Meprobamate SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Meprobamate
- CAS： 57-53-4
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Warning
H302 Harmful if swallowed
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
none
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Meprobamate
- Common names and synonyms: Meprobamate
- CAS number: 57-53-4
- EC number: 200-337-5
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms/effects, acute and delayed
SYMPTOMS: Symptoms of exposure upon ingestion of this compound may include coma, blood pressure decrease, regional or general arteriolar constriction, dyspnea, cyanosis, respiratory depression, nausea, vomiting and allergic skin dermatitis. Other symptoms may include slight alterations of binocular vision and slight tendency to euphoria. Exposure to this compound may also cause drowsiness, diarrhea, paresthesia, weakness, headache, excitement, dizziness, ataxia, disturbances of vision, tachycardia, erythema multiform and, occasionally, skin rashes, angioneurotic edema, bronchospasm, anuria, agranulocytosis, eosinophilia, leucopenia and aplastic anemia. Other symptoms may include purpura, hypotension, cardiac arrhythmias and, occasionally, urticaria and thrombocytopenia. Exposure to this compound may result in acute intermittent porphyria, allergic or idiosyncratic reactions, slurred speech, vertigo, overstimulation, fast EEG activity, palpitations, arrhythmia, transient ECG changes, syncope, hypotensive crises, petechiae, ecchymoses, peripheral edema, adenopathy, fever, lethargy, stupor, shock, vasomotor and respiratory collapse, death, increased risk of congenital malformations and, rarely, hyperpyrexia, chills, oliguria, exfoliative dermatitis, anaphylaxis, stomatitis, proctitis, Stevens-Johnson syndrome and bullous dermatitis. Central nervous system depression may also occur. Other symptoms may include blood dyscrasias and hypothermia. Exposure to this compound also causes sleepiness, unsteadiness, mental confusion, slow and shallow respiration, flaccid muscles, hyperthermia, aspiration pneumonia, signs of lung consolidation, cerebral edema, laryngospasm, hangover emotional lability or depression, irritability, poor judgment, behavioral disturbances, vascular collapse, cardiac arrest and nonthrombocytopenic purpura. Other symptoms may include erythematous rash, angioedema, impaired stance and heart failure. In addition, areflexia, lack of response to sensory stimuli, excess oronasal secretions, relaxation of the pharyngeal wall muscular relaxation, pruritic eruptions, anaphylactoid reaction, fatal allergic collapse, fixed and unresponsive pupils, atelectasis and epileptiform seizures may occur. ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of nitrogen oxides. (NTP, 1992)
Indication of immediate medical attention and special treatment needed, if necessary
Emergency and supportive measures: Maintain an open airway and assist ventilation if necessary. Administer supplemental oxygen. Treat coma, hypothermia, hypotension, and pulmonary edema if they occur. Monitor patients for at least 6 hours after ingestion, because delayed absorption may occur. ... Sedative-hypnotic agents
SECTION 5: Firefighting measures
Suitable extinguishing media
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
Specific hazards arising from the chemical
Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
SECTION 7: Handling and storage
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Meprobamate preparations generally should be stored in tight containers at a temperature less than 40 deg C, preferably at 15-30 deg C. However, USP states that the tablets can be stored in well-closed containers. The fixed-combination tablets of meprobamate and aspirin should be stored in tight, light-resistant containers at 20-25 deg C and protected from moisture.
SECTION 8: Exposure controls/personal protection
Control parameters
no data available
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
PHYSICAL DESCRIPTION: Odorless white crystalline powder. Bitter taste. Solutions in water are neutral or slightly acidic. (NTP, 1992)
-
Colour：
Crystals from hot water
-
Odour：
Characteristic odor
-
Melting point/freezing point：
104 - 106°C
-
Boiling point or initial boiling point and boiling range：
434.2°C at 760mmHg
-
Flammability：
no data available
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
229.7°C
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
-
pH：
Aqueous solutions are neutral
-
Kinematic viscosity：
no data available
-
Solubility：
less than 1 mg/mL at 68° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
no data available
-
Vapour pressure：
3.05X10-3 mm Hg at 25 deg C (est)
-
Density and/or relative density：
1.139g/cm3
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
Stable in dil acid and alkali and not broken down in gastric or intestinal juices.
Possibility of hazardous reactions
MEPROBAMATE is a carbamate ester. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates.
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
When heated to decomp it emits toxic fumes of nitrogen oxides.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 794 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: Meprobamate has been classified as non-biodegradable(1).
Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for meprobamate(SRC), using a log Kow of 0.70(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
The Koc of meprobamate is estimated as 60(SRC), using a log Kow of 0.70(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that meprobamate is expected to have high mobility in soil.
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN1230 (For reference only, please check.)
IMDG: UN1230 (For reference only, please check.)
IATA: UN1230 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: METHANOL (For reference only, please check.)
IMDG: METHANOL (For reference only, please check.)
IATA: METHANOL (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 3 (For reference only, please check.)
IMDG: 3 (For reference only, please check.)
IATA: 3 (For reference only, please check.)
Packing group, if applicable
ADR/RID: II (For reference only, please check.)
IMDG: II (For reference only, please check.)
IATA: II (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/