Methoxychlor SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Methoxychlor
- CAS： 72-43-5
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Specific target organ toxicity – single exposure, Category 2
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
GHS label elements, including precautionary statements
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Pictogram(s)
- Signal word Warning
H302 Harmful if swallowed
H371 May cause damage to organs
H400 Very toxic to aquatic life
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P308+P316 IF exposed or concerned: Get emergency medical help immediately.
P391 Collect spillage.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Methoxychlor
- Common names and synonyms: Methoxychlor
- CAS number: 72-43-5
- EC number: 200-779-9
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest.
Remove contaminated clothes. Rinse and then wash skin with water and soap.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give one or two glasses of water to drink. Refer for medical attention .
Most important symptoms/effects, acute and delayed
Toxicity is relatively low. Inhalation or ingestion causes generalized depression. (USCG, 1999)
Indication of immediate medical attention and special treatment needed, if necessary
Observation. Persons exposed to high levels of organochlorine pesticides by any route should be observed for sensory disturbances, incoordination, speech slurring, mental aberrations, and involuntary motor activity that would warn of imminent convulsions. Solid organochlorine insecticides
SECTION 5: Firefighting measures
Suitable extinguishing media
Water, foam, dry chemical, or carbon dioxide.
Specific hazards arising from the chemical
Special Hazards of Combustion Products: Irritating and toxic hydrogen chloride gas may be formed in fire. (USCG, 1999)
Special protective actions for fire-fighters
Use water spray, powder, alcohol-resistant foam, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.
Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.
Methods and materials for containment and cleaning up
SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a POTW is acceptable only after review by the governing authority. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must meet Hazardous Material Criteria for disposal.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from food and feedstuffs. Well closed. Keep in a well-ventilated room.Storage temperature: ambient
SECTION 8: Exposure controls/personal protection
Control parameters
TLV: 10 mg/m3, as TWA; A4 (not classifiable as a human carcinogen).MAK: (inhalable fraction): 1 mg/m3; peak limitation category: II(8); skin absorption (H); pregnancy risk group: B
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety spectacles or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
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Physical state：
Methoxychlor is a white crystalline solid which is often dissolved in a liquid carrier such as diesel oil. It can cause illness by inhalation, skin absorption and/or ingestion. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. If dissolved in a liquid carrier, it can easily penetrate the soil and contaminate groundwater and nearby streams. It is used as a pesticide.
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Colour：
Colorless crystals (technical, grey powder)
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Odour：
Slight, fruity odor
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Melting point/freezing point：
86-88°C(lit.)
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Boiling point or initial boiling point and boiling range：
greater than or equal to 100°C.
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Flammability：
Combustible Solid, but difficult to burn.
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Lower and upper explosion limit/flammability limit：
no data available
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Flash point：
less than 60 degrees°C
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Auto-ignition temperature：
no data available
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Decomposition temperature：
no data available
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pH：
no data available
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Kinematic viscosity：
no data available
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Solubility：
less than 1 mg/mL at 73° F (NTP, 1992)
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Partition coefficient n-octanol/water：
log Kow = 5.08
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Vapour pressure：
Very low (NTP, 1992)
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Density and/or relative density：
1.4 g/cm3
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Relative vapour density：
12 (NTP, 1992) (Relative to Air)
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Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
NIOSH considers methoxychlor to be a potential occupational carcinogen.
Decomposes on heating and on burning. This produces toxic and corrosive gases including hydrogen chloride (see ICSC 0163). Reacts with oxidants. Attacks some plastics and rubber.
Chemical stability
Stable to UV light.
Possibility of hazardous reactions
The material is a combustible solid, but difficult to ignite.METHOXYCHLOR turns pink or tan on exposure to light. This chemical is incompatible with alkaline materials, especially in the presence of catalytically-active metals. It is slightly corrosive to iron and aluminum. It is decomposed by refluxing with sodium in isopropyl alcohol. It is also incompatible with strong oxidizers. It will attack some forms of plastics, rubber and coatings. (NTP, 1992).
Conditions to avoid
no data available
Incompatible materials
Contact with strong oxidizers may cause fires and explosions.
Hazardous decomposition products
When heated to decomp, it emits highly toxic fumes of /hydrogen chloride/ .
