Diarsenic pentaoxide SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Diarsenic pentaoxide
- CAS： 1303-28-2
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 3, Inhalation
Carcinogenicity, Category 1A
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
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Pictogram(s)
- Signal word Danger
H301 Toxic if swallowed
H331 Toxic if inhaled
H350 May cause cancer
H410 Very toxic to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P273 Avoid release to the environment.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316 Get emergency medical help immediately.
P318 IF exposed or concerned, get medical advice.
P391 Collect spillage.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Diarsenic pentaoxide
- Common names and synonyms: Diarsenic pentaoxide
- CAS number: 1303-28-2
- EC number: 215-116-9
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.
Rinse mouth. Refer immediately for medical attention. See Notes.
Most important symptoms/effects, acute and delayed
This material is extremely toxic; the probable oral lethal dose for humans is 5-50 mg/kg, or between 7 drops and 1 teaspoonful for a 150-lb. person. It is irritating to eyes, nose, and throat. Chronic exposure may cause nerve damage to the extremities, alter cellular composition of the blood, and cause structural changes in blood components. There is sufficient evidence that inorganic arsenic compounds are skin and lung carcinogens in humans. (EPA, 1998)
Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Remove patient from contact with the material. Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Arsenic and related compounds
SECTION 5: Firefighting measures
Suitable extinguishing media
If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, dry chemical, or carbon dioxide.
Specific hazards arising from the chemical
Fire may produce irritating or poisonous gases. Reacts with metal and may give off toxic arsine gas. Hazardous polymerization may not occur. (EPA, 1998)
Special protective actions for fire-fighters
In case of fire in the surroundings, use appropriate extinguishing media.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Store and dispose of according to local regulations.
Environmental precautions
Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a POTW is acceptable only after review by the governing authority. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must meet Hazardous Material Criteria for disposal.
SECTION 7: Handling and storage
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from strong bases, reducing agents and food and feedstuffs. Dry. Well closed.Store in tightly-closed containers in a cool, well-ventilated area away from metals, acids and other incompatible materials.
SECTION 8: Exposure controls/personal protection
Control parameters
TLV: 0.01 mg/m3, as TWA; A1 (confirmed human carcinogen); BEI issued.MAK: skin absorption (H); carcinogen category: 1; germ cell mutagen group: 3A
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear face shield or eye protection in combination with breathing protection if powder.
Protective gloves. Protective clothing.
Use closed system and breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Arsenic pentoxide is a white crystalline solid. Noncombustible. Corrosive to metals in the presence of moisture. Toxic by ingestion.
-
Colour：
White amorphous powder
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Odour：
no data available
-
Melting point/freezing point：
315°C
-
Boiling point or initial boiling point and boiling range：
no data available
-
Flammability：
Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
Not flammable (EPA, 1998)
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
315°C
-
pH：
no data available
-
Kinematic viscosity：
no data available
-
Solubility：
In water, 65.8 g/100 g at 20 deg C
-
Partition coefficient n-octanol/water：
no data available
-
Vapour pressure：
no data available
-
Density and/or relative density：
4.32
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
5 mg/cu m (as As); NIOSH considers arsenic (inorganic compounds, as As) to be a potential occupational carcinogen. Arsenic (inorganic compounds, as As)
Decomposes above 300°C . This produces toxic fumes (arsenic trioxide - see ICSC 0378) and oxygen. The solution in water is a weak acid. Reacts violently with bromine pentafluoride. This generates fire and explosion hazard. Reacts with reducing agents. This produces very toxic gas (arsine - see ICSC 0222). Attacks many metals in the presence of water or moisture.
Arsenic pentoxide reacts violently with bromine pentafluoride and reducing agents.Arsenic pentoxide is an oxidizer.Arsenic pentoxide is a weak acid in water.Arsenic pentoxide attacks many metals in the presence of water or moisture.
