Isophthalic acid SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Isophthalic acid
- CAS： 121-91-5
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
- Signal word No signal word
none
none
none
none
none
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Isophthalic acid
- Common names and synonyms: Isophthalic acid
- CAS number: 121-91-5
- EC number: 204-506-4
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest.
Remove contaminated clothes. Rinse skin with plenty of water or shower.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth.
Most important symptoms/effects, acute and delayed
May cause slight to moderate irritation of eyes, skin, and mucous membranes on prolonged contact. Ingestion may cause gastrointestinal irritation. (USCG, 1999)
Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Poisons A and B
SECTION 5: Firefighting measures
Suitable extinguishing media
Fire Extinguishing Agents: Water, dry powder, foam, carbon dioxide (USCG, 1999)
Specific hazards arising from the chemical
Behavior in Fire: Dust forms explosive mixture in air. (USCG, 1999)
Special protective actions for fire-fighters
Use water spray, foam, powder, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
SECTION 8: Exposure controls/personal protection
Control parameters
MAK: (inhalable fraction): 5 mg/m3; peak limitation category: I(2); pregnancy risk group: C
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety spectacles.
Protective gloves.
Use local exhaust.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Solid. Crystalline powder.
-
Colour：
White, when purified to the grade required for use as a polyester feedstock.
-
Odour：
no data available
-
Melting point/freezing point：
>= 345 - <= 348 °C. Atm. press.:> 1 atm. Remarks:Melting point determined by the closed tube method [Ref. Doc. Table 24]. Sublimation occurs under normal atmospheric pressure; heat of sublimation at 25 degrees C is given as 106.7 kJ/mol. Sublimation temperature not stated.
-
Boiling point or initial boiling point and boiling range：
348 °C. Atm. press.:> 760 mm Hg. Remarks:The melting point of IPA under sealed tube conditions was 345 to 348 degrees C.
-
Flammability：
Combustible.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
107°C(lit.)
-
Auto-ignition temperature：
>650°C
-
Decomposition temperature：
no data available
-
pH：
3.5. Remarks:PH measured.;3.43. Remarks:PH measured.;3.33. Remarks:PH measured.
-
Kinematic viscosity：
0.00025186 Pa-s at 619.15K (346 deg C)
-
Solubility：
Soluble in 8000 parts cold water, 460 parts boiling water; freely soluble in alcohol; practically insoluble in petroleum ether
-
Partition coefficient n-octanol/water：
log Pow = 1.76. Remarks:Temp and pH not relevant as theoretical result.
-
Vapour pressure：
Ca. 0 mm Hg. Temperature:Ca. 25 °C. Remarks:The vapour pressure at 25 degrees C is extrapolated beyond the range of the data used to construct the equation relating VP to temperature. Nevertheless, the estimate is very low compared to standard atmospheric pressure.
-
Density and/or relative density：
1.53 g/cm3. Temperature:25 °C.
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Dust forms explosive mixture in air (USCG, 1999).
Chemical stability
Sublimes without decomp
Possibility of hazardous reactions
Dust explosion possible if in powder or granular form, mixed with air.ISOPHTHALIC ACID is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in it to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
When heated to decomposition it emits acrid smoke and fumes.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 12200 mg/kg bw
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
May cause mechanical irritation to the eyes.
STOT-repeated exposure
no data available
Aspiration hazard
Evaporation at 20°C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50 - Leuciscus idus melanotus - > 907 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - > 952 mg/L - 48 h.
- Toxicity to algae: NOEC - Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) - 1 000 mg/L - 96 h.
- Toxicity to microorganisms: EC50 - activated sludge of a predominantly domestic sewage - 617.1 mg/L - 3 h. Remarks:Respiration rate.
Persistence and degradability
AEROBIC: Isophthalic acid, present at 100 mg/L, reached 78 of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test indicating ready biodegradability(1). Under aerobic conditions and following OECD guideline 301B, approximately 9%, 46%, 64%, and 77% of isophthalic acid contained in sludge was degraded after 2, 5, 7, and 12 days, respectively(2). Isophthalic acid is degraded by aerobic microorganisms isolated from soil and marine sediment(3,4); cultures isolated from marine cultures also degraded isophthalic acid under anaerobic conditions(4). After an acclimation to an activated sludge inoculum over a 24 day period, 84% of isophthalate was consumed in a respiratory test(5). Isophthalic acid completely degraded in 8 days in a biodegradation test that used a soil inoculum(6). In another screening test, 95% of COD was removed in 5 days using an acclimated activated sludge inoculum(7). In anaerobic biodegradation tests using granular and digested sewage sludge inoculum, isophthalic acid (as isophthalate) could be completely mineralized with a lag phase for 50% degradation ranging from 74 to 156 days(8). Using bacteria from river water as inocula (Songhua River, China) and a sealed-bottled method, isophthalic acid was found to be readily biodegradable with first-order rate constant of 1.43/day(9).
Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for isophthalic acid(SRC), using a log Kow of 1.66(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.
Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of isophthalic acid can be estimated to be 79(SRC). According to a classification scheme(2), this estimated Koc value suggests that isophthalic acid is expected to have high mobility in soil(SRC). Isophthalic acid is a dibasic (2 displaceable hydrogen atoms) acid whose pKa1 is 3.70 and pKa2 is 4.60 at 25 deg C(3) indicating that isophthalic acid will be largely dissociated in the environment in the anion form and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Packing group, if applicable
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Sublimes without decomposition.