Phosgene SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Phosgene
- CAS： 75-44-5
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Gases under pressure: Liquefied gas
Skin corrosion, Sub-category 1B
Acute toxicity - Category 2, Inhalation
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H314 Causes severe skin burns and eye damage
H330 Fatal if inhaled
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P271 Use only outdoors or in a well-ventilated area.
P284 [In case of inadequate ventilation] wear respiratory protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316 Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P320 Specific treatment is urgent (see ... on this label).
P410+P403 Protect from sunlight. Store in a well-ventilated place.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Phosgene
- Common names and synonyms: Phosgene
- CAS number: 75-44-5
- EC number: 200-870-3
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Half-upright position. Administration of oxygen may be needed. Refer immediately for medical attention.
ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention.
Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms/effects, acute and delayed
Phosgene is a lung toxicant that causes damage to the capillaries, bronchioles and alveoli of the lungs, by decomposition to hydrochloric acid. There is little immediate irritant effect upon the respiratory tract, and the warning properties of the gas are therefore very slight. Pulmonary edema, bronchopneumonia and occasionally lung abscesses develop. Degenerative changes in the nerves have been reported as later developments. A concentration of 25 ppm is dangerous for exposures lasting 30-60 minutes and 50 ppm is rapidly fatal after even short exposure. (EPA, 1998)
Indication of immediate medical attention and special treatment needed, if necessary
PREHOSPITAL/ Quickly access for a patent airway, ensure adequate respiration and pulse. If trauma is suspected, maintain cervical immobilization manually and apply a cervical collar and a backboard when feasible. ... If victims can walk, lead them out of the Hot Zone to the Decontamination Zone. Victims who are unable to walk may be removed on backboards or gurneys; if these are not available, carefully carry or drag victims to safety. Victims should be kept warm and quiet; any activity subsequent to exposure may increase the likelihood of death.
SECTION 5: Firefighting measures
Suitable extinguishing media
Use remote equipment wherever possible. Use water spray to keep fire-exposed containers cool. Extinguish fire using agent suitable for surrounding fire.
Specific hazards arising from the chemical
When heated to decomposition or on contact with water or steam, it will react to produce toxic and corrosive fumes. Reacts violently with aluminum; tert-butyl azido formate; 2,4-hexadiyn-1,6-diol; isopropyl alcohol; potassium; sodium; hexafluoro isopropylidene; amino lithium; lithium. Stable in steel containers if dry. Avoid moisture. (EPA, 1998)
Special protective actions for fire-fighters
In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep cylinder cool by spraying with water. NO direct contact with water. Combat fire from a sheltered position.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Ventilation. Shut off cylinder if possible. Remove gas with fine water spray. Isolate the area until the gas has dispersed.
Environmental precautions
Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Ventilation. Shut off cylinder if possible. Remove gas with fine water spray. Isolate the area until the gas has dispersed.
Methods and materials for containment and cleaning up
For liquid spills, cover with sodium bicarbonate or an equal mixture of soda ash and slaked lime. After mixing, spray water from an atomizer with great precaution. Transfer slowly into a large container of water. ... For gas spills, allow gas to flow into a mixed solution of caustic soda and slaked lime. If possible, keep in a hood until cylinder is emptied.
SECTION 7: Handling and storage
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Fireproof if in building. Isolated from work area. Separated from incompatible materials. See Chemical Dangers. Cool. Dry. Ventilation along the floor.Phosgene must be stored to avoid contact with water, moisture, or steam since violent reactions occur. Store in tightly closed, steel containers in an isolated area away from the work area and separated form all other materials, as well as sunlight. Although phosgene in anhydrous equipment is not corrosive to ordinary metals, in presence of moisture, use monel, tantalum, or glass-lined storage containers. Phosgene should be stored away from heating and cooling ducts. Containers should be frequently inspected for leaks.
SECTION 8: Exposure controls/personal protection
Control parameters
TLV: 0.1 ppm as TWA.MAK: 0.41 mg/m3, 0.1 ppm; peak limitation category: I(2); pregnancy risk group: C.EU-OEL: 0.08 mg/m3, 0.02 ppm as TWA; 0.4 mg/m3, 0.1 ppm as STEL
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear face shield or eye protection in combination with breathing protection.
Cold-insulating gloves. Protective clothing.
Use closed system or ventilation.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Phosgene is a colorless gas or very low-boiling, volatile liquid (b.p. 8.3°C, 48°F) with an odor of new-mown hay or green corn. Extremely toxic. Warning properties of the gas inhaled are slight, death may occur within 36 hours (Lewis, 3rd ed., 1993, p. 1027). Prolonged exposure of the containers to intense heat may result in their violent rupturing and rocketing. Rate of onset: Immediate & Delayed (Lungs) Persistence: Minutes - hours Odor threshold: 0.5 ppm Source/use/other hazard: Dye, pesticide, and other industries; history as war gas, corrosive/irritating .
