2-chloro-2'-ethyl-N-(2-methoxy-1-methylethyl)-6'-methylacetanilide SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： 2-chloro-2'-ethyl-N-(2-methoxy-1-methylethyl)-6'-methylacetanilide
- CAS： 51218-45-2
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Skin sensitization, Category 1
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
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Pictogram(s)
- Signal word Warning
H317 May cause an allergic skin reaction
H410 Very toxic to aquatic life with long lasting effects
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P273 Avoid release to the environment.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P317 If skin irritation or rash occurs: Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P391 Collect spillage.
none
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: 2-chloro-2'-ethyl-N-(2-methoxy-1-methylethyl)-6'-methylacetanilide
- Common names and synonyms: 2-chloro-2'-ethyl-N-(2-methoxy-1-methylethyl)-6'-methylacetanilide
- CAS number: 51218-45-2
- EC number: 257-060-8
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest.
Rinse and then wash skin with water and soap.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Give one or two glasses of water to drink. Refer for medical attention .
Most important symptoms/effects, acute and delayed
Can cause skin irritation and eye irritation. Headache and nausea may occur following prolong exposure. (USCG, 1999)
Indication of immediate medical attention and special treatment needed, if necessary
There is no specific antidote to counteract the toxic affects of metolachlor ... Laboratory studies have shown that metolachlor has a high affinity for activated charcoal. Therefore, if ingestion is less than 10 mg/kg body wt, it is probably best treated by administering 30-50 gm of activated charcoal in 3-4 oz of water.
SECTION 5: Firefighting measures
Suitable extinguishing media
Dry sand, alcohol-resistant foam, carbon dioxide.
Specific hazards arising from the chemical
Combustible.
Special protective actions for fire-fighters
Use dry sand, alcohol-resistant foam, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in covered containers as far as possible. Then store and dispose of according to local regulations. Personal protection: P2 filter respirator for harmful particles.
Environmental precautions
Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in covered containers as far as possible. Then store and dispose of according to local regulations. Personal protection: P2 filter respirator for harmful particles.
Methods and materials for containment and cleaning up
Remove all ignition sources. Ventilate area of spill or leak. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. Keep this chemical out of a confined space such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the build-up of explosive concentrations. ...
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from food and feedstuffs. Well closed. Provision to contain effluent from fire extinguishing.Do not contaminate water, food or feed by storage ... Keep container closed to prevent spills and contamination. Store in original container. Me-Too-Lachlor Herbicide
SECTION 8: Exposure controls/personal protection
Control parameters
no data available
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety goggles.
Protective gloves.
Use ventilation.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Metolachlor is a tan to brown oily liquid with a slightly sweet odor. Slightly soluble in water and denser than water. Hence sinks in water. Soluble in most organic solvents. Used as a selective herbicide.
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Colour：
Colorless liquid
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Odour：
no data available
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Melting point/freezing point：
-62.1 deg C
-
Boiling point or initial boiling point and boiling range：
406.8°C at 760 mmHg
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Flammability：
Combustible.
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Lower and upper explosion limit/flammability limit：
no data available
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Flash point：
greater than 230° F (USCG, 1999)
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Auto-ignition temperature：
510° F (USCG, 1999)
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Decomposition temperature：
no data available
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pH：
no data available
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Kinematic viscosity：
no data available
-
Solubility：
Miscible with benzene, toluene, ethanol, acetone, xylene, hexane, dimethylformamide, dichloroethane, cyclohexanone, methanol, octanol, and dichloromethane. Insoluble in ethylene glycol, propylene glycol, and petroleum ether.
-
Partition coefficient n-octanol/water：
log Kow = 3.13
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Vapour pressure：
3.14X10-5 mm Hg at 25 deg C
-
Density and/or relative density：
1.1 g/cm3
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Slightly soluble in water. Hydrolyzed by strong mineral acids and strong alkalis.
Chemical stability
Stable up to about 275 deg C.
Possibility of hazardous reactions
This chemical is a combustible liquid. ...METOLACHLOR is a chlorinated acetamide. May react with azo and diazo compounds to generate toxic gases. May form flammable gases with strong reducing agents. Combustion generates mixed oxides of nitrogen (NOx).
Conditions to avoid
no data available
Incompatible materials
Oxidizers, strong acids, nitrates.
