Diphacinone SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Diphacinone
- CAS： 82-66-6
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 2, Oral
Specific target organ toxicity – repeated exposure, Category 1
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H300 Fatal if swallowed
H372 Causes damage to organs through prolonged or repeated exposure
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P319 Get medical help if you feel unwell.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Diphacinone
- Common names and synonyms: Diphacinone
- CAS number: 82-66-6
- EC number: 201-434-5
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Refer immediately for medical attention.
Wear protective gloves when administering first aid. Remove contaminated clothes. See Notes. Rinse and then wash skin with water and soap. Refer immediately for medical attention.
Rinse with plenty of water (remove contact lenses if easily possible).
Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention.
Most important symptoms/effects, acute and delayed
This material is extremely toxic; probable oral lethal dose in humans is 5-50 mg/kg, or between 7 drops and 1 teaspoonful for a 150-lb. person. Many medical conditions will be aggravated by this material. (EPA, 1998)
Indication of immediate medical attention and special treatment needed, if necessary
Administration of vitamin K1, SC, to anticoagulant-poisoned (diphenadione) dogs provided diagnostic information within 4 hours, when vitamin K1 and its epoxide were measured in canine sera. Twelve dogs (2 groups of 6) were given 2.5 mg of diphenadione/kg of body weight for 3 days. Dogs were treated with vitamin K1, 2.5 (n = 6) or 5 mg/kg/day (n = 6) SC for 21 days, and their responses were compared. Four nonexposed control dogs were given 5 mg of vitamin K1/kg/day. Serum concentration of vitamin K epoxide was significantly (P less than 0.02) higher in diphenadione-exposed dogs than in control dogs 1 to 4 hours after the initial vitamin K1 treatment on day 4. Vitamin K epoxide/vitamin K1 ratios were similarly higher and became more distinct. Cessation of vitamin K1 therapy on day 24 resulted in prolongation of one-stage prothrombin times in diphenadione-exposed dogs, becoming clearly evident on day 27. Serum vitamin K1 concentrations were not detectable on day 27 in diphenadione-exposed dogs, whereas serum vitamin K1 concentrations were readily detectable in control dogs. One-stage prothrombin time changes, during days 24 to 32, indicated 5 mg of vitamin K1/kg provided better protection than did 2.5 mg of vitamin K1/kg. Coagulopathy in the dogs was resolved by day 32.
SECTION 5: Firefighting measures
Suitable extinguishing media
Wear self contained breathing apparatus for fire fighting if necessary.
Specific hazards arising from the chemical
When heated to decomposition it emits acrid smoke and fumes. Sensitive to light. (EPA, 1998)
Special protective actions for fire-fighters
Use water spray, foam, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Store and dispose of according to local regulations.
Environmental precautions
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Well closed. Store in an area without drain or sewer access.
SECTION 8: Exposure controls/personal protection
Control parameters
| Component | Diphacinone | |||
|---|---|---|---|---|
| CAS No. | 82-66-6 | |||
| Limit value - Eight hours | Limit value - Short term | |||
| ppm | mg/m3 | ppm | mg/m3 | |
| Latvia | ? | 0,01 | ? | ? |
| Remarks | ||||
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear face shield or eye protection in combination with breathing protection if powder.
Protective gloves. Protective clothing.
Use closed system.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Diphacinone is an odorless pale yellow crystals. Used as a rodenticide and anticoagulant medication. (EPA, 1998)
-
Colour：
Yellow crystals
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Odour：
Odorless
-
Melting point/freezing point：
145-147°C
-
Boiling point or initial boiling point and boiling range：
528.7°C at 760 mmHg
-
Flammability：
Combustible.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
no data available
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
338°C
-
pH：
no data available
-
Kinematic viscosity：
no data available
-
Solubility：
In water, 0.3 mg/L, temp not specified
-
Partition coefficient n-octanol/water：
log Kow = 4.27
-
Vapour pressure：
1.03X10-10 mm Hg at 25 deg C
-
Density and/or relative density：
1.281(25°C)
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on heating. This produces irritating fumes.
Chemical stability
Sensitive to light
Possibility of hazardous reactions
Not flammable or combustible.DIPHACINONE is a ketone, and behaves as a weak acid. Forms water soluble alkali metal salts. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
When heated to decomposition it emits acrid smoke and fumes.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 0.3 to 2.3 mg/kg
- Inhalation: LC50 Rat inhalation 2,000 mg/cu m/4hr
- Dermal: LD50 Rat percutaneous <200 mg/kg
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance may cause effects on the blood. This may result in bleeding. The effects may be delayed. Medical observation is indicated. See Notes. Exposure could cause death.
STOT-repeated exposure
The substance may have effects on the blood. This may result in bleeding.
Aspiration hazard
A harmful concentration of airborne particles can be reached quickly when dispersed.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50; Species: /Lepomis macrochirus/ (Bluegill sunfish); Concentration: 7.6 mg/L for 96 hr /Conditions of bioassay not specified
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, flow through; Concentration: 1800 ug/L for 48 hr (95% confidence interval: 1600-2900 ug/L); Effect: intoxication, immobilization /98.7% purity
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: Radio-labeled (benzyl ring or both phenyl rings)[14C]diphacinone was metabolized with a half-life of 28.3 to 31.7 days, respectively, in sandy loam soils incubated aerobically in the dark at 25 deg C for 3.5 months. The major degradate (defined as >10% of the applied) detected in the phenyl ring labeled study was identified as diphenylglycolic acid and was present at a maximum of 24.5% of the applied at one month after application. Diphenylglycolic acid was also detected in the benzyl ring labeled study at a very low concentration (<10% of the applied). By 3.5 months post-treatment, 42.5% of the applied radioactivity was accounted for as 14CO2 in benzyl ring labeled [14C]diphacinone, and 37.3% of the applied radioactivity was accounted for as 14CO2 in the phenyl ring labeled [14C]diphacinone(1).
Bioaccumulative potential
An estimated BCF of 79 was calculated in fish for diphacinone(SRC), using a log Kow of 4.27(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).
Mobility in soil
Kd values of 5.4-1000 have been measured for diphacinone(1). The compound was immobile in columns (60 cm in length) packed with sandy loam, silt loam, sand, and loamy sand soils to a depth of 30 cm. Diphacinone was detected in the 0-6 cm layer in the columns with sandy loam and silt loam soils. In the sand soil, diphacinone was detected in the 0-6 cm layer (at 117.1% of the applied) and in the 6-12 cm layer (at <3% of the applied). Diphacinone was present in the 0-6 cm layer of the loamy sand soil at 76.1% of the applied, and was also present in the 6-12 cm, 12-18 cm, and 18-24 cm layers at 3.4%, 4.8%, and 4.4% of the applied, respectively. Diphacinone was not detected in any of the leachates collected from the four soil columns(2).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN2588 (For reference only, please check.)
IMDG: UN2588 (For reference only, please check.)
IATA: UN2588 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: PESTICIDE, SOLID, TOXIC, N.O.S. (For reference only, please check.)
IMDG: PESTICIDE, SOLID, TOXIC, N.O.S. (For reference only, please check.)
IATA: PESTICIDE, SOLID, TOXIC, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Depending on the degree of exposure, periodic medical examination is suggested.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.Do NOT take working clothes home.Isolate contaminated clothing by sealing in a bag or other container.