Chemical stability
Gradually deliquesces on exposure to air
Possibility of hazardous reactions
Not combustible, but if involved in a fire decomposes to produce fumes of arsenic.ARSENIC PENTOXIDE is an oxidizing acid. Oxidizing acids are generally soluble in water with the release of hydrogen ions. The resulting solutions have pH's of less than 7.0. Materials in this group react with chemical bases (for example: amines and inorganic hydroxides) to form salts. These neutralization reactions occur as the base accepts hydrogen ions that the acid donates. Neutralizations can generate dangerously large amounts of heat in small spaces. The dissolution of acids in water or the dilution of their concentrated solutions with water may generate significant heat. The addition of water acids often generates sufficient heat in the small region of mixing to boil some of the water explosively. The resulting "bumping" spatters acid widely. These materials have significant ability as oxidizing agents. but that ability varies (for example, from high for nitric acid to low for sulfuric acid and most sulfonic acids). They can react with active metals, including iron and aluminum, and also many less active metals, to dissolve the metal and liberate hydrogen and/or toxic gases. Like other acids, materials in this group can initiate polymerization in certain classes of organic compounds. Their reactions with cyanide salts and compounds release gaseous hydrogen cyanide. Flammable and/or toxic gases are also often generated by their reactions with dithiocarbamates, isocyanates, mercaptans, nitrides, nitriles, sulfides, and weak or strong reducing agents. Additional gas-generating reactions occur with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), and even carbonates: the carbon dioxide gas from the last is nontoxic but the heat and spattering from the reaction can be troublesome. Acids often catalyze (increase the rate of) chemical reactions.
Conditions to avoid
no data available
Incompatible materials
With bromine pentafluoride: Contact with arsenic pentoxide at ambient or slightly elevated temperatures is violent, ignition often occurring.
Hazardous decomposition products
Arsenic pentoxide is thermally unstable & begins to decompose near the melting point, about 300 deg C. The vapor obtained is /completely/ dissociated into oxygen & arsenic trioxide.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 8 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Classification of carcinogenicity: 1) evidence in humans: sufficient; 2) evidence in animals: limited. Overall summary evaluation of carcinogenic risk to humans is Group 1: Carcinogenic to humans. NOTE: This evaluation applies to the group of chemicals as a whole and not necessarily to all individual chemicals within the group. Arsenic and arsenic compounds
Reproductive toxicity
no data available
STOT-single exposure
The substance and the aerosol are irritating to the eyes, respiratory tract and skin. The substance may cause effects on the blood, cardiovascular system, liver and central nervous system. The effects may be delayed. See Notes. Medical observation is indicated.
STOT-repeated exposure
The substance may have effects on the skin (hyperkeratosis), cardiovascular system, bone marrow (hematopoietic changes), central nervous system, peripheral nervous system, kidneys and liver. This substance is carcinogenic to humans. Causes toxicity to human reproduction or development.
Aspiration hazard
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50; Species: Oncorhynchus mykiss (Rainbow trout); Conditions: freshwater, static, 20 deg C, hardness 285 mg/L CaCO3; Concentration: 28000 ug/L for 96 hr
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
no data available
Bioaccumulative potential
Stagnicola emarginata (snail) exposed to /SRP: a solution of/ arsenic pentoxide for 28 days exhibited a bioaccumulation factor of 3; Helisoma campanualtum (snail) exposed to arsenic pentoxide for 28 days exhibited a bioaccumulation factor of 6; Daphnia magna (cladoceran) exposed to arsenic acid for 4 days exhibited a bioaccumulation factor of 21; Gammarus pseudolimnaeus (amphipod) exposed to arsenic pentoxide for 28 days exhibited a bioaccumulation factor of 0; Pteronarcys dorsata (stonefly) exposed to arsenic pentoxide for 28 days exhibited a bioaccumulation factor of 7; Salmo gairdneri (rainbow trout) exposed to arsenic pentoxide for 28 days exhibited a bioaccumulation factor of 0; Pimephales (fathead minnow) exposed to arsenic pentoxide for 30 days exhibited a bioaccumulation factor of 3.
Mobility in soil
no data available
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN1559 (For reference only, please check.)
IMDG: UN1559 (For reference only, please check.)
IATA: UN1559 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: ARSENIC PENTOXIDE (For reference only, please check.)
IMDG: ARSENIC PENTOXIDE (For reference only, please check.)
IATA: ARSENIC PENTOXIDE (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: II (For reference only, please check.)
IMDG: II (For reference only, please check.)
IATA: II (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Do NOT take working clothes home.Depending on the degree of exposure, periodic medical examination is suggested.The symptoms of acute poisoning do not become manifest until 0.5 to several hours.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.The recommendations on this Card also apply to inorganic pentavalent arsenic compounds (arsenates).