(R)-N-((5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo[c]pyran-7-yl)carbonyl)-3-phenylalanine SDS

Acute toxicity - Category 2, Oral

Eye irritation, Category 2

Acute toxicity - Category 2, Inhalation

Carcinogenicity, Category 2

Reproductive toxicity, Category 2

H300 Fatal if swallowed

H319 Causes serious eye irritation

H330 Fatal if inhaled

H351 Suspected of causing cancer

H361 Suspected of damaging fertility or the unborn child

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P284 [In case of inadequate ventilation] wear respiratory protection.

P203 Obtain, read and follow all safety instructions before use.

P301+P316 IF SWALLOWED: Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P316 Get emergency medical help immediately.

P320 Specific treatment is urgent (see ... on this label).

P318 IF exposed or concerned, get medical advice.

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

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Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Rinse with pure water for at least 15 minutes. Consult a doctor.

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

SYMPTOMS: Symptoms of exposure to this compound may include irritation. It can also interfere with the carbohydrate metabolism of eye lenses. ACUTE/CHRONIC HAZARDS: This compound is highly toxic orally. It may be fatal by ingestion or inhalation. When heated to decomposition it emits very toxic fumes of chlorine and nitrogen oxides. (NTP, 1992)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Poisons A and B

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

Wear self-contained breathing apparatus for firefighting if necessary.

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. Chemical Carcinogens

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens

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Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

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Relatively unstable to light & air; fading and degradation upon brief exposure of chromatograms to light, especially at high humidity.

OCHRATOXIN A is incompatible with strong oxidizing agents, strong acids and strong bases. (NTP, 1992). It is a carboxylic acid derivative. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt.

no data available

The lactone group is saponified by alkalis

When heated to decomposition it emits very toxic fumes of /hydrogen chloride/ and /nitric oxides/.

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Evaluation: There is inadequate evidence in humans for the carcinogenicity of ochratoxin A. There is sufficient evidence in experimental animals for the carcinogenicity of ochratoxin A. Overall evaluation: Ochratoxin A is possibly carcinogenic to humans (Group 2B).

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AEROBIC: Ochratoxin A, present at 24.3, 25.3 and 16.0 ug/kg, was not detected after 225 days using three agricultural topsoils from Danish experimental farms: a sandy soil (Jundevad, 3.9% clay, 4.1% silt, 89.0% sand), a sandy clay soil (Askov, 10.6% clay, 11.8% silt, 74.6% sand) and a gyttja soil with a high content of silt (Lammefjorden, 4.4% clay, 12.1% silt, 80.6% sand), respectively. Degradation proceeded fast initially followed by a slower transformation step. The first-order degradation rates were 0.73, 1.56 and 2.91/day, respectively, corresponding to a half-lives of 0.2-1 days. Degradation was faster in experimental pots planted with barley. The ochratoxin A employed was produced by Penicillium verrucosum(1).

An estimated BCF of 1200 was calculated in fish for ochratoxin A(SRC), using a log Kow of 4.74(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is very high(SRC). However, it has been demonstrated that ochratoxin A is toxic in marine water-reared sea bass (Dicentrarchus labrax L.); exposure via contaminated feed(4).

The Koc of the neutral species of ochratoxin A is estimated as 3800(SRC), using a log Kow of 4.74(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that ochratoxin A is expected to have slight mobility in soil. The estimated pKa values of ochratoxin A are 2.6 and 8.2, indicating that this compound will exist almost entirely in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN3462 (For reference only, please check.)

IMDG: UN3462 (For reference only, please check.)

IATA: UN3462 (For reference only, please check.)

ADR/RID: TOXINS, EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S. (For reference only, please check.)

IMDG: TOXINS, EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S. (For reference only, please check.)

IATA: TOXINS, EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S. (For reference only, please check.)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

ADR/RID: I (For reference only, please check.)

IMDG: I (For reference only, please check.)

IATA: I (For reference only, please check.)

ADR/RID: No

IMDG: No

IATA: No

no data available

no data available