Dichloro(phenyl)arsine SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Dichloro(phenyl)arsine
- CAS： 696-28-6
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
no data available
GHS label elements, including precautionary statements
- Signal word no data available
no data available
no data available
no data available
no data available
no data available
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Dichloro(phenyl)arsine
- Common names and synonyms: Dichloro(phenyl)arsine
- CAS number: 696-28-6
- EC number: 211-791-9
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms/effects, acute and delayed
Median lethal dosage 2600 mg-minute/m3. Mean incapacitating dosage 16 mg-minute/m3 as a vomiting agent and 1800 mg-minute/m3 as a blistering agent. 633 mg-minute/m3 produces eye injury. Poisonous; may be fatal if inhaled, swallowed, or absorbed through skin. Contact may cause burns to skin and eyes. Strong irritant to eyes, skin, and issue. (EPA, 1998)
Indication of immediate medical attention and special treatment needed, if necessary
The purpose of the study was to identify binding sites of organic arsenic in the erythrocyte and to explain species differences in binding. Washed erythrocytes were exposed to graded concentrations of (14)C-phenyldichloroarsine (PDA) in phosphate-buffered saline containing 0.1% glucose and 0.1% bovine serum albumin. At low phenyldichloroarsine concentrations, all cells bind the arsenical rapidly (within 10 min) and quantitatively. Human, pig, hamster, guinea pig, and mouse erythrocytes approached saturation at 0.02-0.3 mumol phenyldichloroarsine/10(9) cells, depending on the species. Saturation points correlated well with each respective species erythrocyte glutathione content. In contrast, rat erythrocytes showed no sign of saturation at phenyldichloroarsine loads as high as 3.0 mumol/10(9) cells. Hemolysates of phenyldichloroarsine-treated erythrocytes were subjected to Sephadex G-75 gel filtration chromatography. (14)C from rat hemolysate was distributed between the hemoglobin and small molecular weight (glutathione-containing) fractions. In all other species, the (14)C eluted almost exclusively with the glutathione-containing fractions. In equilibrium dialysis experiments, human hemoglobin did not bind phenyldichloroarsine, whereas rat hemoglobin bound 2 phenyldichloroarsine/mol with Kd approximately 5 m. In conclusion, glutathione is the principle binding site of phenyldichloroarsine in erythrocytes. In most species,the arsenical does not bind to hemoglobin, even though it has free (titratable) sulfhydryls considerably in excess of the glutathione concentration. In rat erythrocytes, phenyldichloroarsine binds both to glutathione and to hemoglobin.
SECTION 5: Firefighting measures
Suitable extinguishing media
Wear positive pressure breathing apparatus. Move container from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material. Extinguish with dry chemical, carbon dioxide, water spray, foam, or fog. (EPA, 1998)
Specific hazards arising from the chemical
This material may burn but does not ignite readily. Containers may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases. Upon decomposition hydrogen chloride and phenylarsenious oxide are emitted. Unstable. Decomposed by water. (EPA, 1998)
Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Decontamination of closed areas may be accomplished with bleach or bicarbonate solns. No decontamination of open areas is needed.
SECTION 7: Handling and storage
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
SECTION 8: Exposure controls/personal protection
Control parameters
no data available
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
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Physical state：
Phenyldichloroarsine is a colorless odorless liquid. Density 1.654 g / cm3. Used as a lachrymator poison gas. Toxic by inhalation and skin absorption.
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Colour：
Liquid; microcrystalline mass @ freezing point
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Odour：
no data available
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Melting point/freezing point：
-15.6°C
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Boiling point or initial boiling point and boiling range：
252~255
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Flammability：
no data available
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Lower and upper explosion limit/flammability limit：
no data available
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Flash point：
High enough not to interfere with military use (EPA, 1998)
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Auto-ignition temperature：
no data available
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Decomposition temperature：
no data available
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pH：
no data available
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Kinematic viscosity：
no data available
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Solubility：
Soluble in acetone
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Partition coefficient n-octanol/water：
no data available
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Vapour pressure：
0.033 mm Hg at 77° F (EPA, 1998)
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Density and/or relative density：
1.654
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Relative vapour density：
7.7 (EPA, 1998) (Relative to Air)
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Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
The liquid reacts with water or with moist air to form the strong acid, hydrochloric acid. Very Corrosive!
Chemical stability
Volatility 404 mg/cu m @ 20 deg c
Possibility of hazardous reactions
PHENYLDICHLOROARSINE is incompatible with acids and bases. A reducing agent, therefore generally incompatible with oxidizing agents.
Conditions to avoid
no data available
Incompatible materials
When exposed to heat, water, or steam it reacts to produce corrosive fumes of /chloride/.
Hazardous decomposition products
Decomposes /in/ water.
SECTION 11: Toxicological information
Acute toxicity
- Oral: no data available
- Inhalation: LC50 Mouse inhalation 3300 mg/cu m/10 min
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
The Human Health Assessment Group in EPA's Office of Health and Environmental Assessment has evaluated dichlorophenylarsine for carcinogenicity. According to their analysis, the weight-of-evidence for dichlorophenylarsine is group D, which is based on no data evidence in humans and no data evidence in animals. As a group D chemical, dichlorophenylarsine is considered not classifiable to human carcinogenicity. Organic arsenic compounds are considered to be chemically different from the inorganic arsenic compounds such that they are assessed for carcinogenicity separately from the inorganic arsenic compounds. There are no data (weight-of-evidence group D) implicating organic arsenic compounds so that the carcinogenicity is indeterminate of this time.
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
no data available
Bioaccumulative potential
An estimated BCF of 46 was calculated for phenyldichloroarsine(SRC), using an estimated log Kow of 3.1(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). However, phenyldichloroarsine rapidly hydrolyzes in water(4); therefore, bioconcentration may be less than estimated(SRC).
Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc for phenyldichloroarsine can be estimated to be 820(SRC). According to a classification scheme(2), this estimated Koc value suggests that phenyldichloroarsine is expected to have low mobility in soil(SRC).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: no data available
IMDG: no data available
IATA: no data available
UN Proper Shipping Name
ADR/RID: no data available
IMDG: no data available
IATA: no data available
Transport hazard class(es)
ADR/RID: no data available
IMDG: no data available
IATA: no data available
Packing group, if applicable
ADR/RID: no data available
IMDG: no data available
IATA: no data available
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/