Propylamine SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Propylamine
- CAS： 107-10-8
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Flammable liquids, Category 2
Corrosive to metals, Category 1
Acute toxicity - Category 4, Oral
Acute toxicity - Category 3, Dermal
Skin corrosion, Sub-category 1B
Serious eye damage, Category 1
Acute toxicity - Category 3, Inhalation
Specific target organ toxicity – single exposure, Category 3
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H225 Highly flammable liquid and vapour
H290 May be corrosive to metals
H302 Harmful if swallowed
H311 Toxic in contact with skin
H314 Causes severe skin burns and eye damage
H331 Toxic if inhaled
H335 May cause respiratory irritation
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.
P242 Use non-sparking tools.
P243 Take action to prevent static discharges.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P234 Keep only in original packaging.
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower].
P370+P378 In case of fire: Use ... to extinguish.
P390 Absorb spillage to prevent material damage.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P317 Get medical help.
P319 Get medical help if you feel unwell.
P403+P235 Store in a well-ventilated place. Keep cool.
P406 Store in a corrosion resistant/...container with a resistant inner liner.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Propylamine
- Common names and synonyms: Propylamine
- CAS number: 107-10-8
- EC number: 203-462-3
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Half-upright position. Refer immediately for medical attention.
First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer immediately for medical attention.
Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.
Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention.
Most important symptoms/effects, acute and delayed
INHALATION: Mucous membrane and respiratory tract irritation. Tracheitis, bronchitis, pneumonitis, and pulmonary edema. EYES: Severe corneal damage or complete eye destruction. SKIN: Single drop-deep necrosis. INGESTION: Corrosive to G.I. tract. (USCG, 1999)
Indication of immediate medical attention and special treatment needed, if necessary
Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Monitor for shock and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 mg/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal . Cover skin burns with dry sterile dressings after decontamination . /Organic bases/Amines and related compounds/
SECTION 5: Firefighting measures
Suitable extinguishing media
Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool. Solid streams of water may be ineffective and spread material.
Specific hazards arising from the chemical
Special Hazards of Combustion Products: Extreme danger, enter with great care. Thermal decomposition may produce nitrogen oxides, CO and/or CO 2 . Behavior in Fire: Keep away from heat and open flame; can react vigorously. (USCG, 1999)
Special protective actions for fire-fighters
Use powder, alcohol-resistant foam, water in large amounts, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Remove all ignition sources. Evacuate danger area! Consult an expert! Personal protection: gas-tight chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Environmental precautions
Remove all ignition sources. Evacuate danger area! Consult an expert! Personal protection: gas-tight chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Overspread/spill with/ sufficient sodium bisulfate and sprinkle /with/ water. Ethylamine
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Provision to contain effluent from fire extinguishing. Fireproof. Separated from strong oxidants, strong acids and food and feedstuffs. Dry. Well closed. Store in an area without drain or sewer access.Outside or detached storage is prefered. Avoid oxidizing material, acids, and sources of halogen. Store in a cool, dry, well-ventilated location.
SECTION 8: Exposure controls/personal protection
Control parameters
| Component | Propylamine | |||
|---|---|---|---|---|
| CAS No. | 107-10-8 | |||
| Limit value - Eight hours | Limit value - Short term | |||
| ppm | mg/m3 | ppm | mg/m3 | |
| Finland | ? | ? | 5 (1) | 12 (1) |
| Latvia | ? | 5 | ? | ? |
| Remarks | ||||
| Finland | (1) 15 minutes average value | |||
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation, local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Propylamine is a clear colorless liquid with an ammonia-like odor. Flash point -35°F. Less dense than water and soluble in water. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Used in chemical analysis and to make other chemicals.
-
Colour：
Colorless liquid
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Odour：
Strong ammonia odor
-
Melting point/freezing point：
-83°C(lit.)
-
Boiling point or initial boiling point and boiling range：
48°C
-
Flammability：
Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire.
-
Lower and upper explosion limit/flammability limit：
Lower flammable limit: 2% by volume; Upper flammable limit: 10.4% by volume
-
Flash point：
-30°C(lit.)