-
Colour：
Colorless gas [Note: A fuming liquid below 47 degrees F. Shipped as a liquefied compressed gas].
-
Odour：
Suffocating odor; when diluted with air there is an odor reminiscent of moldy hay
-
Melting point/freezing point：
-118°C
-
Boiling point or initial boiling point and boiling range：
8.2°C at 760 mmHg
-
Flammability：
Not combustible.
-
Lower and upper explosion limit/flammability limit：
no data available
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Flash point：
4°C
-
Auto-ignition temperature：
Not flammable (USCG, 1999)
-
Decomposition temperature：
no data available
-
pH：
no data available
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Kinematic viscosity：
6.8488X10-4 Pa.s at 263.15 K
-
Solubility：
Very slightly soluble (NTP, 1992)
-
Partition coefficient n-octanol/water：
no data available
-
Vapour pressure：
1180 mm Hg ( 20 °C)
-
Density and/or relative density：
0.924g/mLat 25°C
-
Relative vapour density：
3.4 (EPA, 1998) (Relative to Air)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes above 300°C . Decomposes on contact with water or moisture. This produces corrosive hydrogen chloride (see ICSC 0163). Reacts violently with ethanol, strong oxidants, ammonia, amines and aluminium. Attacks many metals in the presence of water.
Phosgene (CG) reacts violently with strong oxidants, amines, alkalis, and many metals.Phosgene (CG) reacts with alcohols and ammonia.Above 572°F (300°C), phosgene (CG) decomposes in the presence of moisture to form hydrochloric acid and carbon dioxide.In the presence of moisture, phosgene (CG) attacks plastic, rubber, and many metals.
Chemical stability
no data available
Possibility of hazardous reactions
NONCOMBUSTIBLEThe gas is heavier than air.,Vapors are heavier than air. They will spread along the ground and collect and stay in poorly-ventilated, low-lying, or confined areas (e.g., sewers, basements, and tanks).Hazardous concentrations may develop quickly in enclosed, poorly-ventilated, or low-lying areas. Keep out of these areas. Stay upwind.Phosgene (CG) liquid sinks in water.PHOSGENE is water reactive. Incompatible with strong oxidizing agents, alcohols, amines, alkali. May react violently with aluminum, alkali metals (lithium, potassium, sodium), alcohols (isopropyl alcohol, 2,4-hexadiyn-1,6-diol), sodium azide [Bretherick, 5th ed., 1995, p. 134]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. Phosgene reacts with phosphate or silicate salts, yielding water-reactive and toxic POCl3 with phosphates (Dunlap, K.L. 2005. Phosgene. In Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc.).
Conditions to avoid
no data available
Incompatible materials
Violent reaction with strong oxidizers, amines, aluminum. Attacks metals in the presence of water. Attacks plastic, rubber, and coatings.
Hazardous decomposition products
When heated to decomposition ... it will react to produce toxic and corrosive fumes of /carbon monoxide/ and /hydrogen chlorides/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: no data available
- Inhalation: LC50 Rat inhalation 0.334 mg/L (10 min exposure)
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
EPA-II
Reproductive toxicity
No information is available on the reproductive or developmental effects of phosgene in humans or animals.
STOT-single exposure
Rapid evaporation of the liquid may cause frostbite. The substance is irritating to the eyes and respiratory tract. Inhalation of the gas may cause lung oedema and chemical pneumonitis. The effects may be delayed. Medical observation is indicated. See Notes. Exposure at high levels could cause death.
STOT-repeated exposure
Lungs may be affected by repeated or prolongated exposure. This may result in impaired functions and decreased resistance to infection.
Aspiration hazard
A harmful concentration of this gas in the air will be reached very quickly on loss of containment.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
no data available
Bioaccumulative potential
Phosgene is extremely volatile and hydrolyzes rapidly in water (20 seconds at 0 deg C(1)), suggesting that bioconcentration will not be an important environmental fate process(SRC).
Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of phosgene can be estimated to be 2.2(SRC). According to a classification scheme(2), this estimated Koc value suggests that phosgene is expected to have very high mobility in soil.
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN1076 (For reference only, please check.)
IMDG: UN1076 (For reference only, please check.)
IATA: UN1076 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: PHOSGENE (For reference only, please check.)
IMDG: PHOSGENE (For reference only, please check.)
IATA: PHOSGENE (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 2.3 (For reference only, please check.)
IMDG: 2.3 (For reference only, please check.)
IATA: 2.3 (For reference only, please check.)
Packing group, if applicable
ADR/RID: (For reference only, please check.)
IMDG: (For reference only, please check.)
IATA: (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
A serious intoxication may develop even without experiencing symptoms of irritation or detecting the characteristic odour (grass or hay).The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.Do NOT spray water on a leaking cylinder (to prevent corrosion of the cylinder).Turn leaking cylinder with the leak up to prevent escape of gas in liquid state.The information in this ICSC would also apply to phosgene generated by chemical reactions or by decomposition of organic compounds containing chlorine.