Diethylstilbestrol SDS

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity – single exposure, Category 3

Carcinogenicity, Category 1B

Reproductive toxicity, Category 1B

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

H315 Causes skin irritation

H319 Causes serious eye irritation

H335 May cause respiratory irritation

H350 May cause cancer

H360 May damage fertility or the unborn child

H410 Very toxic to aquatic life with long lasting effects

P264 Wash ... thoroughly after handling.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P203 Obtain, read and follow all safety instructions before use.

P273 Avoid release to the environment.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P321 Specific treatment (see ... on this label).

P332+P317 If skin irritation occurs: Get medical help.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P319 Get medical help if you feel unwell.

P318 IF exposed or concerned, get medical advice.

P391 Collect spillage.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

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Fresh air, rest. Half-upright position. Refer immediately for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower for at least 15 minutes. Refer immediately for medical attention.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Give nothing to drink. Refer immediately for medical attention.

SYMPTOMS: Symptoms of exposure to this compound via ingestion include dysmenorrhea, premenstrual-like syndrome, amenorrhea (during and after), increase in size of uterine fibromyomata, vaginal candidiasis, change in cervical eversion and of cervical secretion, cystitis-like syndrome; tenderness, enlargement and secretion of the breasts; abdominal cramps, bloating, cholestatic jaundice, chloasma or melasma, erythema multiforme, erythema nodosum, loss of scalp hair hemorrhagic eruptions, hirsutism, steepening of corneal curvature, intolerance to contact lenses, headache, migraine, dizziness, mental depression, chorea, decrease or increase in weight, reduced carbohydrate tolerance, aggravation of porphyria, edema and changes in libido. Gynaecomastia is the main side effect in the male. Exposure may also cause proliferation and withdrawal bleeding, sodium retention, nitrogen retention, alterations in liver function, jaundice, nausea and vomiting. It can cause male impotence and transsexual changes. It may also cause congenital malformation in the fetus. Human reproductive effects by ingestion include abnormal spermatogenesis, changes in the testes, epididymis and sperm duct; menstrual cycle changes or disorders, changes in female fertility, developmental abnormalities of the fetal urogenital system, germ cell effects in offspring and delayed effects in the newborn. ACUTE/CHRONIC HAZARDS: This chemical may be harmful if swallowed or inhaled. It may cause irritation of the skin, eyes, mucous membranes and upper respiratory tract. When heated to decomposition it emits toxic fumes of carbon monoxide and carbon dioxide. (NTP, 1992)

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Monitor for shock and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool . Cover skin burns with dry sterile dressings after decontamination . Poisons A and B

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

Wear self-contained breathing apparatus for firefighting if necessary.

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. Chemical Carcinogens

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from food and feedstuffs. Dry. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens

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Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

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Decomposes on heating. This produces flammable and toxic fumes. Reacts violently with ammonia, strong oxidants, strong bases and powdered metals. This generates fire hazard. Reacts with water and moisture. This produces sulfuric acid and ethanol.

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DIETHYLSTILBESTROL is incompatible with strong oxidizing agents, strong bases, acid chlorides and acid anhydrides (NTP, 1992).

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When heated to decomposition it emits acrid smoke and fumes.

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The Human Health Assessment Group in EPA's Office of Health and Environmental Assessment has evaluated diethylstilbestrol for carcinogenicity. According to their analysis, the weight-of-evidence for diethylstilbestrol is group A, which is based on sufficient evidence in humans and sufficient evidence in animals. As a group A chemical, diethylstilbestrol is considered carcinogenic to humans.

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AEROBIC: Over a period of 6 days under aerobic conditions at 20 deg C, 500 mg/l diethylstilbestrol was resistant to biodegradation in two activated sludge samples and was slightly inhibitory in a third sample(1). Biodegradation studies of diethylstilbestrol have indicated this hormone is persistant in soil and feces(2).

An estimated BCF of 1600 was calculated for diethylstilbestrol(SRC), using a log Kow of 5.07(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is very high if diethylstilbestrol is not metabolized.

Using a structure estimation method based on molecular connectivity indices(1), the Koc for diethylstilbestrol can be estimated to be 570,000(SRC). According to a classification scheme(2), this estimated Koc value suggests that diethylstilbestrol is expected to be immobile in soil.

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The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN3077 (For reference only, please check.)

IMDG: UN3077 (For reference only, please check.)

IATA: UN3077 (For reference only, please check.)

ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)

IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)

IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)

ADR/RID: 9 (For reference only, please check.)

IMDG: 9 (For reference only, please check.)

IATA: 9 (For reference only, please check.)

ADR/RID: III (For reference only, please check.)

IMDG: III (For reference only, please check.)

IATA: III (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

no data available

no data available