1-aminopropan-2-ol SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： 1-aminopropan-2-ol
- CAS： 78-96-6
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Skin corrosion, Sub-category 1B
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H314 Causes severe skin burns and eye damage
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316 Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: 1-aminopropan-2-ol
- Common names and synonyms: 1-aminopropan-2-ol
- CAS number: 78-96-6
- EC number: 201-162-7
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.
First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention .
Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.
Rinse mouth. Give nothing to drink. Do NOT induce vomiting. Refer immediately for medical attention.
Most important symptoms/effects, acute and delayed
Vapor irritates eyes and nose. Liquid causes local injury to mouth, throat, digestive tract, skin, and eyes. (USCG, 1999)
Indication of immediate medical attention and special treatment needed, if necessary
no data available
SECTION 5: Firefighting measures
Suitable extinguishing media
Alcohol foam
Specific hazards arising from the chemical
Special Hazards of Combustion Products: Irritating vapors generated when heated. (USCG, 1999)
Special protective actions for fire-fighters
Use water spray, powder, alcohol-resistant foam, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Above 77°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from strong oxidants and food and feedstuffs. See Chemical Dangers. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access.
SECTION 8: Exposure controls/personal protection
Control parameters
| Component | 1-aminopropan-2-ol | |||
|---|---|---|---|---|
| CAS No. | 78-96-6 | |||
| Limit value - Eight hours | Limit value - Short term | |||
| ppm | mg/m3 | ppm | mg/m3 | |
| Germany (AGS) | 2 (1) | 5,8 (1) | 4 (1)(2) | 11,6 (1)(2) |
| Remarks | ||||
| Germany (AGS) | (1) Inhalable aerosol and vapour (2) 15 minutes reference period | |||
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation, local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Liquid.
-
Colour：
Colurless.
-
Odour：
SLIGHT AMMONIA ODOR
-
Melting point/freezing point：
1 °C.
-
Boiling point or initial boiling point and boiling range：
159.73 °C. Atm. press.:1 013 hPa.
-
Flammability：
Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
80 °C. Atm. press.:1 013 hPa.
-
Auto-ignition temperature：
365 °C. Atm. press.:1 013 hPa.
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
dynamic viscosity (in mPa s) = 30.2. Temperature:20°C.
-
Solubility：
greater than or equal to 100 mg/mL at 67.6° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
log Pow = -0.93. Temperature:23 °C.
-
Vapour pressure：
0.63 hPa. Temperature:25 °C.
-
Density and/or relative density：
0.96. Temperature:20 °C.
-
Relative vapour density：
2.6 (NTP, 1992) (Relative to Air)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
On combustion, forms nitrogen oxides. Reacts violently with strong oxidants, cellulose nitrate, nitric acid and aldehydes.
Chemical stability
no data available
Possibility of hazardous reactions
MONOISOPROPANOLAMINE is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
no data available
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male/female) - 2 813 mg/kg bw. Remarks:The LD50 was calculated from the original ml/kg values by using the density of 0.97 g/cm3.
- Inhalation: RD50 (calculated) - mouse (male) - ca. 440 mg/m3 air.
- Dermal: LD50 - rabbit - 1 851 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. Medical observation is indicated. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.
STOT-repeated exposure
Repeated or prolonged contact with skin may cause dermatitis.
Aspiration hazard
No indication can be given whether a harmful concentration in the air will be reached.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50 - Leuciscus idus - 215 - 464 mg/L - 96 h. Remarks:Not neutralized.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 108.82 mg/L - 48 h. Remarks:Not neutralized.
- Toxicity to algae: EC50 - Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) - 32.7 mg/L - 72 h.
- Toxicity to microorganisms: EC50 - activated sludge - > 261 mg/L - 30 min.
Persistence and degradability
A 5-day theoretical BOD of 4% was observed for 1-amino-2-propanol using a non-acclimated sewage inocula and a standard BOD dilution method(1); adaptation of the sewage inocula resulted in a 5-day theoretical BOD of 43%(1). Using a sewage inocula and a BOD dilution method, 5-day, 10-day, 15-day and 20-day theoretical BODs of 5.1, 34.0, 43.4 and 46.0% were measured respectively for 1-amino-2-propanol(2). In anaerobic serum bottle degradation studies, 1-amino-2-propanol exhibited a lag period of 9 days followed by a removal rate of 22 mg/l/day(3); during the observation period, 65% of initial 1-amino-2-propanol was removed compared to 100% removal for 1-propanol(3). 1-Amino-2-propanol is considered to be amenable to anaerobic biotechnology for industrial wastewater treatment(4).
Bioaccumulative potential
Based upon an experimental log Kow of - 0.96(1), the BCF for 1-amino-2-propanol can be estimated to be 0.11 from a regression-derived equation(2,SRC). This BCF value suggests that 1-amino-2-propanol will not bioconcentrate significantly in aquatic organisms(SRC).
Mobility in soil
Based upon an experimental log Kow of -0.96(1), the Koc for 1-amino-2-propanol can be estimated to be 7.1 from a regression-derived equation(2,SRC). This BCF value suggests that 1-amino-2-propanol has very high soil mobility(3).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN2735 (For reference only, please check.)
IMDG: UN2735 (For reference only, please check.)
IATA: UN2735 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: AMINES, LIQUID, CORROSIVE, N.O.S. or POLYAMINES, LIQUID, CORROSIVE, N.O.S. (For reference only, please check.)
IMDG: AMINES, LIQUID, CORROSIVE, N.O.S. or POLYAMINES, LIQUID, CORROSIVE, N.O.S. (For reference only, please check.)
IATA: AMINES, LIQUID, CORROSIVE, N.O.S. or POLYAMINES, LIQUID, CORROSIVE, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 8 (For reference only, please check.)
IMDG: 8 (For reference only, please check.)
IATA: 8 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/