Captafol SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Captafol
- CAS： 2425-06-1
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Skin sensitization, Category 1
Carcinogenicity, Category 1B
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
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Pictogram(s)
- Signal word Danger
H317 May cause an allergic skin reaction
H350 May cause cancer
H410 Very toxic to aquatic life with long lasting effects
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P203 Obtain, read and follow all safety instructions before use.
P273 Avoid release to the environment.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P317 If skin irritation or rash occurs: Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P318 IF exposed or concerned, get medical advice.
P391 Collect spillage.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Captafol
- Common names and synonyms: Captafol
- CAS number: 2425-06-1
- EC number: 219-363-3
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Refer for medical attention.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.
Rinse mouth. Refer for medical attention .
Most important symptoms/effects, acute and delayed
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, respiratory system; dermatitis, skin sensitization; conjunctivitis; bronchitis, wheezing; diarrhea, vomiting; liver, kidney injury; high blood pressure Target Organs: Eyes, skin, respiratory system, central nervous system, liver, kidneys, cardiovascular system (NIOSH, 2016)
Indication of immediate medical attention and special treatment needed, if necessary
1. Wash contaminated skin with soap & water. 2. Flush contaminated eyes with copious amounts of fresh water for 15 minutes. 3. Ingestions of small amounts (less than 10 mg/kg body weight) occurring less than an hour before treatment, are probably best treated by: a. Syrup of ipecac, followed by 1-2 glasses of water. B. Activated charcoal: ... after vomiting stops. C. Sodium or magnesium sulfate, as a cathartic. pesticides of low or moderate toxicity
SECTION 5: Firefighting measures
Suitable extinguishing media
Use water spray, foam, powder, carbon dioxide.
Specific hazards arising from the chemical
Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.
Special protective actions for fire-fighters
Use water spray, foam, powder, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Do NOT wash away into sewer. Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. (Extra personal protection: P3 filter respirator for toxic particles).
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Provision to contain effluent from fire extinguishing. Separated from strong bases and food and feedstuffs. Store in an area without drain or sewer access.Provision to contain effluent from fire extinguishing. Separated from strong bases, food and feedstuffs.
SECTION 8: Exposure controls/personal protection
Control parameters
TLV: 0.1 mg/m3, as TWA; (skin); (SEN); A3 (confirmed animal carcinogen with unknown relevance to humans)
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation (not if powder), local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
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Physical state：
Captafol is a white crystalline solid with a slight, but pungent odor. Mp: 162°C. Practically insoluble in water. Only slightly soluble in organic solvents. Technical captafol is a wettable light tan powder that is used as a fungicide. Inhaled dust irritates the respiratory tract. Irritates skin and damages eyes. Acute oral toxicity in humans is low. Not persistent in the environment (decomposes with a half-life of 11 days in the soil). Highly toxic to fish and other aquatic organisms.
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Colour：
White, solid
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Odour：
Slight, characteristic pungent odor.
-
Melting point/freezing point：
321° F (Decomposes) (NIOSH, 2016)
-
Boiling point or initial boiling point and boiling range：
365.7°C at 760 mmHg
-
Flammability：
Noncombustible Solid, but may be dissolved in flammable liquids.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
>100°C
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
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pH：
no data available
-
Kinematic viscosity：
no data available
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Solubility：
0.0001 % (NIOSH, 2016)
-
Partition coefficient n-octanol/water：
log Kow = 3.8
-
Vapour pressure：
1.54E-05mmHg at 25°C
-
Density and/or relative density：
1.64g/cm3
-
Relative vapour density：
(air = 1): 12
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
NIOSH considers captafol to be a potential occupational carcinogen.
Decomposes on heating. This produces toxic and corrosive fumes including hydrogen chloride (see ICSC 0163), nitrogen oxides and sulfur oxides. Attacks metals.
Chemical stability
Slowly hydrolyzed in aqueous emulsion or suspension. Rapidly hydrolyzed in acidic and alkaline media. Decomposes slowly at the melting point.
Possibility of hazardous reactions
CAPTAFOL is non-flammable but, on heating, may decompose to generate toxic fumes, such as sulfur oxides, hydrogen sulfide, hydrochloric acid, and phosgene. Stable at room temperature when dry but readily hydrolysed, especially in an alkaline environment. Captafol and mixtures containing high concentrations of captafol may react violently with alkali. Incompatible with acids, acid chlorides, acid anhydrides, and strong oxidizing agents. Sulfhydryl compounds such as glutathione and cysteine cause a rapid chemical decomposition.
Conditions to avoid
no data available
Incompatible materials
Incompatible with highly alkaline materials.
Hazardous decomposition products
When heated to decomposition it emits very toxic fumes of /hydrogen chloride, oxides of nitrogen and oxides of sulfur/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 5,000-6,200 mg ai/kg
- Inhalation: no data available
- Dermal: LD50 Rabbit percutaneous >15,400 mg/kg
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: No data were available from studies in humans. There is sufficient evidence in experimental animals for the carcinogenicity of captafol. In making the overall evaluation, the working group took into consideration the following supporting evidence: Captafol is active in a wide range of tests for genetic and related effects, including the generally insensitive in vivo assay for dominant lethal mutation. Overall evaluation: Captafol is probably carcinogenic to humans (2A).
Reproductive toxicity
no data available
STOT-single exposure
The substance is irritating to the eyes, skin and respiratory tract.
STOT-repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization and allergic conjunctivities. Repeated or prolonged inhalation may cause asthma. The substance may have effects on the liver and kidneys. This substance is probably carcinogenic to humans.
Aspiration hazard
A harmful concentration of airborne particles can be reached quickly when dispersed.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50 Rainbow trout 0.5 mg/l/96 hr /Conditions of bioassay not specified
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
In a laboratory incubation study with three kinds of soils under two moisture levels (field capacity and submergence) the biodegradation half-lives of difolatan ranged 23-55 days(1). The overall half-life of difolatan in soil is about 11 days, independent of soil type or initial concn(2). In soil, difolatan may be initially inhibitive to certain bacterial and microbial populations, but may be stimulative to certain bacterial populations(3,4). The inhibitory effect disappears in 7 days at a treatment level of 10 ppm(4). The rate of biodegradation was slowest in soil containing the highest organic carbon content(1,5).
Bioaccumulative potential
An estimated BCF of 170 was calculated for difolatan(SRC), using a log Kow of 3.80(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC), provided the compound is not altered physically or chemically after being released to the environment.
Mobility in soil
The adsorption coefficient, logKom, for difolatan based on soil organic matter has been reported as 3.08(1) and 3.09(2). Based on a relationship Kom = Koc/1.724(3), the Koc for difolatan would be 2073 and 2120, respectively. According to a classification scheme(4), these Koc values suggests that difolatan is expected to be slightly mobile in soil.
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN3077 (For reference only, please check.)
IMDG: UN3077 (For reference only, please check.)
IATA: UN3077 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 9 (For reference only, please check.)
IMDG: 9 (For reference only, please check.)
IATA: 9 (For reference only, please check.)
Packing group, if applicable
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Depending on the degree of exposure, periodic medical examination is suggested.The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.Carrier solvents used in commercial formulations may change physical and toxicological properties.Do NOT take working clothes home.