Chlorothalonil SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Chlorothalonil
- CAS： 1897-45-6
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Serious eye damage, Category 1
Skin sensitization, Category 1
Acute toxicity - Category 2, Inhalation
Specific target organ toxicity – single exposure, Category 3
Carcinogenicity, Category 2
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
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Pictogram(s)
- Signal word Danger
H318 Causes serious eye damage
H317 May cause an allergic skin reaction
H330 Fatal if inhaled
H335 May cause respiratory irritation
H351 Suspected of causing cancer
H410 Very toxic to aquatic life with long lasting effects
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P284 [In case of inadequate ventilation] wear respiratory protection.
P203 Obtain, read and follow all safety instructions before use.
P273 Avoid release to the environment.
P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P317 Get medical help.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P317 If skin irritation or rash occurs: Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316 Get emergency medical help immediately.
P320 Specific treatment is urgent (see ... on this label).
P319 Get medical help if you feel unwell.
P318 IF exposed or concerned, get medical advice.
P391 Collect spillage.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Chlorothalonil
- Common names and synonyms: Chlorothalonil
- CAS number: 1897-45-6
- EC number: 217-588-1
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.
Rinse mouth. Refer for medical attention .
Most important symptoms/effects, acute and delayed
SYMPTOMS: Symptoms of exposure to this compound include dermatitis and gastrointestinal, skin and upper respiratory tract irritation. ACUTE/CHRONIC HAZARDS: This compound is a positive animal carcinogen. When heated to decomposition it emits toxic fumes of chloride ion, NOx and cyanide ion. (NTP, 1992)
Indication of immediate medical attention and special treatment needed, if necessary
1. Wash off dermal contamination with soap and water. Remove contamination of the eyes by flushing with copious amounts of water. If irritation persists, specialized medical care should be obtained. Substituted benzenes
SECTION 5: Firefighting measures
Suitable extinguishing media
Fire Extinguishing Media: CO2, foam, dry chemical or water.
Specific hazards arising from the chemical
Literature sources indicate that this compound is nonflammable. (NTP, 1992)
Special protective actions for fire-fighters
Use water spray, foam, powder, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: chemical protection suit and protective gloves. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: chemical protection suit and protective gloves. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Solid spillage should be picked up with an industrial vacuum cleaner and disposed of in accordance with local regulations.
SECTION 7: Handling and storage
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Store in an area without drain or sewer access.Keep in cool, dry, ventilated place.
SECTION 8: Exposure controls/personal protection
Control parameters
MAK sensitization of skin (SH)
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety spectacles or eye protection in combination with breathing protection if powder.
Protective gloves. Protective clothing.
Use local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
PHYSICAL DESCRIPTION: Colorless crystals or granules or light gray powder. Melting point 250-251°C. No odor when pure; technical grade has a slightly pungent odor. A fungicide formulated as water-dispersible granules, wettable powder, or dust.
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Colour：
Colorless crystals
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Odour：
Odorless in pure form
-
Melting point/freezing point：
251°C(lit.)
-
Boiling point or initial boiling point and boiling range：
350°C(lit.)
-
Flammability：
Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
126°C(lit.)
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Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
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pH：
no data available
-
Kinematic viscosity：
no data available
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Solubility：
less than 0.1 mg/mL at 70° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
log Kow = 3.05
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Vapour pressure：
4.36E-05mmHg at 25°C
-
Density and/or relative density：
1.71g/cm3
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on heating. This produces toxic and corrosive fumes including hydrogen chloride (see ICSC 0163) and nitrogen oxides.
Chemical stability
Thermally stable at ambient temperatures. Stable to u.v. light in aqueous media and in crystalline state. Stable in acidic and moderately alkaline aqueous solutions; slow hydrolysis at pH >9.
Possibility of hazardous reactions
Chlorothalonil is non-flammable and non-explosive.CHLOROTHALONIL is stable in neutral or acidic aqueous media. May react violently with strong oxidizing acids [Farm Chemicals Handbook]. Incompatible with other oxidizing agents such as peroxides and epoxides. Breaks down slowly in basic aqueous media (half-life 38.1 days at pH 9). [Farm Chemicals Handbook].
Conditions to avoid
no data available
Incompatible materials
Cyanides
Hazardous decomposition products
May decompose at high temp to emit hydrogen chloride.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Mouse oral 3700 mg/kg
- Inhalation: LC50 Rat inhalation 310 mg/cu m/1hr
- Dermal: LD50 Rabbit (albino) percutaneous >5000 mg/kg
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Cancer Classification: Group B2 Probable Human Carcinogen
Reproductive toxicity
no data available
STOT-single exposure
The substance is severely irritating to the eyes. The substance is irritating to the respiratory tract. The substance is mildly irritating to the skin.
