4-nitrophenol SDS

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Dermal

Acute toxicity - Category 4, Inhalation

Specific target organ toxicity – repeated exposure, Category 2

H302 Harmful if swallowed

H312 Harmful in contact with skin

H332 Harmful if inhaled

H373 May cause damage to organs through prolonged or repeated exposure

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P301+P317 IF SWALLOWED: Get medical help.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P317 Get medical help.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P319 Get medical help if you feel unwell.

none

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Rest. Refer for medical attention .

Inhalation or ingestion causes headache, drowsiness, nausea, and blue color in lips, ears, and fingernails (cyanosis). Contact with eyes or skin causes irritation; can be absorbed through skin to give same symptoms as for inhalation. (USCG, 1999)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Dinitrophenol and Related Compounds

Use water spray, dry chemical, foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Fight fire from protected location or maximum possible distance.

Special Hazards of Combustion Products: Toxic oxides of nitrogen and fumes of unburned material may form in fires. Behavior in Fire: Decomposes violently at 279°C and will burn even in absence of air. (USCG, 1999)

Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Spill or leak procedures: Shovel into suitable dry container.

NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from combustible substances, reducing agents and food and feedstuffs. Well closed.... KEEP ALL FLAMMABLES AWAY FROM AREA WHERE OXIDIZING AGENTS ARE STORED. ... AREA ... KEPT COOL & VENTILATED, & SHOULD BE FIREPROOFED.

no data available

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear safety spectacles, face shield or eye protection in combination with breathing protection.

Protective gloves. Protective clothing.

Use local exhaust or breathing protection.

no data available

May explode on heating. Decomposes on heating. This produces toxic fumes including nitrogen oxides. Mixtures with potassium hydroxide are explosive.

no data available

Will burn even in absence of air.Dust explosion possible if in powder or granular form, mixed with air.4-NITROPHENOL is a slightly yellow, crystalline material, moderately toxic. Mixtures with diethyl phosphite may explode when heated. Decomposes exothermally, emits toxic fumes of oxides of nitrogen [Lewis, 3rd ed., 1993, p. 941]. Decomposes violently at 279°C and will burn even in absence of air (USCG, 1999). Solid mixtures of the nitrophenol and potassium hydroxide (1:1.5 mol) readily deflagrate [Bretherick, 5th Ed., 1995].

no data available

Mixtures with diethyl phosphite may explode when heated.

Decomposes violently @ 279 deg c ...

no data available

no data available

no data available

no data available

Cancer Classification: Group D Not Classifiable as to Human Carcinogenicity

No information is available on the reproductive or developmental effects of 4-nitrophenol in humans. One animal study reported no histological alterations in the testes and epididymides in mice exposed to 4-nitrophenol by inhalation, while in another study no changes were observed in the reproductive index of pregnant mice given 4-nitrophenol by gavage (placing the chemical experimentally in the stomach).

The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.

Repeated or prolonged contact may cause skin sensitization.

Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.

PURE CULTURE: Pseudomonas strains capable of mineralizing 2,4-dichlorophenol and p-nitrophenol (PNP) in culture media were isolated from soil. A Pseudomonas able to mineralize 5.0 ug p-nitrophenol/mL in culture did not mineralize the compound in sterile or nonsterile lake water. The bacterium destroyed p-nitrophenol in sterile sewage and enhanced p-nitrophenol mineralization in nonsterile sewage. When added to the surface of sterile soil, the bacterium mineralized little of the p-nitrophenol present at 5.0 ug/g, but it was active if mixed well with the sterile soil.[Goldstein RM et al; Appl Environ Microbiol 50 (4): 977-83 (1985)] Full text: PMC291779

BCF values of 2.5 to 7.8 were measured for carp (Carprinus carpio) exposed to 0.02 ppm and 0.2 ppm 4-nitrophenol over a 6-8 week incubation period(1). The BCF value of 4-nitrophenol was reported as 79 in fathead minnows(2) and 58 in golden orfe(3). According to a classification scheme(4), these BCF values suggest bioconcentration in aquatic organisms is low to moderate.

The sorption of benzoic acid, nitrobenzene, 4-nitrophenol, 2,4-dichlorophenoxyacetic acid, and naphthalene was determined for 10 Danish soils in laboratory studies(1); measured equilibrium isotherms were of nonlinear Freundlich type for nearly all combinations of soil test compounds(1); adsorption was significantly correlated with the organic carbon content of the soils tested(1); Koc values in the 10 soils ranged from 56 to 530 with an average Koc 210(1); no significant correlations with pH and cation exchange capacity were observed(1). The Koc of 4-nitrophenol was reported as 55 in Brookston clay loam(2) and a log Koc of 1.7 was reported in a second study(3). The increasing content of copper in two Chinese soils was shown to limit 4-nitrophenol adsorption(4). In sorption studies using peat, 4-nitrophenol had measured Koc values of 96 (when 4-nitrophenol was in the neutral state) and 16 (when 4-nitrophenol existed as anionic species)(5). Using a reference soil from Germany, 4-nitrophenol had Koc value of 148 in a soil column leaching test(6). A Koc of 26 was measured in one sediment sample from China(7). A median literature Koc value of 234 (log Koc = 2.37) has been reported for 4-nitrophenol which can be used to develop QSAR estimations(8). According to a classification scheme(9), a median Koc value of 234 suggests that 4-nitrophenol is expected to have moderate mobility in soil. However, the experimental Koc range extends from 16 to over 500 suggesting a range of very high mobility to low mobility(SRC). The pKa of 4-nitropehnol is 7.15(10), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(11).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN1663 (For reference only, please check.)

IMDG: UN1663 (For reference only, please check.)

IATA: UN1663 (For reference only, please check.)

ADR/RID: NITROPHENOLS (o-, m-, p-) (For reference only, please check.)

IMDG: NITROPHENOLS (o-, m-, p-) (For reference only, please check.)

IATA: NITROPHENOLS (o-, m-, p-) (For reference only, please check.)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

ADR/RID: III (For reference only, please check.)

IMDG: III (For reference only, please check.)

IATA: III (For reference only, please check.)

ADR/RID: No

IMDG: No

IATA: No

no data available

no data available

Depending on the degree of exposure, periodic medical examination is suggested.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.