant foam, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Absorb liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Environmental precautions
Absorb liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from strong oxidants and alkalis. Dry. Well closed. Ventilation along the floor.Propylene glycol is hygroscopic and should be stored in a well-closed container, protected from light, in a cool, dry place.
SECTION 8: Exposure controls/personal protection
Control parameters
| Component | Propane-1,2-diol | |||
|---|---|---|---|---|
| CAS No. | 57-55-6 | |||
| Limit value - Eight hours | Limit value - Short term | |||
| ppm | mg/m3 | ppm | mg/m3 | |
| Australia | 150 | 474 | ? | ? |
| Canada - Ontario | 50 | 155 | ? | ? |
| Ireland | 150 | 470 | ? | ? |
| New Zealand | 150 (1) | 474 | ? | ? |
| ? | ? | 10 (1) | ? | ? |
| United Kingdom | 150 | 474 | ? | ? |
| Remarks | ||||
| New Zealand | (1) particulates only | |||
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety spectacles.
Protective gloves.
Avoid inhalation of mist and vapour. Use ventilation.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Liquid. Strongly hygroscopic.
-
Colour：
Colourless.
-
Odour：
Practically odorless
-
Melting point/freezing point：
< -20 °C. Atm. press.:Ca. 101.325 Pa.
-
Boiling point or initial boiling point and boiling range：
184 °C. Atm. press.:100.32 kPa.
-
Flammability：
Combustible.
-
Lower and upper explosion limit/flammability limit：
Lower flammable limit: 2.6% by volume; Upper flammable limit: 12.5% by volume
-
Flash point：
104 °C. Atm. press.:100.01 kPa.
-
Auto-ignition temperature：
> 400 °C. Atm. press.:> 100.01 - < 101.44 kPa.
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
dynamic viscosity (in mPa s) = 43.428. Temperature:25°C.;dynamic viscosity (in mPa s) = 24.247. Temperature:35°C.;dynamic viscosity (in mPa s) = 12.78. Temperature:45°C.
-
Solubility：
greater than or equal to 100 mg/mL at 70° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
Pow = 0.085. Temperature:20.5 °C.;log Pow = -1.07. Temperature:20.5 °C.
-
Vapour pressure：
20 Pa. Temperature:25 °C.
-
Density and/or relative density：
1.03. Temperature:20 °C.
-
Relative vapour density：
2.62 (vs air)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Reacts violently with strong oxidants and alkalis. This generates fire hazard.
Chemical stability
At cool temperatures, propylene glycol is stable in a well-closed container, but at high temperatures, in the open, it tends to oxidize, giving rise to products such as propionaldehyde, lactic acid, pyruvic acid, and acetic acid. Propylene glycol is chemically stable when mixed with ethanol (95%), glycerin, or water; aqueous solutions may be sterilized by autoclaving.
Possibility of hazardous reactions
Combustible liquid when exposed to heat or flame ...PROPYLENE GLYCOL is hygroscopic. It is sensitive to excessive heat (tends to oxidize at high temperatures). This compound can react with oxidizing materials. It is incompatible with acid chlorides, acid anhydrides, chloroformates, and reducing agents. It dissolves many essential oils. A mixture of this compound with hydrofluoric acid and silver nitrate was put in a glass bottle which burst 30 minutes later. (NTP, 1992)
Conditions to avoid
no data available
Incompatible materials
Reacts with strong oxidants, causing fire hazard.
Hazardous decomposition products
When heated to decomposition it emits acrid smoke and irritating fumes.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male/female) - 22 000 mg/kg bw. Remarks:This value corresponds to 21.0 ml/kg bw, with standard errors of 19.2-23.9 ml/kg bw.
- Inhalation: LC50 - rabbit - > 317 042 mg/m3 air.
- Dermal: LD50 - rabbit - > 2 000 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is mildly irritating to the eyes and respiratory tract. Ingestion of large amounts could cause metabolic acidosis.
STOT-repeated exposure
no data available
Aspiration hazard
No indication can be given whether a harmful concentration in the air will be reached.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50 - Oncorhynchus mykiss (previous name: Salmo gairdneri) - 40 613 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: LC50 - Ceriodaphnia dubia - 18 340 mg/L - 48 h.
- Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - 24 200 mg/L - 72 h.
- Toxicity to microorganisms: NOEC - Pseudomonas putida - > 20 000 mg/L - 18 h.
Persistence and degradability
AEROBIC: Propylene glycol achieved 64% of its theoretical BOD using a sewage inoculum and a 5 day incubation period(1). A Warburg respirometer study employing a sewage seed showed that propylene glycol reached 78% of its theoretical BOD during a 40 day incubation period(2). Propylene glycol achieved 2.2, 56.7 and 80% of its theoretical BOD using a sewage inoculum and 5, 10, and 50 day incubation periods, respectively(3). Using raw wastewater and synthetic seawater as inoculum, propylene glycol achieved 55 and 83% of its theoretical BOD during 5 and 20 day incubation periods, respectively(4). Using wastewater from pretreated domestic sewage, propylene glycol reached 74.5% of its theoretical BOD in 5 days(5). Propylene glycol underwent 73-78% mineralization within 51 days when incubated with various agricultural soils from Clemson University, SC under laboratory conditions at 22 deg C and 1,000 ppm propylene glycol in the soil; 40-79% mineralization was observed for propylene glycol incubated in the same soils for 64 days at 7 deg C(6).
Bioaccumulative potential
An estimated BCF of 3 was calculated for propylene glycol(SRC), using a log Kow of -0.92(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
The Koc of propylene glycol is estimated as 1(SRC), using a log Kow of -0.92(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that propylene glycol is expected to have very high mobility in soil(SRC).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Packing group, if applicable
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/