Nicotine SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Nicotine
- CAS： 54-11-5
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 1, Oral
Acute toxicity - Category 1, Dermal
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H300 Fatal if swallowed
H310 Fatal in contact with skin
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P262 Do not get in eyes, on skin, or on clothing.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P273 Avoid release to the environment.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P391 Collect spillage.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Nicotine
- Common names and synonyms: Nicotine
- CAS number: 54-11-5
- EC number: 200-193-3
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Refer for medical attention.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Give a slurry of activated charcoal in water to drink. Refer for medical attention .
Most important symptoms/effects, acute and delayed
Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)
It is classified as super toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for a 70 kg (150 lbs.) person. It may be assumed that ingestion of 40-60 mg of nicotine is lethal to humans. There is fundamental difference between acute toxicity from use of nicotine as insecticide or from ingestion, and chronic toxicity that may be caused by prolonged exposure to small doses as occurs in smoking. Maternal smoking during pregnancy is associated with increased risk of spontaneous abortion, low birth weight and still-birth. Nicotine was found as a co-carcinogen in animals. (EPA, 1998)
Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Nicotine and Related Compounds
SECTION 5: Firefighting measures
Suitable extinguishing media
To fight fire, use alcohol foam, dry chemical, carbon dioxide.
Specific hazards arising from the chemical
Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways. (ERG, 2016)
There is a moderate explosion hazard when exposed to heat or flame. When heated to decomposition, it emits nitrogen oxides, carbon monoxide and other highly toxic fumes. Avoid oxidizing materials. Stable under normal conditions. Avoid heat or flames. (EPA, 1998)
Special protective actions for fire-fighters
Use water spray, powder, alcohol-resistant foam, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
1. ventilate area of spill or leak. 2. for small quantities, absorb on paper towels. evaporate in safe place (such as fume hood). allow sufficient time for evaporating vapors to completely clear hood ductwork.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Above 95°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Provision to contain effluent from fire extinguishing. Separated from strong oxidants and food and feedstuffs. Dry. Ventilation along the floor.
SECTION 8: Exposure controls/personal protection
Control parameters
TLV: 0.5 mg/m3, as TWA; (skin).MAK: skin absorption (H).EU-OEL: 0.5 mg/m3 as TWA; (skin)
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety goggles, face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation, local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Nicotine and salts is a colorless to light yellow or brown liquid. Combustible. Toxic by inhalation and by skin absorption. Produces toxic oxides of nitrogen during combustion.
-
Colour：
Colorless to pale yellow, oily liquid
-
Odour：
Fish-like odor when warm
-
Melting point/freezing point：
-8°C
-
Boiling point or initial boiling point and boiling range：
247°C
-
Flammability：
Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
-
Lower and upper explosion limit/flammability limit：
LOWER 0.7% BY VOL; UPPER 4.0% BY VOL
-
Flash point：
101°C
-
Auto-ignition temperature：
471° F (USCG, 1999)
-
Decomposition temperature：
247°C
-
pH：
pH = 10.2 (0.05 Molar solution)
-
Kinematic viscosity：
Becomes viscous on exposure to air
-
Solubility：
Miscible (NTP, 1992)
-
Partition coefficient n-octanol/water：
1.2
-
Vapour pressure：
1 mm Hg at 143.24° F (EPA, 1998)
-
Density and/or relative density：
1.015
-
Relative vapour density：
5.61 (EPA, 1998) (Relative to Air)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on heating. This produces toxic fumes including nitrogen oxides and carbon monoxide. Reacts violently with strong oxidants.
Nicotine decomposes on heating, producing nitrogen oxides, carbon monoxide, and other highly toxic fumes.Nicotine reacts violently with strong oxidants.Nicotine is incompatible with strong acidsNicotine will attack some forms of plastics, rubber, and coatings.
Chemical stability
Nicotine is photosensitive and will gradually turn brown when exposed to light or air.
Possibility of hazardous reactions
COMBUSTIBLE WHEN EXPOSED TO HEAT OR FLAME.At 68°F (20°C) evaporation of nicotine can quickly cause hazardous air conditions in small enclosed spaces.Nicotine readily absorbs moisture from the air (hygroscopic).Nicotine is light sensitive (photosensitive) and will gradually turn brown on exposure to air or light.Nicotine-An alkaloid produced from tobacco. Colorless, oily liquid, combustible, highly toxic. When heated to decomposition it emits very toxic fumes of carbon monoxide and oxides of nitrogen [Lewis, 3rd ed., 1993, p. 919].
Conditions to avoid
no data available
Incompatible materials
Can react with oxidizing materials.
Hazardous decomposition products
When heated to decomp it emits /nitrogen oxides, carbon monoxide/ and other highly toxic fumes. ...
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 188 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is irritating to the eyes and skin. The substance may cause effects on the cardiovascular system and central nervous system. This may result in convulsions and respiratory failure. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated.
STOT-repeated exposure
Animal tests show that this substance possibly causes toxic effects upon human reproduction.
Aspiration hazard
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50; Species: Oncorhynchus mykiss (Rainbow trout, age 13-21 days fry); Conditions: freshwater, static, 12 deg C; Concentration: 4000 ug/L for 96 hr /> or =95% purity
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea, age <24 hr neonate); Conditions: freshwater, static, 21 deg C, pH 7.6; Concentration: 0.035 mmol/L for 24 hr; Effect: intoxication, immobilization
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
Bacterial strain, isolated from tobacco leaves, oxidized nicotine to gamma-aminobutyric acid ... arthrobacter oxydans, adapted to l-, d-, dl-nicotine, converted both ... isomers initially to 6-hydroxy nicotine. these ... then metabolized to ... 6-hydroxy-n-methylmyosmine.
Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for nicotine(SRC), using a log Kow of 1.17(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
The Koc of nicotine is estimated as 100(SRC), using a log Kow of 1.17(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that nicotine is expected to have high mobility in soil. The pKb1 of nicotine is 6.16(4), indicating that this compound will partially exist in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Adsorption of nicotine, under more acidic conditions, can be represented as a high-affinity type isotherm, indicating that nicotine has a high affinity for humic acids in soil as a result of protonation of the pyrrolidine nitrogen atom of nicotine(6).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN2903 (For reference only, please check.)
IMDG: UN2903 (For reference only, please check.)
IATA: UN2903 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: PESTICIDE, LIQUID, TOXIC, FLAMMABLE, N.O.S., flash point not less than 23 °C (For reference only, please check.)
IMDG: PESTICIDE, LIQUID, TOXIC, FLAMMABLE, N.O.S., flash point not less than 23 °C (For reference only, please check.)
IATA: PESTICIDE, LIQUID, TOXIC, FLAMMABLE, N.O.S., flash point not less than 23 °C (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/