Chromium trioxide SDS

Oxidizing solids, Category 1

Acute toxicity - Category 3, Oral

Acute toxicity - Category 3, Dermal

Skin corrosion, Sub-category 1A

Skin sensitization, Category 1

Acute toxicity - Category 2, Inhalation

Respiratory sensitization, Category 1

Germ cell mutagenicity, Category 1B

Carcinogenicity, Category 1A

Specific target organ toxicity – repeated exposure, Category 1

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

Reproductive toxicity, Category 2

H271 May cause fire or explosion; strong oxidizer

H301 Toxic if swallowed

H311 Toxic in contact with skin

H314 Causes severe skin burns and eye damage

H317 May cause an allergic skin reaction

H330 Fatal if inhaled

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

H340 May cause genetic defects

H350 May cause cancer

H372 Causes damage to organs through prolonged or repeated exposure

H410 Very toxic to aquatic life with long lasting effects

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P220 Keep away from clothing and other combustible materials.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P283 Wear fire resistant or flame retardant clothing.

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P271 Use only outdoors or in a well-ventilated area.

P284 [In case of inadequate ventilation] wear respiratory protection.

P203 Obtain, read and follow all safety instructions before use.

P273 Avoid release to the environment.

P306+P360 IF ON CLOTHING: Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.

P371+P380+P375 In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.

P370+P378 In case of fire: Use ... to extinguish.

P301+P316 IF SWALLOWED: Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P316 Get emergency medical help immediately.

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P363 Wash contaminated clothing before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P333+P317 If skin irritation or rash occurs: Get medical help.

P362+P364 Take off contaminated clothing and wash it before reuse.

P320 Specific treatment is urgent (see ... on this label).

P342+P316 If experiencing respiratory symptoms: Get emergency medical help immediately.

P318 IF exposed or concerned, get medical advice.

P319 Get medical help if you feel unwell.

P391 Collect spillage.

P420 Store separately.

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer immediately for medical attention.

Very irritating to eyes and respiratory tract. Ingestion causes severe gastrointestinal symptoms. Contact with eyes or skin causes burns; prolonged contact produces dermatitis ("chrome sores"). (USCG, 1999)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Inorganic Acids and Related Compounds

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Behavior in Fire: Containers may explode (USCG, 1999)

NO water. In case of fire in the surroundings, use appropriate extinguishing media.

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT absorb in saw-dust or other combustible absorbents.

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT absorb in saw-dust or other combustible absorbents.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided; Methods and materials for containment and cleaning up: Sweep up and shovel. Contain spillage, and then collect with an electrically protected vacuum cleaner or by wetbrushing and place in container for disposal according to local regulations. Keep in suitable, closed containers for disposal.

NO contact with combustible substances or reducing agents. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Provision to contain effluent from fire extinguishing. Separated from combustible substances, reducing agents, bases and food and feedstuffs. Well closed. Store in an area without drain or sewer access.Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. Heat sensitive. Storage class (TRGS 510): Strongly oxidizing hazardous materials

TLV: (as Cr(VI), inhalable fraction): 0.0002 mg/m3, as TWA; 0.0005 mg/m3 as STEL; A1 (confirmed human carcinogen); (skin); (DSEN); (RSEN).EU-OEL: (as Cr): 0.1 mg/m3 as TWA.MAK: (inhalable fraction): skin absorption (H); sensitization of skin (SH); carcinogen category: 1; germ cell mutagen group: 2

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear face shield or eye protection in combination with breathing protection.

Protective gloves. Protective clothing.

Use closed system or ventilation.

no data available

250 mg/cu m (as Cr(II)). Chromium(II) compounds (as Cr)

25 mg/cu m (as Cr(III)). Chromium(III) compounds (as Cr)

15 mg/cu m (as Cr(VI)). Chromic acid and chromates

NIOSH considers chromic acid and chromates to be potential occupational carcinogens. Chromic acid and chromates

Decomposes above 250°C . This produces chromic oxide and oxygen. This increases fire hazard. The substance is a strong oxidant. It reacts violently with combustible and reducing materials. This generates fire and explosion hazard. The solution in water is a strong acid. It reacts violently with bases and is corrosive.

Stable under recommended storage conditions.

Powerful oxidizer ... contact with combustible material may cause fire.CHROMIUM TRIOXIDE is a powerful oxidizing agent. Can react violently upon contact with reducing reagents, including organic matter, leading to ignition or explosion. Dangerously reactive with acetone, alcohols, alkali metals (sodium, potassium), ammonia, arsenic, dimethylformamide, hydrogen sulfide, phosphorus, peroxyformic acid, pyridine, selenium, sulfur, and many other chemicals [Sax, 9th ed., 1996, p. 852]. Noncombustible but can accelerate the burning of combustible materials. Sufficient heat may be generated from the reaction with combustible materials to ignite the mass. Aqueous solutions corrode many metals rapidly. Often mixed with sulfuric acid to make "cleaning solution" for glass. Used cleaning solution in closed bottles may explode due to the build up of gaseous carbon dioxide arising from oxidation of organic impurities [Bryson, W. R., Chem. Brit., 1975, 11, p. 377].

no data available

Incompatible materials: Organic materials, Phosphorus, powdered metals.

