3-[3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2-benzopyrone SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： 3-[3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2-benzopyrone
- CAS： 28772-56-7
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 1, Oral
Acute toxicity - Category 1, Dermal
Acute toxicity - Category 1, Inhalation
Specific target organ toxicity – repeated exposure, Category 1
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
Reproductive toxicity, Category 1B
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H300 Fatal if swallowed
H310 Fatal in contact with skin
H330 Fatal if inhaled
H372 Causes damage to organs through prolonged or repeated exposure
H410 Very toxic to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P262 Do not get in eyes, on skin, or on clothing.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P284 [In case of inadequate ventilation] wear respiratory protection.
P273 Avoid release to the environment.
P203 Obtain, read and follow all safety instructions before use.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P320 Specific treatment is urgent (see ... on this label).
P319 Get medical help if you feel unwell.
P391 Collect spillage.
P318 IF exposed or concerned, get medical advice.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: 3-[3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2-benzopyrone
- Common names and synonyms: 3-[3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2-benzopyrone
- CAS number: 28772-56-7
- EC number: 249-205-9
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms/effects, acute and delayed
The compound is toxic by oral exposure. (EPA, 1998)
Indication of immediate medical attention and special treatment needed, if necessary
VETERINARY: Injured capillaries cannot be mended, but other measures may save the animal. Restraint & handling should be minimized. A sedative or tranquilizer may be of assistance in restraint, calming ... and reducing locomotion, thus decr tissue oxygen demand. Oxygen may be given, but manual pumping of chest is not advisable. Dyspnea may be relieved by thoracentesis. Clotting factors should be provided in form of blood transfusion (20 mL/kg, 1/2 injected quickly). Warfarin should be antagonized with slow iv injection of vitamin K1. Dogs and cats are given 5 mg/kg. This dose is repeated for 2 more days, using im route. Larger animals are given 0.5 to 1 mg/kg, and oral vitamin K1 should be admin daily for 4-6 days. The vitamin will not evoke a sudden dramatic cure; but bleeding tendency will gradually abate as clotting factors begin to be synthesized ... Menadione (vitamin K3) is not as effective as vitamin K1 ... Residual defects such as lameness or CNS signs from localized hemorrhages may disappear with gradual resorption of extravasated blood. Liver damage may be compensated by regeneration of hepatic cells. Warfarin
SECTION 5: Firefighting measures
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Specific hazards arising from the chemical
Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Fire may produce irritating or poisonous gases. Runoff from fire control water may give off poisonous gases. Runoff from fire control or dilution water may cause pollution. When heated to decomposition, it emits toxic fumes of bromine containing compounds. (EPA, 1998)
Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
SECTION 7: Handling and storage
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Keep container tightly closed in a dry and well-ventilated place.
SECTION 8: Exposure controls/personal protection
Control parameters
no data available
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Yellowish powder. Used as an anticoagulant rodenticide. (EPA, 1998)
-
Colour：
White to off-white powder
-
Odour：
Odorless
-
Melting point/freezing point：
200-210°C
-
Boiling point or initial boiling point and boiling range：
687°Cat 760 mmHg
-
Flammability：
no data available
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
369.3°C
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
no data available
-
Solubility：
In water, >1.14X10+4 at pH 5, 2.48X10-3 at pH 7, 0.180 at pH 9 (all in g/L at 20 deg C)
-
Partition coefficient n-octanol/water：
log Kow > 5 (pH 4-5, 20-25 deg C); log Kow = 3.8-4.1 (pH 6-7, 20-25 deg C); log Kow = 2.5-3.2 (pH 9-10, 20-25 deg C); log Kow = 4.3 (in purified water at 23 deg C, pH not stated)
-
Vapour pressure：
0mmHg at 25°C
-
Density and/or relative density：
1.454 g/cm3
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
No rapid reaction with air. No rapid reaction with water.
Chemical stability
Thermally stable below 200 deg C. technical, 97% pure
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
When heated to decomposition it emits toxic fumes of Br-.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 0.56-0.84 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill); Conditions: freshwater, static; Concentration: 3000 ug/L for 96 hr (95% confidence interval: 2400-3700 ug/L)
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, flow through; Concentration: 2000 ug/L for 48 hr (95% confidence interval: 1800-2600 ug/L); Effect: intoxication, immobilization /98.75% purity
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: Using OECD 301B (CO2 evolution method), bromadiolone showed 0% degradation after the 28-day incubation period which classified the compound as not readily biodegradable(1). Bromadiolone was also found to be not readily biodegradable using OECD 301D (closed bottle method) where maximum degradation reached only 31%(1). Using OECD 302D (CO2 production measured as inorganic carbon in mixed micro-organism populations), bromadiolone degradation reached a maximum of only 2% which classified the compound as not inherently biodegradable(1).
Bioaccumulative potential
Using bluegill sunfish (Lepomis macrochirus) and the OECD 305E method, bromadiolone was found to have a maximum BCF of 460 for whole fish(1). In a second study using channel catfish (Ictalurus punctatus), the whole fish BCF was 74 after 14 days(1). In both of these studies the BCF reliability was considered low due, in part, to high mortality in the exposed group of fish(1). A fish bioconcentration study with rainbow trout (Oncorhynchus mykiss) was performed, but it failed due to high mortalities of the fish(1). An estimated BCF range of 125 to >513 was calculated in fish for bromadiolone(SRC), using measured log Kow values of >5.0 at pH 4-5 and 4.07 at pH 7(1) and a regression-derived equation(2). According to a classification scheme(3), the estimated BCF values and whole fish BCF value in Bluegill sunfish suggest the potential for bioconcentration in aquatic organisms is high(SRC).
Mobility in soil
In one laboratory soil adsorption study, bromadiolone was found to have Koc values ranging from 1563-1709 (mean of 1632)(1). In another sorption study using five different soil types, bromadiolone had Koc values ranging from 3530-41600 with three of the five values above 4000(1). According to a classification scheme(2), these Koc values suggest that bromadiolone adsorption is expected to range from low mobility in soil to being immobile in soil. Results of laboratory soil column leaching and aged leaching studies indicate that bromadiolone and any potential degradation products, even if released indirectly to soil in small quantities, are not likely to move through the soil profile(1).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: no data available
IMDG: no data available
IATA: no data available
UN Proper Shipping Name
ADR/RID: no data available
IMDG: no data available
IATA: no data available
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/