Acetamide SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Acetamide
- CAS： 60-35-5
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Carcinogenicity, Category 2
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Warning
H351 Suspected of causing cancer
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P318 IF exposed or concerned, get medical advice.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Acetamide
- Common names and synonyms: Acetamide
- CAS number: 60-35-5
- EC number: 200-473-5
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest.
Remove contaminated clothes. Rinse skin with plenty of water or shower.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Refer for medical attention .
Most important symptoms/effects, acute and delayed
SYMPTOMS: Exposure to this compound may cause irritation to the eyes, skin and mucous membranes. ACUTE/CHRONIC HAZARDS: This chemical may cause skin and eye irritation and corneal damage. (NTP, 1992)
Indication of immediate medical attention and special treatment needed, if necessary
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 min, occasionally lifting upper and lower lids. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. When this chemical has been swallowed, get medical attention. ... If this chemical has been inhaled, remove from exposure and transfer promptly to a medical facility.
SECTION 5: Firefighting measures
Suitable extinguishing media
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
Specific hazards arising from the chemical
The flash point of this chemical has not been determined, but it is probably combustible. (NTP, 1992)
Special protective actions for fire-fighters
Use water spray, powder.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: P2 filter respirator for harmful particles. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: P2 filter respirator for harmful particles. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Dry. Well closed.Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive.
SECTION 8: Exposure controls/personal protection
Control parameters
MAK: carcinogen category: 3B.TLV: 1 ppm as TWA; A3 (confirmed animal carcinogen with unknown relevance to humans)
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety spectacles.
Protective gloves. Protective clothing.
Use local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Solid. Crystalline.
-
Colour：
Colourless.
-
Odour：
Odorless when pure, but frequently has a mousy odor
-
Melting point/freezing point：
80.16 °C. Atm. press.:1 013 hPa.
-
Boiling point or initial boiling point and boiling range：
222 °C. Atm. press.:1 013 hPa.
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Flammability：
Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
-
Lower and upper explosion limit/flammability limit：
no data available
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Flash point：
43°C(lit.)
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
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pH：
no data available
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Kinematic viscosity：
2.182 centipose (91.1 deg C); 1.461 centipose (111.8 deg C); 1.056 centipose (131.7 deg C)
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Solubility：
Very soluble (greater than or equal to 100 mg/mL at 72° F) (NTP, 1992)
-
Partition coefficient n-octanol/water：
log Pow = < 0.3. Temperature:25 °C.
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Vapour pressure：
1.61 Pa. Temperature:20 °C.;2.42 Pa. Temperature:25 °C.
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Density and/or relative density：
1.159 g/cm3. Temperature:20 °C.
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on burning. This produces toxic fumes including nitrogen oxides. Reacts with acids and strong oxidants.
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
This substance is a combustible solid.ACETAMIDE may react with azo and diazo compounds to generate toxic gases. May form flammable gases with strong reducing agents. Reacts as a weak bases (weaker than water). Mixing with dehydrating agents such as P2O5 or SOCl2 generates acetonitrile Burns to give toxic mixed oxides of nitrogen (NOx).
Conditions to avoid
no data available
Incompatible materials
Incompatible materials: Strong oxidizing agents, strong acids, strong bases, strong reducing agents.
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions - Carbon oxides, nitrogen oxides (NOx).
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male) - 12.9 g/kg.
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Cancer classification: Group C - possible human carcinogen.
Reproductive toxicity
No information is available on the reproductive or developmental effects of acetamide in humans. Animal studies have not reported any significant developmental effects from exposure to acetamide.
STOT-single exposure
The substance is irritating to the eyes and skin.
STOT-repeated exposure
This substance is possibly carcinogenic to humans.
Aspiration hazard
Evaporation at 20°C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: LC50 - Daphnia magna - > 10 000 mg/L - 24 h.
- Toxicity to algae: toxicity threshold - Scenedesmus quadricauda - > 10 000 mg/L - 8 d.
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: Using OECD Guideline 301D (Ready Biodegradability: Closed Bottle Test) and a domestic sewage inoculum, acetamide at an initial concentration of 6.08 mg/L reached 69% of theoretical degradation in a 10-day window which classified the compound as readily biodegradable(1). Acetamide, present at 100 mg/L, reached 69% of its theoretical BOD in 3 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test which classified the compound as readily biodegradable(2). In screening tests in which acetamide was incubated with activated sludge from 3 sewage treatment plants, 29.6-45.7% of theoretical BOD was utilized in 24 hr(3). A study reported acetamide to be easily biodegraded in a screening test using a sewage inoculum with 44% of theoretical BOD utilized in 3 days including a 10 hr lag period(4).
Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for acetamide(SRC), using a log Kow of -1.26(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
An experimental Koc of 5 has been reported for acetamide(1). According to a classification scheme(2), this Koc value suggests that acetamide is expected to have very high mobility in soil.
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Packing group, if applicable
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/