Pentachlorophenol SDS

Acute toxicity - Category 3, Oral

Acute toxicity - Category 3, Dermal

Skin irritation, Category 2

Eye irritation, Category 2

Acute toxicity - Category 2, Inhalation

Specific target organ toxicity – single exposure, Category 3

Carcinogenicity, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

H301 Toxic if swallowed

H311 Toxic in contact with skin

H315 Causes skin irritation

H319 Causes serious eye irritation

H330 Fatal if inhaled

H335 May cause respiratory irritation

H351 Suspected of causing cancer

H410 Very toxic to aquatic life with long lasting effects

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P284 [In case of inadequate ventilation] wear respiratory protection.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P203 Obtain, read and follow all safety instructions before use.

P273 Avoid release to the environment.

P301+P316 IF SWALLOWED: Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P316 Get emergency medical help immediately.

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P332+P317 If skin irritation occurs: Get medical help.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P320 Specific treatment is urgent (see ... on this label).

P319 Get medical help if you feel unwell.

P318 IF exposed or concerned, get medical advice.

P391 Collect spillage.

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . Wear protective gloves when administering first aid.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give a slurry of activated charcoal in water to drink. Give one or two glasses of water to drink. Refer for medical attention .

Dust or vapor irritates skin and mucous membranes, causing coughing and sneezing. Ingestion causes loss of appetite, respiratory difficulties, anesthesia, sweating, coma. Overexposure can cause death. (USCG, 1999)

Supportive treatment and hyperthermia control. There is no specific antidote to the poisoning; therefore treatment is supportive in nature including oxygen, fluid replacement, and most importantly, fever control. Reduce elevated body temperature by physical means. Administer sponge baths and use fans to increase evaporation. In fully conscious patients, administer cold, sugar-containing liquids by mouth as tolerated. Cooling blankets and ice packs to body surfaces may also be used. Antipyretic therapy with salicylates is strongly contraindicated as salicylates also uncouple oxidative phosphorylation. Other antipyretics are thought to be of no use because of the peripherally mediated mechanism of hyperthermia in poisoning of this nature. Neither the safety nor the effectiveness of the other antipyretics has been tested. Administer oxygen continuously by mask to minimize tissue anoxia. Unless there are manifestations of cerebral or pulmonary edema or of inadequate renal function, administer intravenous fluids to restore hydration and support physiologic mechanisms for heat loss and toxicant disposition. Monitor serum electrolytes, adjusting IV infusions to stabilize electrolyte concentrations. Follow urine contents of albumin and cells, and keep an accurate hourly record of intake/output to forestall fluid overload if renal function declines. Caution: In the presence of cerebral edema and/or impaired renal function, intravenous fluids must be administered very cautiously to avoid increased intracranial pressure and pulmonary edema. Central monitoring of venous and pulmonary wedge pressures may be indicated. Such critically ill patients should be treated in an intensive care unit.

If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn or burns with difficulty.

Special Hazards of Combustion Products: Generates toxic and irritating vapors. (USCG, 1999)

In case of fire in the surroundings, use appropriate extinguishing media.

Personal protection: chemical protection suit and filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: chemical protection suit and filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Shovel into suitable dry container.

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Provision to contain effluent from fire extinguishing. Separated from strong oxidants and food and feedstuffs. Keep in a well-ventilated room.Where possible, automatically transfer material from drums or other storage containers to process containers. Sources of ignition such as smoking and open flames are prohibited where this chemical is handled, used, or stored. Metal containers involving the transfer of this chemical should be grounded and bonded. A regulated, marked area should be established where this chemical is handled, used or stored ...

TLV: 0.5 mg/m3, as TWA; 1 mg/m3 as STEL; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued.MAK: skin absorption (H); carcinogen category: 2

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear safety goggles, face shield or eye protection in combination with breathing protection.

Protective gloves. Protective clothing.

Use local exhaust or breathing protection.

no data available

Decomposes above 200°C . This produces toxic and corrosive fumes including dioxins. Reacts violently with strong oxidants.

Decomposes on heating. This produces toxic and corrosive fumes including hydrogen chloride and dioxins. Reacts with strong oxidants. This generates fire and explosion hazard.

Stable; prolonged heating above 200 deg C produces traces of octachlorodibenzo-para-dioxin.

Not combustible but if involved in a fire decomposes to produce hydrogen chloride and other irritants and toxic gases. May be in hydrocarbon solution.PENTACHLOROPHENOL may react with strong oxidizing agents. Incompatible with strong bases, acid chlorides and acid anhydrides. Forms salts with alkaline metals. Solutions in oil cause natural rubber to deteriorate, but synthetic rubber may be used in equipment and for protective clothing (NTP, 1992).

no data available

Contact with strong oxidizers may cause fires or explosions.

Hydrogen chloride, chlorinated phenols, and carbon monoxide may be released upon decomposition.

no data available

no data available

no data available

no data available

Evaluation: There is limited evidence in humans for the carcinogenicity of combined exposures to polychlorophenols and their sodium salts. ... There is sufficient evidence in experimental animals for the carcinogenicity of pentachlorophenol. Overall evaluation: Combined exposures to polychlorophenols or to their sodium salts are possibly carcinogenic to humans (Group 2B). Polychlorophenols & sodium salts

One study reported that 22 out of 90 women with histories of spontaneous abortions, unexplained infertility, or menstrual disorders were found to have elevated blood levels of pentachlorophenol and/or lindane. However, a direct causal relationship with pentachlorophenol exposure cannot be inferred from this study due to the presence of lindane in the blood and other possible confounding factors. Oral animal studies suggest that exposure to pentachlorophenol decreases the survival of the offspring in rats. Other oral animal studies have found evidence that pentachlorophenol produces maternal toxicity (depressed maternal body weight), but does not cause birth defects.

