Benzonitrile SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Benzonitrile
- CAS： 100-47-0
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Acute toxicity - Category 4, Dermal
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Warning
H302 Harmful if swallowed
H312 Harmful in contact with skin
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P317 Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
none
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Benzonitrile
- Common names and synonyms: Benzonitrile
- CAS number: 100-47-0
- EC number: 202-855-7
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Rest. Refer for medical attention .
Most important symptoms/effects, acute and delayed
Benzonitrile may enter the human body by ingestion, absorption through the skin, or inhalation. The earliest symptoms of cyano compound intoxication may be weakness, headaches, confusion, and occasionally nausea and vomiting. The respiratory rate and depth will usually be increased at the beginning and at later stages become slow and gasping. Blood pressure is usually normal, especially in the mild or moderately severe cases, although the pulse rate is usually more rapid than normal. (USCG, 1999)
Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Cyanide and related compounds
SECTION 5: Firefighting measures
Suitable extinguishing media
Foam, dry chemical, carbon dioxide. Water may be ineffective. Cool exposed containers with water. Wear goggles & self-contained breathing apparatus.
Specific hazards arising from the chemical
Special Hazards of Combustion Products: Toxic hydrogen cyanide and oxides of nitrogen may form in fire. (USCG, 1999)
Special protective actions for fire-fighters
Use powder, AFFF, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Remove all ignition sources. Ventilate area of spill or leak. Absorb liquids in vermiculite, dry sand, earth, or a similar material adn deposit in sealed containers. it maybe nessary to contain and dispose of this chemical as a hazardous waste.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Above 75°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from food and feedstuffs. Well closed. Keep in a well-ventilated room.Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Hygroscopic: Handle and store under inert gas.
SECTION 8: Exposure controls/personal protection
Control parameters
no data available
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety goggles or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation, local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Liquid.
-
Colour：
Colourless.
-
Odour：
Odor of volatile oil of almond
-
Melting point/freezing point：
-12.75 °C. Remarks:Melting Point.;-12.8 °C. Remarks:Freezing point.;-12.75°C. Remarks:Freezing point.
-
Boiling point or initial boiling point and boiling range：
190.7 °C. Remarks:No further details.
-
Flammability：
Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
66 °C.
-
Auto-ignition temperature：
615 °C.
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
kinematic viscosity (in mm2/s) = 1.054. Temperature:37.78°C.
-
Solubility：
1 to 5 mg/mL at 73° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
log Pow = 1.5. Temperature:20 °C. Remarks:PH of the water phases and the saturated buffer solutions.;Pow = 35. Temperature:20 °C. Remarks:PH of the water phases and the saturated buffer solutions.
-
Vapour pressure：
Ca. 0.18 hPa. Temperature:Ca. 0 °C.;Ca. 0.38 hPa. Temperature:Ca. 10 °C.;Ca. 0.78 hPa. Temperature:Ca. 20 °C.
-
Density and/or relative density：
1.01 g/L.
-
Relative vapour density：
3.6 (NTP, 1992) (Relative to Air)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on heating and on burning. This produces toxic fumes including hydrogen cyanide and nitrogen oxides. Reacts violently with strong acids. This produces highly toxic hydrogen cyanide. Attacks some plastics.
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
Combustible but burns with difficulty.The cyano group can be readily hydrolyzed in the presence of mineral acids to produce stable, moderately toxic benzoic acid . When heated to decomposition, it emits highly toxic fumes of nitrogen oxides and hydrogen cyanide [Sax, 9th ed., 1996, p. 353].
Conditions to avoid
no data available
Incompatible materials
Strong acids which can liberate hydrogen cyanide. Forms explosive mixture with air.
Hazardous decomposition products
When heated to decomp it emits toxic fumes of /cyanides and nitrogen oxides/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male/female) - 1 000.
- Inhalation: LC0 - rat (male/female) - 0.8 mg/L air.
- Dermal: LD50 - rabbit (male/female) - 1 400 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the cellular respiration. This may result in cyanosis. The effects may be delayed. Medical observation is indicated.
STOT-repeated exposure
no data available
Aspiration hazard
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: TLm - Pimephales promelas - 116 mg/L - 24 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age < or =24 hr; Conditions: freshwater, static, 20-22 deg C, pH 7.6-7.7; Concentration: 200000 ug/L for 24 hr; Effect: intoxication, immobilization /formulation
- Toxicity to algae: Scenedesmus quadricauda - 75 mg/L.
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: Benzonitrile , present at 100 mg/L, reached 63.4% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Other screening studies give similar results (63.4-80.8%) and benzonitrile is confirmed to be biodegradable according to the standard test of the Japanese Ministry of Industry and Trade (MITI) that employs a mixed inoculum obtained from freshwater, soil, and sludge(2-4). The theoretical oxygen demand (ThOD) for benzonitrile in Ohio River Water from Cincinnati and/or aged sewage sludge were 0, 60, 90% and/or 0, 40, 80% after 2, 5, and 12 days, respectively(5). The BOD for benzonitrile in a bench-scale activated sludge unit was measured to be 93-98%(6). The BOD for benzonitrile in river water, present at 50 ppm, was 7%(7). Benzonitrile achieved 100% degradation after 280 minutes in a phosphate buffer solution in the soil and after 500 minutes in a soil slurry(8). Benzonitrile also achieved 20% and 44% in ash and ash-amended soil slurries at 2000 minutes, respectively(8). Benzonitrile achieved 88% degradation after 8, 10, and 12.5 hours in char-amended soil, soil and washed-char-amended soil slurries(9).
Bioaccumulative potential
An estimated BCF of 5 was calculated in fish for benzonitrile(SRC), using a measured log Kow of 1.56(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
The Koc of benzonitrile is estimated as 150(SRC), using a log Kow of 1.56(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that benzonitrile is expected to have moderate mobility in soil(SRC).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN2224 (For reference only, please check.)
IMDG: UN2224 (For reference only, please check.)
IATA: UN2224 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: BENZONITRILE (For reference only, please check.)
IMDG: BENZONITRILE (For reference only, please check.)
IATA: BENZONITRILE (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: II (For reference only, please check.)
IMDG: II (For reference only, please check.)
IATA: II (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.