Hexachlorophene SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Hexachlorophene
- CAS： 70-30-4
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 3, Dermal
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H301 Toxic if swallowed
H311 Toxic in contact with skin
H410 Very toxic to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P273 Avoid release to the environment.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P391 Collect spillage.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Hexachlorophene
- Common names and synonyms: Hexachlorophene
- CAS number: 70-30-4
- EC number: 200-733-8
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Rinse with plenty of water (remove contact lenses if easily possible).
Rinse mouth. Rest. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention.
Most important symptoms/effects, acute and delayed
Inhalation of dust is poisonous; irritating to mucous membranes. Eye and skin irritant. Poisonous if swallowed. Symptoms following ingestion include anorexia, nausea, vomiting, abdominal cramps, and diarrhea. Dehydration may be severe and may be associated with shock. (USCG, 1999)
Indication of immediate medical attention and special treatment needed, if necessary
Other therapies. Though this compound is quite toxic systemically and enhanced clearance methods would appear beneficial, there is no evidence to support the efficacy of hemodialysis, peritoneal dialysis, hemoperfusion, or exchange transfusion.
SECTION 5: Firefighting measures
Suitable extinguishing media
If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical or carbon dioxide. Keep run-off waste out of sewers and water sources.
Specific hazards arising from the chemical
Special Hazards of Combustion Products: Contain toxic and irritating chloride fumes. Behavior in Fire: Decomposes to produce toxic and irritating gases. (USCG, 1999)
Special protective actions for fire-fighters
Use water spray, powder, foam, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from food and feedstuffs. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.Store at room temperature up to 25 deg C (77 deg F).
SECTION 8: Exposure controls/personal protection
Control parameters
no data available
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear face shield.
Protective gloves. Protective clothing.
Use local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Hexachlorophene is a white free-flowing odorless powder. Insoluble in water and denser than water. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion. Used to make other chemicals.
-
Colour：
Crystals from benzene
-
Odour：
ODORLESS OR HAS ONLY SLIGHTLY PHENOLIC ODOR
-
Melting point/freezing point：
160 - 166°C
-
Boiling point or initial boiling point and boiling range：
166°C
-
Flammability：
Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
238.6°C
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
no data available
-
Solubility：
less than 1 mg/mL at 68° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
7.54 (calculated)
-
Vapour pressure：
8.3X10-11 mm Hg at 25 deg C (est)
-
Density and/or relative density：
1.713g/cm3
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on heating and on burning. This produces toxic and irritating fumes including hydrogen chloride. Reacts with strong oxidants.
Chemical stability
no data available
Possibility of hazardous reactions
HEXACHLOROPHENE is incompatible with strong oxidizers. It forms salts with alkalis and alkaline earths. (NTP, 1992)
Conditions to avoid
no data available
Incompatible materials
Oxidizers.
Hazardous decomposition products
When heated to decomposition, it emits highly toxic fumes of ... /hydrogen chloride/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 56 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Classification of carcinogenicity: 1) evidence in humans: no data; 2) evidence in animals: inadequate. Overall summary evaluation of carcinogenic risk to humans is Group 3: The agent is not classifiable as to its carcinogenicity to humans. From table
Reproductive toxicity
no data available
STOT-single exposure
The substance may cause effects on the nervous system and optic nerve. This may result in cardiac disorders, respiratory failure and blindness. The effects may be delayed up to 48 hours. Medical observation is indicated.
STOT-repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the nervous system and optic nerve. This may result in tissue lesions and blindness. May cause toxicity to human reproduction or development.
Aspiration hazard
A nuisance-causing concentration of airborne particles can be reached quickly when dispersed.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50; Species: Pimephales promelas (Fathead minnow) age 30 days, length 20.1 mm, weight 0.103 g; Conditions: freshwater, flow through, 24.3 deg C, pH 7.30, hardness 51.1 mg/L CaCO3, alkalinity 45.8 mg/L CaCO3, dissolved oxygen 5.8 mg/L; Concentration: 21 ug/L for 96 hr (95% confidence interval: 19-23 ug/L) /99% purity
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age <24 hr neonate; Conditions: freshwater, static, 21 deg C, pH 7.6; Concentration: 0.000487 mM for 24 hr; Effect: intoxication, immobilization
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: Hexachlorophene, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Radio-labeled C14-hexachlorophene was not biodegraded in surface water from the Skidaway River, GA(2). In sediments from Skidaway River, radio-labeled C14-hexachlorophene was degraded with a half-life of 290 days(2).
Bioaccumulative potential
The BCF of hexachlorophene in carp (Cyprinus carpio), exposed for 8 weeks to 2 and 0.2 ug/L were 87-148 and 82-153, respectively(1). BCFs for hexachlorophene in mosquito fish (Gambusia affinis) and snails (Physa sp) are 278 and 970, respectively(2). According to a classification scheme(3), these BCFs suggest the potential for bioconcentration in aquatic organisms is moderate to high(SRC).
Mobility in soil
The Koc of hexachlorophene has been reported as 91,000(1). According to a classification scheme(2), this Koc value suggests that hexachlorophene is expected to be immobile in soil. The pKa of hexachlorophene is 4.95(3), indicating that this compound will partially exist in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). A study of the mobility in Hagerstown silty clay loam soil TLC (thin layer chormatography) plates using 10 soil fungi and an alga (range of Rf values, 0.01-0.04, avg 0.01) indicated very little movement on the soil TLC plates(5). A monitoring study identified hexachlorophene in humic acid fractions of two sediment samples taken at least eight years after the FDA ban on the over-the-counter sale of cosmetics and drugs containing more than 0.1% hexachlorophene(6). These data indicate that hexachlorophene was strongly associated with organic matter which may have been as a result of covalent binding of the ionizable compound(5-6).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN2875 (For reference only, please check.)
IMDG: UN2875 (For reference only, please check.)
IATA: UN2875 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: HEXACHLOROPHENE (For reference only, please check.)
IMDG: HEXACHLOROPHENE (For reference only, please check.)
IATA: HEXACHLOROPHENE (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/