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 6000 mg/kg Technical material
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Classification of carcinogenicity: 1) evidence in humans: no data; 2) evidence in animals: insufficient. Overall summary evaluation of carcinogenic risk to humans is Group 3: The agent is not classifiable as to its carcinogenicity to humans. From table
Reproductive toxicity
No information is available on the reproductive or developmental effects of methoxychlor in humans. Methoxychlor and its metabolites possess estrogenic properties. Reproductive and developmental effects have been reported in animals orally exposed to methoxychlor. (4,6) Effects to the development of the female reproductive system, gross and histopathological changes in the male and female reproductive systems, effects on male and female reproductive function (i.e., decreased fertility in males and females, decreased spermatogenesis, and interference with estrus cycling), and changes to hormone levels have been reported in orally exposed animals. (4) In rabbits orally exposed to methoxychlor, excessive loss of litters (abortions) was observed. (6) Skeletal effects were observed in the offspring of rats exposed to methoxychlor by gavage (experimentally placing the chemical in the stomach). (4,6) Long-term oral exposure to methoxychlor has been reported to increase fetotoxicity in animals, as well as to affect the reproductive development and reduce the fertility of offspring. (4,6)
STOT-single exposure
no data available
STOT-repeated exposure
Animal tests show that this substance possibly causes toxic effects upon human reproduction.
Aspiration hazard
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying or when dispersed, especially if powdered.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill, weight 0.6 g); Conditions: freshwater, flow through, 18 deg C, pH 7.4, hardness 272 mg/L CaCO3; Concentration: 100 ug/L for 24 hr (95% confidence limit 62-162 ug/L) /98% purity, technical material
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea, age <24 hr); Conditions: freshwater, static; Concentration: 1800 ug/L for 48 hr (95% confidence interval: 1500-2100 ug/L); Effect: intoxication, immobilization /40% purity
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: First-order rate constants of 0.001 to 0.004 (half-life of 7 to 29 days), 0.002 to 0.003 (half-life of 9.6 to 14.4 days), 0.001 to 0.006 (half-life of 4.8 to 29 days), and 0.002 to 0.004 per hour (half-life of 7 to 14.4 days) were measured for methoxychlor added to 4 different freshwaters(1). In an aerobic die-away study using water from the Santa Rosa Sound, FL, methoxychlor had a half-life of >25 days(2). In an aerobic shake-flask river die-away test, methoxychlor was biodegraded in a mixed water/sediment sample, rate not given(3). The degradation of methoxychlor in 2 sandy loam soils was dependent on water content; soils with 3% and 10% water content degraded methoxychlor to only trace amounts within 30 to 38 and 20 to 26 weeks, respectively(4). Methoxychlor applied to soil during a 2-year field study was fairly persistent; residues remaining after 1, 2, and 3 months made up 92, 38, and 27% of the original application(5). One year later, measurable concentrations of methoxychlor were still present in soil as well as products from the partial dechlorination of the parent compound(5). Second-order rate constants of 5.2X10-14 and 6.1X10-16 liters per organism-hr (half-lives of 111 and 9500 days, respectively, assuming a bacterial concentration of 5X10+9 organisms/L) were measured dependent on 15% and 90% sorption, respectively, to sediments in river die-away studies(6).
Bioaccumulative potential
Bioconcentration factors (BCF) for methoxychlor of 8300 in fathead minnow (Pimephales promelas)(1) and 138 in sheepshead minnow (Cyprinodon variegatus)(4) have been measured in continuous flow systems. According to a classification scheme(6), these BCF values suggest that bioconcentration in aquatic organisms is high to very high(SRC). However, as seen in the BCF from the sheepshead minnow study, some variation between species in the ability to metabolize this compound may exist(7-9). Bioconcentration factors (BCF) for methoxychlor of 12,000 in mussel(2), 5000-8570 in snail (Physa integra), 348-1130 in stonefly (Pteronarcys dorsata)(3) and 1500 in soft clams (Mya avenaria)(5) have also been measured in continuous flow systems.
Mobility in soil
Measured average sorption coefficient (Koc) values in various pond and river sediments are as follows: 23,000 in sand, 82,000 in coarse silt, 88,000 in medium silt, 93,000 in fine silt and 83,000 in clay(1). In another study, a K value of 620 was found in a water-sediment system(2). Another study determined a K value of 2009 in soil(3). According to a classification scheme(4), these Koc values suggest that methoxychlor is expected to be immobile in soil. Mass balances in pond, river and wet sand (25% moisture) systems spiked with methoxychlor indicate that 98.6, 97.0, and 92.1%, respectively, of all methoxychlor was retained in the sediment(5).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN2811 (For reference only, please check.)
IMDG: UN2811 (For reference only, please check.)
IATA: UN2811 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)
IMDG: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)
IATA: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Ingestion in large amounts may cause effects on the liver, kidneys and central nervous system.Temperature of decomposition is unknown in the literature.Depending on the degree of exposure, periodic medical examination is suggested.If the substance is formulated with solvent(s) also consult the card(s) (ICSC) of the solvent(s).Carrier solvents used in commercial formulations may change physical and toxicological properties.See ICSC 0034.