-
Auto-ignition temperature：
604° F (USCG, 1999)
-
Decomposition temperature：
no data available
-
pH：
Alkaline
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Kinematic viscosity：
no data available
-
Solubility：
Very soluble in ethanol, acetone; soluble in benzene, chloroform; slightly soluble in carbon tetrachloride
-
Partition coefficient n-octanol/water：
log Kow = 0.48
-
Vapour pressure：
4.79 psi ( 20 °C)
-
Density and/or relative density：
0.719
-
Relative vapour density：
2 (vs air)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on burning. This produces toxic fumes including nitrogen oxides. The solution in water is a medium strong base. Reacts violently with strong acids, many compounds such as halogenated hydrocarbons, alcohols and nitroparaffins. Reacts violently with oxidants and mercury. This generates fire and explosion hazard. Attacks metals such as aluminium, copper, tin and zinc.
Chemical stability
no data available
Possibility of hazardous reactions
FLAMMABLE LIQUID.The vapour is heavier than air and may travel along the ground; distant ignition possible.Colorless, alkaline liquid, very volatile (b. p. 48° C), moderately toxic, highly flammable. Dangerous fire hazard when exposed to heat, flame, sparks, or strong oxidizers. When heated to decomposition it emits toxic fumes of oxides of nitrogen. Incompatible with triethylaluminum, complex may explode on sublimation [Chini, P. et al., Chim. e Ind (Milan), 1962, 44, p. 1220].
Conditions to avoid
no data available
Incompatible materials
Violent reaction with oxidizers and mercury, strong acids, organic anhydrides, isocyanates, aldehydes, nitroparrafins, halogenated hydrocarbons, alcohols and many other compounds. Attacks many metals and alloys, especially copper. Aqueous solutions may attack glass.
Hazardous decomposition products
When heated to decomposition it emits toxic fumes of nitroxides.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 570 mg/kg
- Inhalation: LC50 Rat inhalation 2310 ppm/4 hr
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. Exposure could cause severe swelling of the throat.
STOT-repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the respiratory tract and lungs. This may result in chronic inflammation and impaired functions.
Aspiration hazard
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50 Pimephales promelas (Fathead minnow, age 31 days, mean length 22.5 mm, mean weight 0.162 g) 308 mg/L/96 hr (95% confidence interval: 296-320 mg/L); flow through, 26.2 deg C, pH 7.73, dissolved oxygen 6.9 mg/L, hardness 48.5 mg/L CaCO3, alkalinity 49.5 mg/L CaCO3 /98% purity
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea, Lake Langedam strain, age <24 hr); Conditions: freshwater, static, 20 deg C, pH 7.8-8.0, hardness 250 mg/L CaCO3, dissolved oxygen 94-99%; Concentration: 100 mg/L for 24 hr; Effect: intoxication, immobilization
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: Propylamine was readily bio-oxidized in Warburg respirometer studies using aniline-acclimated activated sludge(1). Using a non-activated sludge inoculum, 102% of the theoretical BOD was measured over a 13 day time period(2). Propylamine was readily acclimated to and metabolized by an activated sludge(3).
Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for propylamine(SRC), using a log Kow of 0.48(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
The Koc of propylamine is estimated as 43(SRC), using a log Kow of 0.48(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that propylamine is expected to have very high mobility in soil. The pKa of propylamine is 10.71(4), indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN1277 (For reference only, please check.)
IMDG: UN1277 (For reference only, please check.)
IATA: UN1277 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: PROPYLAMINE (For reference only, please check.)
IMDG: PROPYLAMINE (For reference only, please check.)
IATA: PROPYLAMINE (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 3 (For reference only, please check.)
IMDG: 3 (For reference only, please check.)
IATA: 3 (For reference only, please check.)
Packing group, if applicable
ADR/RID: II (For reference only, please check.)
IMDG: II (For reference only, please check.)
IATA: II (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Do NOT take working clothes home.The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.