Hazardous decomposition products
When heated to decompostion it emits toxic fumes of /hydrogen chloride and nitrogen oxides/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 2877 mg/kg bw
- Inhalation: LC50 Rat inhalation >2.02 mg/L/4 hr air
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Cancer Classification: Group C Possible Human Carcinogen
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50; Species: Oncorhynchus mykiss (Rainbow Trout); Conditions: freshwater, static; Concentration: 3900 ug/L for 96 hr (95% confidence interval: 3300-4600 ug/L)
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) 1st instar larva; Conditions: freshwater, static; Concentration: 25100 ug/L for 48 hr (95% confidence interval: 21600-29200 ug/L); Effect: intoxication, immobilization
- Toxicity to algae: EC50; Species: Anabaena flosaquae (Blue-Green Algae); Conditions: freshwater, static; Concentration: 1200 ug/L for 5 days (95% confidence interval: 900-1600 ug/L); Effect: population abundance /97.3% purity
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: Under aerobic soil conditions, metolachlor degraded with a half-life of 67 days in a sandy loam soil(1). The rate of degradation of metolachlor in soil increases with an increase in soil moisture content, temperature and microbial activity(2,3). The degradation of metolachlor is slower in subsoils than in surface soil(2). Five metabolites of metolachlor including 2-chloro-N-(2-ethyl-6-methylphenyl)-N-(hydroxyprop-2-yl)acetamide have been identified in soil(2). The aerobic aquatic biodegradation half-life of metolachlor was 47 days(1). The disappearance of metolachlor in groundwater free of aquifer materials (e.g., sand) was very slow(4,5). After a lag period of 10-12 months, metolachlor degraded with half-lives of 548-1074 days(5). In a study examining soils from agrochemical dealerships or railroad rights-of-way in central Iowa, rhizosphere soil samples, representing four plant families, were not able to mineralize large quantities (>8.5%) of 14C-metolachlor after 50 days(6). Samples were incubated in the dark at 20 deg C with a metolachlor concentration of 50 ug/g(6). However, in a 14-day environmental chamber study with a 14 hr photoperiod, degradation of 10 ppm metolachlor, present as a mixture with trifluralin and atrazine, was shown to occur in non-vegetated soil (27% degradation) but not to the extent of the Kochia scoparia rhizosphere soil (48% degradation), suggesting that the rhizosphere of certain plant species may facilitate microbial degradation(7). Metolachlor was not biodegraded in contaminated soil from an agrochemical dealership in Iowa, 50 ug/g initial concentration (background concentration averaged 7 ug/g) had ending concentrations of 43 to 60 ug/g metolachlor after 160 days of incubation at 25 deg C in the dark(8).
Bioaccumulative potential
A whole body BCF for metolachlor in catfish (Ictalurus melas) was experimentally determined to be <1(1). The time required to attain equilibrium in catfish was found to be 3-4 days; and the depuration half-life in catfish was 1.2 days(1). In another study, a whole body metolachlor BCF of 69 was reported for fish, with a whole body elimination of 93% after 14 days depuration(2). A whole body BCF for metolachlor in bluegill (Lepomic macrochirus) exposed for 28 days was 74(3). Catfish BCFs of metolachlor were 6.5-9.0 for edible portions and 55-99 for viscera after a 30 day exposure(4). According to a classification scheme(5), these BCF values suggest bioconcentration in aquatic organisms is low to moderate(SRC).
Mobility in soil
Koc values for metolachlor have been reported to range from 22 to 2320(1-3). In an 80 day field study using tropical soils of Brazil, Koc values were measured for metolachlor; Ustox soil (42.9-54.0% clay, 2.5-4.3% silt, 42.4-54.6% sand, 1.63-3.06% organic carbon) had an initial Koc of 186 and maximum Koc of 1530; Psamments soil (9.7-14.4% clay, 1.0-1.8% silt, 84.6-88.5% sand, 0.71-1.01% organic carbon) had an initial Koc of 122 and maximum Koc of 2320(1). Koc values for clay (4.8% organic matter, 42% clay and pH 5.9), sand (0.9% organic matter, 2.2% clay, and pH 6.5), sandy loam (5% organic matter, 9.2% clay, and pH 5.9), and loam (1.2% organic matter, 11.2% clay, and pH 7.6) soils are 68, 22, 74, and 110, respectively(2). Vegetative filter strip soil (37.9% sand, 31.9% silt, 30.2% clay, 4.2% organic carbon, pH 7.6) and cultivated soil (36.8% sand, 29.5% silt, 33.7% clay, 2.5% organic carbon, pH 7.6) from Texas had measured Koc values for metolachlor of 195.9 and 173.7, respectively(3). According to a classification scheme(4), these Koc values suggest that metolachlor is expected to have very high to slight mobility in soil(SRC). Metolachlor adsorbs more readily to muck or clay soils than to soils with low organic matter and clay content, and adsorbs more readily to organic matter than to clay(2). Experimental leaching and soil thin layer plate studies have shown that metolachlor absorbs weakly to moderately to soil and the leaching of metolachlor from soil is high to medium(5,6). In field experiments conducted with soybeans grown in Wisconsin, and corn in Iowa and California, no quantifiable metolachlor residues (limit of detection = 50 ppb) were found below 45 cm (18 in)(2). Leaching of metolachlor is generally not expected when soil organic matter is >2%(2). Leaching potentials were measured in six soil types on the Canary Island of Tenerife, potentials were 0.107 to 0.303 and is considered a leacher (> or = 0.2 to < or = 1)(7). Metolachlor had Kd values of 130.3, 32.9 and 30.9 mL/g with Bermuda grass, Weswood soil (course-silty, mixed, thermic, Fluventic Ustocherpt) and Houston black soil (fine, montmorilliontic, thermic, Udic Pellustert), respectively(8). Log Kom values ranged from 0.98 to 2.17 in 33 surface soils from Salamanca, Spain with a pH range of 4.4 to 7.7 and organic matter range of 0.43 to 2.59%(9).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN1648 (For reference only, please check.)
IMDG: UN1648 (For reference only, please check.)
IATA: UN1648 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: ACETONITRILE (For reference only, please check.)
IMDG: ACETONITRILE (For reference only, please check.)
IATA: ACETONITRILE (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 3 (For reference only, please check.)
IMDG: 3 (For reference only, please check.)
IATA: 3 (For reference only, please check.)
Packing group, if applicable
ADR/RID: II (For reference only, please check.)
IMDG: II (For reference only, please check.)
IATA: II (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Carrier solvents used in commercial formulations may change physical and toxicological properties.If the substance is formulated with solvent(s) also consult the card(s) (ICSC) of the solvent(s).