Isoniazid SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Isoniazid
- CAS： 54-85-3
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Skin irritation, Category 2
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Warning
H302 Harmful if swallowed
H315 Causes skin irritation
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
none
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Isoniazid
- Common names and synonyms: Isoniazid
- CAS number: 54-85-3
- EC number: 200-214-6
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest.
Remove contaminated clothes. Rinse and then wash skin with water and soap.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .
Most important symptoms/effects, acute and delayed
SYMPTOMS: Symptoms of exposure to this compound include irritation of the skin, peripheral nerve sensory changes, somnolence, anorexia, sweating, respiratory depression, urine changes and toxic psychosis. Other symptoms include dizziness, paresthesias, fatal hepatitis, metabolic acidosis, convulsions and coma. It can cause headache, muscle twitching, deafness, polyneuritis, paralysis and pyridoxine deficiency. It can also cause nausea, vomiting, atropinic signs such as mydriasis, brightly colored lights and other visual hallucinations, tachycardia, peripheral neuropathy, other central nervous system reactions, stupor, exhaustion, urinary retention, liver damage, bone marrow damage and death. Exposure may cause fatigue, weakness, malaise, toxic encephalopathy, optic neuritis, optic atrophy, memory impairment, epigastric distress, elevated serum transaminases (SGOT, SGPT), bilirubinemia, bilirubinuria, jaundice, agranulocytosis hemolytic anemia, sideroblastic anemia, aplastic anemia, thrombocytopenia, eosinophilia, fever, skin eruptions (morbilliform, maculopapular, purpuric or exfoliative), lymphadenopathy, vasculitis, pellagra, hyperglycemia, gynecomastia, rheumatic syndrome, systemic lupus erythematosus-like syndrome, blurred vision, respiratory distress, central nervous system depression, severe and intractable seizures and acetonuria. Exposure may also cause gastrointestinal effects, liver necrosis, slight euphoria, irritability, nervousness, insomnia, excessive dreaming and giddiness. Other symptoms include peripheral neuritis, burning of the feet, reduction of central vision and papilledema. Hyperreflexia, vertigo, ataxia, tinnitus, hepatic reactions, hypersensitivity reactions and lethargy may occur. Constipation, difficulty in starting urination, dryness of the mouth, mood-elevating effect and mental disturbances, ranging from minor personality changes to major mental derangements. This compound may also cause skin rash, urticaria, arthritic symptoms such as back pain, bilateral proximal interphalangeal joint involvement, arthralgia of the knees, elbows and wrists and "shoulder-hand" syndrome; separation of ideas and reality, florid psychosis, loss of self-control, excessive sedation, incoordination and methemoglobinemia. ACUTE/CHRONIC HAZARDS: This compound is an irritant of the skin, eyes, mucous membranes and upper respiratory tract. It is harmful by ingestion, inhalation and skin absorption. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides, ammonia and partially oxidized hydrocarbons. (NTP, 1992)
Indication of immediate medical attention and special treatment needed, if necessary
Emergency and supportive measures; 1. Maintain an open airway and assist ventilation if necessary. 2. Treat coma, seizures, and metabolic acidosis if they occur. Administer diazepam, 0.1-0.2 mg/kg IV, for treatment of seizures.
SECTION 5: Firefighting measures
Suitable extinguishing media
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)
Specific hazards arising from the chemical
This chemical is combustible. (NTP, 1992)
Special protective actions for fire-fighters
Use water spray, powder, foam, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: P2 filter respirator for harmful particles.
Environmental precautions
Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: P2 filter respirator for harmful particles.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Cool. Well closed.Store below 40 deg C (104 deg C), preferably between 15 and 30 deg C (59 and 86 deg F), unless otherwise specified by manufacturer. Store in a tight, light-resistant container. Protect from freezing. NOTE: Crystallization may occur at low temperatures. Upon warming to room temperature, the crystals will redissolve.
SECTION 8: Exposure controls/personal protection
Control parameters
no data available
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety spectacles.
Protective gloves.
Use local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
PHYSICAL DESCRIPTION: Odorless colorless or white crystals or white crystalline powder. Taste is slightly sweet at first and then bitter. pH (1% aqueous solution) 5.5-6.5. pH (5% aqueous solution) 6-8. (NTP, 1992)
-
Colour：
COLORLESS OR WHITE CRYSTALS, OR A WHITE, CRYSTALLINE POWDER
-
Odour：
no data available
-
Melting point/freezing point：
-8°C(lit.)
-
Boiling point or initial boiling point and boiling range：
212°C(lit.)
-
Flammability：
Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
75°C(lit.)
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
-
pH：
pH of a 1% aqueous solution 5.5 to 6.5
-
Kinematic viscosity：
no data available
-
Solubility：
13.7 [ug/mL]
-
Partition coefficient n-octanol/water：
no data available
-
Vapour pressure：
Negligible (NTP, 1992)
-
Density and/or relative density：
1.244g/cm3
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on heating and on burning. This produces toxic fumes including nitrogen oxides.
Chemical stability
Stable at room temp for more than 14 days in aq soln and more than 6 wk when stored at about 4 deg c.
Possibility of hazardous reactions
ISONIAZID is incompatible with chloral, aldehydes, iodine, hypochlorites and ferric salts. It is also incompatible with oxidizers. It may react with sugars and ketones. It can react as a weak acid or a weak base. It can be decomposed by oxidative and reductive reactions. (NTP, 1992)
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 650 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Inadequate evidence of carcinogenicity in humans. Limited evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.
Reproductive toxicity
no data available
STOT-single exposure
The substance may cause effects on the nervous system and kidneys. This may result in disorientation, lethargy, coma and metabolic acidosis. Exposure at high levels could cause death. Exposure could cause unconsciousness.
STOT-repeated exposure
The substance may have effects on the central nervous system and liver. This may result in tissue lesions and impaired functions.
Aspiration hazard
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Packing group, if applicable
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Many trade names are known for this compound.