Dimethyl fumarate SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Dimethyl fumarate
- CAS： 624-49-7
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 4, Dermal
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Warning
H312 Harmful in contact with skin
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P302+P352 IF ON SKIN: Wash with plenty of water/...
P317 Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
none
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Dimethyl fumarate
- Common names and synonyms: Dimethyl fumarate
- CAS number: 624-49-7
- EC number: 210-849-0
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Seek medical attention if you feel unwell.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention if skin irritation occurs.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth.
Most important symptoms/effects, acute and delayed
no data available
Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Poisons A and B
SECTION 5: Firefighting measures
Suitable extinguishing media
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Specific hazards arising from the chemical
Combustible. Finely dispersed particles form explosive mixtures in air.
Special protective actions for fire-fighters
Use water spray, foam, powder, alcohol-resistant foam. In case of fire: keep drums, etc., cool by spraying with water.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. If appropriate, moisten first to prevent dusting. Sweep spilled substance into sealable containers. Then store and dispose of according to local regulations. Wash away remainder with plenty of water.
Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. If appropriate, moisten first to prevent dusting. Sweep spilled substance into sealable containers. Then store and dispose of according to local regulations. Wash away remainder with plenty of water.
Methods and materials for containment and cleaning up
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. If appropriate, moisten first to prevent dusting. Sweep spilled substance into sealable containers. Then store and dispose of according to local regulations. Wash away remainder with plenty of water.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Prevent build-up of electrostatic charges (e.g., by grounding). Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Keep in a well-ventilated room. Well closed. Keep in the dark. Separated from strong oxidants.Store at 15 deg C to 30 deg C (59 to 86 deg F). Protect the capsules from light. Store in original container.
SECTION 8: Exposure controls/personal protection
Control parameters
no data available
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety goggles.
Protective gloves.
Avoid inhalation of dust.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
WHITE CRYSTALLINE POWDER.
-
Colour：
White to off-white powder
-
Odour：
no data available
-
Melting point/freezing point：
33°C(lit.)
-
Boiling point or initial boiling point and boiling range：
205°C(lit.)
-
Flammability：
Combustible.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
113°C(lit.)
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
no data available
-
Solubility：
Highly soluble in water.
-
Partition coefficient n-octanol/water：
log Kow = 0.74
-
Vapour pressure：
0.114 mm Hg at 25 deg C (est)
-
Density and/or relative density：
1.124 g/cm3
-
Relative vapour density：
(air = 1): 5
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Reacts with strong oxidants. This generates fire and explosion hazard. The substance can form explosive peroxides on prolonged contact with air and light.
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
Combustible.If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc.
Conditions to avoid
no data available
Incompatible materials
Reacts with strong oxidants. This generates fire and explosion hazard. The substance can form explosive peroxides on prolonged contact with air and light.
Hazardous decomposition products
When heated to decomposition it emits acrid smoke and irritating fumes.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 2240 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is irritating to the skin and respiratory tract. The substance is severely irritating to the eyes.
STOT-repeated exposure
Repeated or prolonged contact with skin may cause dermatitis.
Aspiration hazard
A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
no data available
Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for dimethyl fumarate(SRC), using a log Kow of 0.74(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
The Koc of dimethyl furmarate is estimated as 16(SRC), using a log Kow of 0.74(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that dimethyl furmarate is expected to have very high mobility in soil.
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN3265 (For reference only, please check.)
IMDG: UN3265 (For reference only, please check.)
IATA: UN3265 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S. (For reference only, please check.)
IMDG: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S. (For reference only, please check.)
IATA: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 8 (For reference only, please check.)
IMDG: 8 (For reference only, please check.)
IATA: 8 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Products containing more than 0.1% Dimethylfumarate are banned from the market in EU countries.