Pyridazine-3,6-diol SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Pyridazine-3,6-diol
- CAS： 123-33-1
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity – single exposure, Category 3
Germ cell mutagenicity, Category 2
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Warning
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H341 Suspected of causing genetic defects
P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P203 Obtain, read and follow all safety instructions before use.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
P318 IF exposed or concerned, get medical advice.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Pyridazine-3,6-diol
- Common names and synonyms: Pyridazine-3,6-diol
- CAS number: 123-33-1
- EC number: 204-619-9
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms/effects, acute and delayed
Inhalation of dust causes irritation of nose and throat. Contact with eyes or skin causes irritation. Ingestion has been observed to cause tremors and muscle spasms in test animals. (USCG, 1999)
Indication of immediate medical attention and special treatment needed, if necessary
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal . Cover skin burns with dry, sterile dressings after decontamination . Hydrazine and Related Compounds
SECTION 5: Firefighting measures
Suitable extinguishing media
Extinguish with water, dry chemicals, foam or carbon dioxide.
Specific hazards arising from the chemical
Special Hazards of Combustion Products: Toxic nitrogen oxides are produced. (USCG, 1999)
Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Ventilate area of spill or leak. Collect for reclamation, or absorb in vermiculite, dry sand, earth, or a similar material.
SECTION 7: Handling and storage
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
De-Cut, Fair Plus, Super De-sprout have indefinite shelf life and should be stored at room temp.
SECTION 8: Exposure controls/personal protection
Control parameters
no data available
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Maleic hydrazide is an odorless white solid. Sinks in water. (USCG, 1999)
-
Colour：
Crystals from water
-
Odour：
Odorless
-
Melting point/freezing point：
142°C(lit.)
-
Boiling point or initial boiling point and boiling range：
123°C/10mmHg(lit.)
-
Flammability：
no data available
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
300°C
-
Auto-ignition temperature：
707°F
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
no data available
-
Solubility：
less than 0.1 mg/mL at 68° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
log Kow= -0.68 pH = 5; -1.96 at pH = 7; -2.41 at pH = 9
-
Vapour pressure：
0.289mmHg at 25°C
-
Density and/or relative density：
1.6
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
Very stable to both acidic & basic hydrolysis.
Possibility of hazardous reactions
MALEIC HYDRAZIDE can be decomposed by oxidizing agents. It can also be decomposed by strong acids. It forms water-soluble alkali-metal and amine salts. It is slightly acidic and may be titrated as a monobasic acid. Mild oxidation produces a compound which reacts instantly with dienes at -107° F to form crystalline derivatives. This chemical is slightly corrosive to iron and zinc. It is incompatible with pesticides that are highly alkaline in reaction. In the presence of heavy metal and iron, zinc, calcium and magnesium ions, sparingly-soluble salts are formed. (NTP, 1992)
Conditions to avoid
no data available
Incompatible materials
If in presence of strong acid, maleic hydrazide acid may precipitate. Do not use concentrate through brass nozzles as the amine content may cause erosion.
Hazardous decomposition products
When heated to decomposition it emits highly toxic fumes of /nitrogen oxides/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral >5000 mg/kg
- Inhalation: LC50 Rat inhalation >20 mg/L/1 hr
- Dermal: LD50 Rabbit percutaneous >5000 mg/kg
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Cancer Classification: Group E Evidence of Non-carcinogenicity for Humans
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50 Lepomis macrochirus (Bluegill) 1608 mg/L/96 hr /Conditions of bioassay not specified
- Toxicity to daphnia and other aquatic invertebrates: LC50 Daphnia magna 107.5 ppm /Technical maleic hydrazide, 90% ai
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
Maleic hydrazide can serve as sole source of carbon & nitrogen for number of microorganisms & ... is very subject to bacterial decomp in soil .
Bioaccumulative potential
An estimated BCF of 3 was calculated for maleic hydrazide(SRC), using a log Kow of -1.96 (1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
The reported Koc of maleic hydrazide was 264 for a clay soil, and 23 for a sand(1). Based on a classification scheme(2), these Koc values suggest that maleic hydrazide has very high to moderate mobility in soil(SRC). In a field experiment in which 5 and 10 kg/ha of maleic hydrazide were applied, the hydrazide did not migrate below a depth of 10 cm(3). This may be due to extensive biodegradation of maleic hydrazide(3). Maleic hydrazide was shown to bind to the clay component in Aiken clay loam where anion exchange is the predominant process(4). In a study of the adsorption of maleic hydrazide in 22 different soils, adsorption was most significantly correlated to specific surface area, clay content, and pH(5). The lack of correlation of adsorption with organic content of the soils may have been partly caused by the low organic content of the soils studied (<2%)(5). Adsorption of the herbicide ranged from high to low(5). Based upon the above information, maleic hydrazide may generally be expected to be mobile in soils with low clay content and relatively immobile in soils with high clay content. The mobility also may be affected by pH and specific surface area of the soils(SRC).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN3428 (For reference only, please check.)
IMDG: UN3428 (For reference only, please check.)
IATA: UN3428 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: 3-CHLORO-4-METHYLPHENYL ISOCYANATE, SOLID (For reference only, please check.)
IMDG: 3-CHLORO-4-METHYLPHENYL ISOCYANATE, SOLID (For reference only, please check.)
IATA: 3-CHLORO-4-METHYLPHENYL ISOCYANATE, SOLID (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: II (For reference only, please check.)
IMDG: II (For reference only, please check.)
IATA: II (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/