The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the cardiovascular system. This may result in cardiac disorders and heart failure.

The substance may have effects on the central nervous system, kidneys, liver, lungs, immune system and thyroid. This substance is possibly carcinogenic to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.

Screening biodegradability tests give conflicting results(1-7); pentachlorophenol does biodegrade but may require several weeks for acclimation(3-7). Using an acclimated pentachlorophenol-degrading culture, half-lives of 85 (lag time of 27 hours) and 420 (lag time of 220 hours) hours were reported for aerobic and anaerobic conditions, respectively(8). Pentachlorophenol, present at 100 mg/L, reached 1% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(9). Acclimation of microbial communities to pentachlorophenol appears to increase tolerance to pentachlorophenol and/or select for pentachlorophenol-tolerant microorganisms(10). Pentachlorophenol, at an initial concn of 300-500 ug/L, had a half-life of 2.6 days using a sludge inoculum(11). At this concentration, no lag phase was seen(11).

BCF values of 776 in fathead minnow(1), 251-5370 in rainbow trout(2,3), 5-50 in sheepshead minnows(4), 295 in mosquito fish(5); 708(6), 960(7), and 977(8) in zebra fish, and 417 in golden orfe(6) have been reported. The accumulation increased with temperature in golden orfe and decreased with temperature in zebra fish(6). BCF values of 39-198 and 45-224 were measured in an 8-week carp study with pentachlorophenol concns of 30 and 3 ug/L, respectively(9). BCF values of 214 in Jordanella floridae and 380-1698 in Oryzias latipes were reported for pentachlorophenol(8). A BCF value of 13 was measured in bluegill muscle in an 8-day study(10). According to a classification scheme(11), these BCF values suggest that bioconcentration in aquatic organisms is low to very high(SRC), with the value being greatly influenced by environmental pH(12).

Koc values for pentachlorophenol of 2285 (pH 4.9), 4267 (pH 5.0), 6224 (pH 5.9), 3684 (pH 4.6), 121681 (pH 3.5), 121810 (pH 3.9), 97471 (pH 3.7), 1586 (pH 5.0), 4109 (pH 5.1), 4009 (pH 5.5), 123563 (pH 3.5) have been reported(1). According to a classification scheme(2), these Koc values indicate that pentachlorophenol is expected to have slight to no mobility in soil(SRC). Freundlich isotherm coefficients were determined to be 5 (silty sand soil), 5 (aquifer), and 3 (marine sediment)(9). A log Koc of 3.16 was observed in sediment of the Yangtse River in China(10). Since pentachlorophenol has a pKa of 4.70(3), its adsorptivity will be strongly dependent on pH. The Freundlich adsorption constant for 6 Dutch soils are (soil (% organic carbon, pH) log KF, 1/N): humic sand (1.7%, 3.4) 2.2, 0.9; humic sand (2.2%, 4.9) 2.2, 0.9; humic-rich sand (3.2%, 4.7) 2.6, 1.0; peat (29.8%, 4.6) 3.3, 0.8; light loam (0.9%, 7.5) 1.1, 0.9; heavy loam (1.7%, 7.1) 1.5, 0.8(4). For loam soil where pH >pKa, significant contribution from the phenolate ion can be expected. The Koc values for the total dissociated phenol was calculated to be 1250 and 1800 for light and heavy loam, respectively, while for the undissociated species, the Koc is 25,000(5). The fraction of pentachlorophenol which is sorbed decreases linearly with pH to a pH 6; above pH 6, significant adsorption of the anion again occurs, contributing as much as 20% of the total adsorption effect at pH 8(4). K values for a Bjuv clay (organic carbon 12%) and an aquifer soil (organic carbon 0.02%) were 433 and 86 at pH 3.0, respectively, and 167 and 50 at pH 6.5, respectively(4). K values for a bentonite clay of 72 and 34 were measured at pH 3.0 and 6.5, respectively(4). The nonionized form of pentachlorophenol had a K value of 3.63 mL/g in a sandy aquifer material (organic C 0.13%) (Koc 2792)(6). K values measured at pH 7 for a Guishan sandy loam (organic carbon 1.4%) and a Shulin clay loam (organic carbon 2.0%) were 2.56 (Koc 183) and 7.03 (Koc 352), respectively(7). The Koc for pentachlorophenol was measured for five soils (foc from 0.07 to 2.96%; 3 sands, 1 loamy sand, 1 loam)(8). At pH 4, 7, and 10, the Koc values ranged from 10091-40120 (avg 19675), 178-1956 (avg 651), and 126-942 (avg 501), respectively(8).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN2761 (For reference only, please check.)

IMDG: UN2761 (For reference only, please check.)

IATA: UN2761 (For reference only, please check.)

ADR/RID: ORGANOCHLORINE PESTICIDE, SOLID, TOXIC (For reference only, please check.)

IMDG: ORGANOCHLORINE PESTICIDE, SOLID, TOXIC (For reference only, please check.)

IATA: ORGANOCHLORINE PESTICIDE, SOLID, TOXIC (For reference only, please check.)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

ADR/RID: I (For reference only, please check.)

IMDG: I (For reference only, please check.)

IATA: I (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

no data available

no data available

The commercial product may contain very toxic impurities (dioxins).The odour warning when the exposure limit value is exceeded is insufficient.