Cicloheximide SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Cicloheximide
- CAS： 66-81-9
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 2, Oral
Germ cell mutagenicity, Category 2
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
Reproductive toxicity, Category 1B
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H300 Fatal if swallowed
H341 Suspected of causing genetic defects
H411 Toxic to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P273 Avoid release to the environment.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
P391 Collect spillage.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Cicloheximide
- Common names and synonyms: Cicloheximide
- CAS number: 66-81-9
- EC number: 200-636-0
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Rest.
Most important symptoms/effects, acute and delayed
This material is extremely toxic; the probable oral lethal dose in humans is 5-50 mg/kg, or 7 drops to 1 teaspoonful for a 150-lb. person. (EPA, 1998)
Indication of immediate medical attention and special treatment needed, if necessary
no data available
SECTION 5: Firefighting measures
Suitable extinguishing media
Non-Specific -- Fungicides, Poison B Solid) Avoid breathing dusts and fumes from burning material. Keep upwind. Wear self-contained breathing apparatus. Avoid bodily contact with the material. Wear full protective clothing. (Non-Specific -- Fungicides, Poison B Solid) Use agent suitable for surrounding fire. Use alcohol foam, carbon dioxide, or dry chemical. Use water in flooding quantities as fog. (EPA, 1998)
Specific hazards arising from the chemical
When exposed to heat, it emits toxic fumes, including nitrogen oxides. (EPA, 1998)
Special protective actions for fire-fighters
In case of fire in the surroundings, use appropriate extinguishing media.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Evacuate danger area! Consult an expert! Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT wash away into sewer. Sweep spilled substance into covered sealable containers. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Evacuate danger area! Consult an expert! Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT wash away into sewer. Sweep spilled substance into covered sealable containers. Carefully collect remainder. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
In situ amelioration: Seek professional environmental engineering assistance through EPA's Environmental Response Team (ERT), Edison, NJ, 24-hour phone number (201) 321-6660. Contain and isolate spill to limit spread. Construct clay/bentonite swale to divert uncontaminated portion of the watershed around contaminated portion. Isolation procedures include construction of bentonite, polyethylene-lined dams, interceptor trenches, or impoundments. ... Conduct bench-scale and pilot-scale tests prior to decontamination program implementation. Solids must be removed in settling basins. Treatment alternatives for diluted contaminated waters include powdered activated carbon sorption, granular activated carbon filtration, and impoundment in a lined pit with leachate collection system and domed cover.
SECTION 7: Handling and storage
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from food and feedstuffs. Well closed. Keep in a well-ventilated room.
SECTION 8: Exposure controls/personal protection
Control parameters
no data available
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety spectacles.
Protective gloves.
Use local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Cycloheximide is a colorless crystals. Used as a fungicide and as a anticancer drug. (EPA, 1998)
-
Colour：
Plates from amyl acetate, water or 30% methanol
-
Odour：
no data available
-
Melting point/freezing point：
107-114°C
-
Boiling point or initial boiling point and boiling range：
491.8°C at 760 mmHg
-
Flammability：
Gives off irritating or toxic fumes (or gases) in a fire.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
251.2°C
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
no data available
-
Solubility：
10 to 50 mg/mL at 68° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
log Kow = 0.55
-
Vapour pressure：
no data available
-
Density and/or relative density：
1.136 g/cm3
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on heating. This produces toxic and corrosive fumes including nitrogen oxides.
Chemical stability
Relatively heat and acid stable; rapidly inactivated at room temp by dil alkali with formation of a volatile, fragrant ketone, 2,4-dimethylcyclohexanone
Possibility of hazardous reactions
CYCLOHEXIMIDE is an imide. This chemical is incompatible with strong oxidizing agents, acid chlorides and acid anhydrides. It decomposes rapidly in alkali at room temperature. (NTP, 1992)
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 2 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is irritating to the eyes and skin. Exposure could cause death. See Notes.
STOT-repeated exposure
no data available
Aspiration hazard
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
Cycloheximide, present at 100 mg/l, reached 1% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/l and the Japanese MITI test(1).
Bioaccumulative potential
At a concentration of 50 ug/l, cycloheximide had a BCF of <0.3 while at 5 ug/l it had a BCF of <2.8 in orange-red killi fish(1). According to a classification scheme(2), these BCF values suggest bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
The Koc of cycloheximide is estimated as 47(SRC), using a log Kow of 0.55(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that cycloheximide is expected to have very high mobility in soil. Cycloheximide was classified as a relatively mobile compound in soil based upon a measured Rf value of 0.89 as determined by soil thin-layer chromatography (TLC) in Hagerstown silty clay loam soil(4).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN2903 (For reference only, please check.)
IMDG: UN2903 (For reference only, please check.)
IATA: UN2903 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: PESTICIDE, LIQUID, TOXIC, FLAMMABLE, N.O.S., flash point not less than 23 °C (For reference only, please check.)
IMDG: PESTICIDE, LIQUID, TOXIC, FLAMMABLE, N.O.S., flash point not less than 23 °C (For reference only, please check.)
IATA: PESTICIDE, LIQUID, TOXIC, FLAMMABLE, N.O.S., flash point not less than 23 °C (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Depending on the degree of exposure, periodic medical examination is suggested.Insufficient data are available on the effect of this substance on human health, therefore utmost care must be taken.Animal studies have indicated that the substance may be very toxic by ingestion.