Diethyl sulphate SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Diethyl sulphate
- CAS： 64-67-5
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Acute toxicity - Category 4, Dermal
Skin corrosion, Sub-category 1B
Acute toxicity - Category 4, Inhalation
Germ cell mutagenicity, Category 1B
Carcinogenicity, Category 1B
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H302 Harmful if swallowed
H312 Harmful in contact with skin
H314 Causes severe skin burns and eye damage
H332 Harmful if inhaled
H340 May cause genetic defects
H350 May cause cancer
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P203 Obtain, read and follow all safety instructions before use.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P317 Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316 Get emergency medical help immediately.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P318 IF exposed or concerned, get medical advice.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Diethyl sulphate
- Common names and synonyms: Diethyl sulphate
- CAS number: 64-67-5
- EC number: 200-589-6
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Half-upright position. Refer immediately for medical attention.
Remove contaminated clothes. Rinse skin with plenty of water or shower for at least 15 minutes. Refer immediately for medical attention.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Do NOT induce vomiting. Give nothing to drink. Refer immediately for medical attention.
Most important symptoms/effects, acute and delayed
May be fatal if inhaled, swallowed or absorbed through skin. Inhalation causes nausea and vomiting. Causes burns to skin and eyes. Ingestion may cause nausea, vomiting abdominal pain and collapse. (USCG, 1999)
Indication of immediate medical attention and special treatment needed, if necessary
For basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary. Anticipate seizures and treat if necessary. Monitor for shock and treat if necessary. For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport. Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal. Cover skin burns with sterile dressings after decontamination. Sulfur and related compounds
SECTION 5: Firefighting measures
Suitable extinguishing media
Use dry chemical, foam, carbon dioxide, or water spray. Use water spray to keep fire-exposed containers cool. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products.
Specific hazards arising from the chemical
Special Hazards of Combustion Products: Highly toxic fumes contaning sulfur oxides may be generated along with thermal decomposition products such as ethyl ether and ethylene. Sulfuric acid may be produced in the presence of moisture. Behavior in Fire: It burns to yield highly, toxic sulfur oxides. Above 100°C, it undergoes thermal decomposition to yield ethyl ether, ethylene and sulfur oxides which may cause an explosion in closed containers or confined spaces. (USCG, 1999)
Special protective actions for fire-fighters
Use water spray, powder, foam, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. Chemical Carcinogens
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. See Chemical Dangers. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from food and feedstuffs. Dry. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens
SECTION 8: Exposure controls/personal protection
Control parameters
MAK: skin absorption (H); carcinogen category: 2; germ cell mutagen group: 2
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation, local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Liquid. Oily.
-
Colour：
Colourless but darkens with age.
-
Odour：
Peppermint odor
-
Melting point/freezing point：
-25 °C. Remarks:No data about the pressure.
-
Boiling point or initial boiling point and boiling range：
209.5 °C. Atm. press.:760 mm Hg.
-
Flammability：
Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
104 °C.
-
Auto-ignition temperature：
436 °C. Remarks:No data about pressure.
-
Decomposition temperature：
209°C
-
pH：
no data available
-
Kinematic viscosity：
dynamic viscosity (in mPa s) = 1.79. Temperature:20°C.
-
Solubility：
7 g / l (20 °C)
-
Partition coefficient n-octanol/water：
log Pow = 1.14. Remarks:No data on temperature and pH.
-
Vapour pressure：
0.212 mm Hg. Temperature:25 °C. Remarks:Corresponding to 28.26 Pa.
-
Density and/or relative density：
1.172 g/cm3. Temperature:25 °C.
-
Relative vapour density：
5.3 (vs air)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on heating. This produces flammable and toxic fumes. Reacts violently with ammonia, strong oxidants, strong bases and powdered metals. This generates fire hazard. Reacts with water and moisture. This produces sulfuric acid and ethanol.
Chemical stability
no data available
Possibility of hazardous reactions
Combustible when exposed to heat or flame.The presence of moisture in a metal container of DIETHYL SULFATE caused the formation of sulfuric acid which reacts with the metal to release hydrogen which pressurized and exploded the container [Chem. Abst. 28:2908(1934)].
Conditions to avoid
no data available
Incompatible materials
React violently with 3,8-dinitro-9-phenylphenanthridine plus water. Reaction with iron plus water forms explosive hydrogen gas.
Hazardous decomposition products
Decomposes at elevated temperature forming ethyl ether, which is more flammable than the material itself.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat - 880 mg/kg bw.
- Inhalation: no data available
- Dermal: LD50 - rabbit - 600 μL/kg.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: There is inadequate evidence for the carcinogenicity in humans of diethyl sulfate. There is sufficient evidence for the carcinogenicity of diethyl sulfate in experimental animals. Diethyl sulfate is probably carcinogenic to humans (2A). In making the overall evaluation, the Working Group took into account diethyl sulfate is a strong direct alkylating agent which ethylates DNA and that as a result, it is genotoxic in virtually all test systems examined including potent effects in somatic and germ cells of mammals exposed in vivo.
Reproductive toxicity
No information is available on the reproductive or developmental effects of diethyl sulfate in humans. After a single subcutaneous dose to pregnant rats, malignant tumors of the nervous system were reported in the offspring. (,,5)
STOT-single exposure
The substance is corrosive to the eyes, skin and respiratory tract. Inhalation may cause lung oedema. See Notes. The effects may be delayed. Medical observation is indicated.
STOT-repeated exposure
This substance is probably carcinogenic to humans. May cause heritable genetic damage to human germ cells.
Aspiration hazard
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: Cladophora crispata.
- Toxicity to microorganisms: no data available
Persistence and degradability
Diethylsulfate, present at 100 mg/l, achieved 89% of its theoretical BOD after 4 weeks using an activated sludge inoculum at 30 mg/l and the Japanese MITI test(1).
Bioaccumulative potential
Based upon the rapid rate of hydrolysis for diethylsulfate in aqueous environments(1), bioconcentration in aquatic organisms is expected to be low(SRC).
Mobility in soil
Based upon the rapid hydrolysis of diethylsulfate in aqueous environments(1), adsorption to soil and leaching are not expected to be important fate processes(SRC).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN1594 (For reference only, please check.)
IMDG: UN1594 (For reference only, please check.)
IATA: UN1594 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: DIETHYL SULPHATE (For reference only, please check.)
IMDG: DIETHYL SULPHATE (For reference only, please check.)
IATA: DIETHYL SULPHATE (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: II (For reference only, please check.)
IMDG: II (For reference only, please check.)
IATA: II (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.