Decomposes when heated to 250 deg C, liberating oxygen to support combustion.

no data available

no data available

no data available

no data available

WEIGHT OF EVIDENCE CHARACTERIZATION: Under the current guidelines (1986), Cr(VI) is classified as Group A - known human carcinogen by the inhalation route of exposure. Carcinogenicity by the oral route of exposure cannot be determined and is classified as Group D. Under the proposed guidelines (1996), Cr(VI) would be characterized as a known human carcinogen by the inhalation route of exposure on the following basis. Hexavalent chromium is known to be carcinogenic in humans by the inhalation route of exposure. Results of occupational epidemiological studies of chromium-exposed workers are consistent across investigators and study populations. Dose-response relationships have been established for chromium exposure and lung cancer. Chromium-exposed workers are exposed to both Cr(III) and Cr(VI) compounds. Because only Cr(VI) has been found to be carcinogenic in animal studies, however, it was concluded that only Cr(VI) should be classified as a human carcinogen. Animal data are consistent with the human carcinogenicity data on hexavalent chromium. Hexavalent chromium compounds are carcinogenic in animal bioassays, producing the following tumor types: intramuscular injection site tumors in rats and mice, intrapleural implant site tumors for various Cr(VI) compounds in rats, intrabronchial implantation site tumors for various Cr(VI) compounds in rats and subcutaneous injection site sarcomas in rats. In vitro data are suggestive of a potential mode of action for hexavalent chromium carcinogenesis. Hexavalent chromium carcinogenesis may result from the formation of mutagenic oxidatitive DNA lesions following intracellular reduction to the trivalent form. Cr(VI) readily passes through cell membranes and is rapidly reduced intracellularly to generate reactive Cr(V) and Cr(IV) intermediates and reactive oxygen species. A number of potentially mutagenic DNA lesions are formed during the reduction of Cr(VI). Hexavalent chromium is mutagenic in bacterial assays, yeasts and V79 cells, and Cr(VI) compounds decrease the fidelity of DNA synthesis in vitro and produce unscheduled DNA synthesis as a consequence of DNA damage. Chromate has been shown to transform both primary cells and cell lines. HUMAN CARCINOGENICITY DATA: Occupational exposure to chromium compounds has been studied in the chromate production, chromeplating and chrome pigment, ferrochromium production, gold mining, leather tanning and chrome alloy production industries. Workers in the chromate industry are exposed to both trivalent and hexavalent compounds of chromium. Epidemiological studies of chromate production plants in Japan, Great Britain, West Germany, and the United States have revealed a correlation between occupational exposure to chromium and lung cancer, but the specific form of chromium responsible for the induction of cancer was not identified ... Studies of chrome pigment workers have consistently demonstrated an association between occupational chromium exposure (primarily Cr(VI)) and lung cancer. Several studies of the chromeplating industry have demonstrated a positive relationship between cancer and exposure to chromium compounds. ANIMAL CARCINOGENICITY DATA: Animal data are consistent with the findings of human epidemiological studies of hexavalent chromium ... Chromium (VI)

no data available

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. The substance may cause effects on the kidneys and liver. This may result in tissue lesions.

Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. Repeated or prolonged inhalation may cause nasal ulceration. This may result in perforation of the nasal septum. The substance may have effects on the kidneys. This may result in kidney impairment. This substance is carcinogenic to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

A harmful concentration of airborne particles can be reached quickly when dispersed.

Biological oxygen demand (BOD): none

Using carp (Cyprinus carpio) which were exposed over a 6-week period to chromic trioxide concentrations of 1, 5, 20 and 100 ppb (measured as chromium), the chromium BCF ranged from 4.6 to 72(1). According to a classification scheme(2), this BCF range suggests the potential for bioconcentration in aquatic organisms is low to moderate(SRC).

no data available

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN1463 (For reference only, please check.)

IMDG: UN1463 (For reference only, please check.)

IATA: UN1463 (For reference only, please check.)

ADR/RID: CHROMIUM TRIOXIDE, ANHYDROUS (For reference only, please check.)

IMDG: CHROMIUM TRIOXIDE, ANHYDROUS (For reference only, please check.)

IATA: CHROMIUM TRIOXIDE, ANHYDROUS (For reference only, please check.)

ADR/RID: 5.1 (For reference only, please check.)

IMDG: 5.1 (For reference only, please check.)

IATA: 5.1 (For reference only, please check.)

ADR/RID: II (For reference only, please check.)

IMDG: II (For reference only, please check.)

IATA: II (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

no data available

no data available

Do NOT take working clothes home.Rinse contaminated clothing with plenty of water because of fire hazard.The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.Depending on the degree of exposure, periodic medical examination is suggested.