STOT-repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization.
Aspiration hazard
A harmful concentration of airborne particles can be reached quickly when dispersed.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50; Species: /Oncorhynchus mykiss/ (Rainbow trout); Concentration: 76 ug/L for 96 hr /Technical chlorothalonil; conditions of bioassay not specified
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea) age <24 hr; Conditions: static; Concentration: 70 ppb for 48 hr (95% confidence limit: 34.2-143 ppb); Effect: intoxication, immobilization) /96% AI formulated product
- Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (Green algae); Conditions: static; Concentration: 190 ppb/120 hr (95% confidence limit: 180-210 ppb); Effect: decreased population abundance /97.9% AI formulated product
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: In an aerobic grab sample study, 60.5% chlorothalonil (initial concentration of 38 ppm) remained in an alluvial silty loam (25 deg C and pH 6.4) after 7 days(1). At an initial concentration of 40 ppm, 67.5% (20 deg C) and 45.0% (25 deg C) chlorothalonil remained after 7 days in an alluvial silty loam (pH 6.4) held at a 60% moisture capacity(1). In the same soil held at moisture capacities of 100, 60, 40, and 20%, the amount of chlorothalonil (initial concentration of 40 ppm) remaining was determined to be 85, 22, 45, and 65%, respectively, after 7 days. Chlorothalonil biodegraded mainly through dechlorination and partly by substitution reaction yielding the biodegradation products: isophthalonitrile, mono-, di- and tri-chlorinated isophthalonitriles, 2,5,6-trichloro-4-hydroxyisophthalonitrile and 2,5,6-trichloro-4-methoxyisophthalonitrile(1). Aerobic biodegradation half-lives of chlorothalonil in four different soils were reported as 10, 10, 15 and 40 days(2). After 60 days the metabolite 2,5,6-trichloro-4-hydroxyisophtalonitrile was present at up to 32% of the initially applied amount; the metabolite 3-cyano-2,4,5,6-tetrachlorobenzamide was present at up to about 7% at both days 7 and 16 of the study. Aerobic aquatic half-lives of chlorothalonil typically range from 2 to 200 hours(2). Other reported metabolites are 1,3-dicarbamoyl-2,4,5,6-tetrachlorobenzene, 1-carbamoyl-3-cyano-4-hydroxy-2,5,6-trichlorobenzene, 2,4,6-trichloro-4-(methylthio)isophthalonitrile and pentachloronitrobenzene(3).
Bioaccumulative potential
Bioconcentration factors of 75 (edible) and 264 (whole body) were measured for chlorothalonil in bluegill sunfish(1). BCF values of 9.4 (edible) and 16 (whole body) were reported for catfish(1). Carp exposed to 3 ug/L chlorothalonil over a 6 week incubation period had reported maximum BCF values of 125 (2). A BCF of 264 was determined in bluegill (Lepomis macrochirus) exposed for 28 days(3). According to a classification scheme(4), these BCF values suggest bioconcentration in aquatic organisms can be low to high(SRC). Chlorothalonil BAFs wet weight and lipid based in zooplankton from three lakes in southern Ontario, Canada were 14-1500 and 140-190,000, respectively; samples were collected in 2003 and 2004(5).
Mobility in soil
A Koc value of 1800 has been determined based on adsorption isotherms of chlorothalonil on 3 black soils and 1 clay mineral, Na-bentonite soil(1). Other reported Koc values are 1300 to 14,000(2). Laboratory batch equilibrium studies with four soils showed chlorothalonil to possess limited mobility in silty clay loam, silt, sandy loam, and sand with calculated Koc values were 1400, 7000, 1100, and 900, respectively(3). According to a classification scheme(4), these Koc values suggest the mobility of chlorothalonil in soils will be low to immobile(SRC). The Koc of sediment from recycling ponds was 2270 to 2450(5).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN3439 (For reference only, please check.)
IMDG: UN3439 (For reference only, please check.)
IATA: UN3439 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: NITRILES, SOLID, TOXIC, N.O.S. (For reference only, please check.)
IMDG: NITRILES, SOLID, TOXIC, N.O.S. (For reference only, please check.)
IATA: NITRILES, SOLID, TOXIC, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Carrier solvents used in commercial formulations may change physical and toxicological properties.