Diethylnitrosoamine SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Diethylnitrosoamine
- CAS： 55-18-5
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Carcinogenicity, Category 1B
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H301 Toxic if swallowed
H350 May cause cancer
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Diethylnitrosoamine
- Common names and synonyms: Diethylnitrosoamine
- CAS number: 55-18-5
- EC number: 200-226-1
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms/effects, acute and delayed
ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of nitrogen oxides. (NTP, 1992)
Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/Amines and related compounds/
SECTION 5: Firefighting measures
Suitable extinguishing media
Use dry chemical, carbon dioxide, alcohol foam, or polymer foam extinguishers.
Specific hazards arising from the chemical
This chemical is combustible. (NTP, 1992)
Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Spills ... absorbed by celite (r) or commercial spill absorbant. after absorbant containing major share of nitrosoamine ... picked up (avoid dusts; do not sweep), surface should be thoroughly cleaned with strong detergent soln. if major spill occurs outside of ventilated area, room should be evacuated & cleanup operation should be carried out by persons equipped with self-contained respirators. those involved in this operation should wear rubber gloves, lab coats, & plastic aprons or equivalent protective apparel.
SECTION 7: Handling and storage
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
All bottles ... should be stored & transported within an unbreakable outer container; storage should be in ventilated storage cabinet or in hood.
SECTION 8: Exposure controls/personal protection
Control parameters
| Component | Diethylnitrosoamine | |||
|---|---|---|---|---|
| CAS No. | 55-18-5 | |||
| Limit value - Eight hours | Limit value - Short term | |||
| ppm | mg/m3 | ppm | mg/m3 | |
| Austria | ? | 0,0025 | ? | 0,01 |
| Germany (AGS) | ? | 0,0002 (1) | ? | ? |
| ? | ? | 0,0005 (2) | ? | ? |
| ? | ? | 0,001 (3) | ? | ? |
| Remarks | ||||
| Austria | TRK value (based on technical feasibility) The TRK values applies to the sum of the classified N-Nitrosamines | |||
| Germany (AGS) | Values applied to the sum of carcinogenic N-Nitrosamines (see TRGS 552). (1) Reference value that represents the state of the art for: Working with metal working fluids, volatile corrosion inhibitors (VCI), chemical industry (not stated below), foundries. (2) Reference value that represents the state of the art for: Chemical industry - working with amines, tyre industry - vulcanisation. (3) Reference value that represents the state of the art for: Chemical industry - manufacturing of polyacrylonitrile fibres, tyre industry - warehouses, technical rubber products, leather industries. | |||
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
N-nitrosodiethylamine is a clear slightly yellow liquid. Boiling point 175-177°C. Can reasonably be anticipated to be a carcinogen. Used as a gasoline and lubricant additive and as an antioxidant and stabilizer in plastics.
-
Colour：
Slightly yellow liquid
-
Odour：
no data available
-
Melting point/freezing point：
29°C(lit.)
-
Boiling point or initial boiling point and boiling range：
177°C(lit.)
-
Flammability：
no data available
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
85°C(lit.)
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
no data available
-
Solubility：
greater than or equal to 100 mg/mL at 70° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
log Kow = 0.48
-
Vapour pressure：
5.7 mm Hg at 77° F ; 8.8 mm Hg at 94.1° F (NTP, 1992)
-
Density and/or relative density：
0.95g/mL(lit.)
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
Stable at room temp for several days in aq soln @ neutral & alkaline ph; less stable @ strongly acid ph @ room temp
Possibility of hazardous reactions
N-NITROSODIETHYLAMINE reacts with strong oxidizing agents. Incompatible with reducing agents. Can be hydrolyzed by hydrogen bromide in acetic acid (NTP, 1992).
Conditions to avoid
no data available
Incompatible materials
Oxidizers, reducing agents (may form hydrazine), and hydrogen bromide. Light sensitive, rapidaly decomposes.
Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /oxides of nitrogen/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 280 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
No data are available in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 2A: The agent is probably carcinogenic to humans.
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50; Species: Pimephales promelas (Fathead Minnow); Conditions: freshwater, static, 22.0-23.0 deg C, pH 8.07-8.25, hardness 288 mg/L CaCO3, dissolved oxygen 4.8-7.0 mg/L; Concentration: 775000 ug/L for 96 hr (95% confidence interval: 698000-860000 ug/L)
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: EC50; Species: Anabaena flosaquae (Blue-Green Algae) 10000 cells; Conditions: freshwater, static, 24 deg C; Concentration: 17500 ug/L for 96 hr; Effect: growth, general
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: The concentration of N-nitrosodiethylamine (18.0 ppm nitroso-N) in lake water was essentially unchanged after 108 days incubation in the dark at 30 deg C. While the level of N-nitrosodiethylamine amended with raw sewage at pH 6.0 slowly decreased from approximately 17 ppm to 12 ppm over 14 days; the fact that the decrease was nearly the same in sterilized samples indicates that abiotic factors may have been responsible for the loss. At pH 7.2 the rate of loss was greater than for autoclaved sewage, however heat treatment may have altered sample properties so that nonbiological loss was diminished(1).
Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for N-nitrosodiethylamine(SRC), using a log Kow of 0.48(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of N-nitrosodiethylamine can be estimated to be 83(SRC). The Koc of N-nitrosodiethylamine can be estimated as 14(SRC), using a log Kow of 0.48(2) and a regression-derived equation(1). According to a classification scheme(3), these estimated Koc values suggest that N-nitrosodiethylamine is expected to have very high to high mobility in soil.
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN2810 (For reference only, please check.)
IMDG: UN2810 (For reference only, please check.)
IATA: UN2810 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: TOXIC LIQUID, ORGANIC, N.O.S. (For reference only, please check.)
IMDG: TOXIC LIQUID, ORGANIC, N.O.S. (For reference only, please check.)
IATA: TOXIC LIQUID, ORGANIC, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/