4-chloroaniline SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： 4-chloroaniline
- CAS： 106-47-8
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 3, Dermal
Skin sensitization, Category 1
Acute toxicity - Category 3, Inhalation
Carcinogenicity, Category 1B
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H301 Toxic if swallowed
H311 Toxic in contact with skin
H317 May cause an allergic skin reaction
H331 Toxic if inhaled
H350 May cause cancer
H410 Very toxic to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P271 Use only outdoors or in a well-ventilated area.
P203 Obtain, read and follow all safety instructions before use.
P273 Avoid release to the environment.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P333+P317 If skin irritation or rash occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P318 IF exposed or concerned, get medical advice.
P391 Collect spillage.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: 4-chloroaniline
- Common names and synonyms: 4-chloroaniline
- CAS number: 106-47-8
- EC number: 203-401-0
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Refer for medical attention.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Refer for medical attention .
Most important symptoms/effects, acute and delayed
Inhalation or ingestion causes bluish tint to fingernails, lips, and ears indicative of cyanosis; headache, drowsiness, and nausea, followed by unconsciousness. Liquid can be absorbed through skin and cause similar symptoms. Contact with eyes causes irritation. (USCG, 1999)
Indication of immediate medical attention and special treatment needed, if necessary
Methylene blue, alone or in combination with oxygen, is indicated as treatment in nitrite-induced methemoglobinemia.
SECTION 5: Firefighting measures
Suitable extinguishing media
Water, dry chemical, foam or carbon dioxide
Specific hazards arising from the chemical
Special Hazards of Combustion Products: Irritating and toxic hydrogen chloride and oxides of nitrogen may form in fires. (USCG, 1999)
Special protective actions for fire-fighters
Use water spray, powder, foam, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: P3 filter respirator for toxic particles and chemical protection suit. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: P3 filter respirator for toxic particles and chemical protection suit. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Removal of chloroaniline from wastewater by electrochemical treatment is discussed.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from strong oxidants and food and feedstuffs.Storage temperature: ambient.
SECTION 8: Exposure controls/personal protection
Control parameters
MAK: skin absorption (H); sensitization of skin (SH); carcinogen category: 2
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety goggles or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Solid. Crystalline.
-
Colour：
White or pale yellow solid.
-
Odour：
SLIGHTLY SWEETISH; CHARACTERISTIC AMINE ODOR
-
Melting point/freezing point：
72.5 °C. Atm. press.:101.3 kPa.
-
Boiling point or initial boiling point and boiling range：
232 °C. Atm. press.:101.3 kPa.
-
Flammability：
Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
120 °C. Atm. press.:101.3 kPa.
-
Auto-ignition temperature：
685°C
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
no data available
-
Solubility：
Miscible with water
-
Partition coefficient n-octanol/water：
log Pow = 1.83. Temperature:25 °C.
-
Vapour pressure：
0.15 mm Hg. Temperature:25 °C.;10 mm Hg. Temperature:102.1 °C.;40 mm Hg. Temperature:°C.
-
Density and/or relative density：
1.169. Temperature:77 °C.
-
Relative vapour density：
4.4 (vs air)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on burning. This produces toxic and corrosive fumes including hydrogen chloride and nitrogen oxides. Reacts violently with oxidants.
Chemical stability
Stability during transport: stable.
Possibility of hazardous reactions
P-CHLOROANILINE is incompatible with oxidizing agents. Also incompatible with acids, acid chlorides, acid anhydrides and chloroformates. Subject to exothermic decomposition during high-temperature distillation. Incompatible with nitrous acid. (NTP, 1992)
Conditions to avoid
no data available
Incompatible materials
Very vigorous reactions may occur with strong oxidants.
Hazardous decomposition products
When heated to decomposition it emit toxic fumes of /hydrogen chloride and nitrogen oxides/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male) - > 200 - < 480 mg/kg bw.
- Inhalation: LC50 Rat (Crl:CD, male) inhalation 2340 mg PCA/cu m/4 hr (head-only exposure) PCA vapor aerosol mixture: respirable fraction 57-95%
- Dermal: LD50 - cat - 239 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Cancer Classification: Group B2 Probable Human Carcinogen
Reproductive toxicity
no data available
STOT-single exposure
The substance is irritating to the eyes. The substance may cause effects on the red blood cells. This may result in lesions of blood cells and the formation of methaemoglobin. Medical observation is indicated. The effects may be delayed.
STOT-repeated exposure
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the spleen. Tumours have been detected in experimental animals but may not be relevant to humans. See Notes.
Aspiration hazard
A harmful concentration of airborne particles can be reached quickly when dispersed.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50 Lepomis macrochirus (Bluegil)l 2.4 mg/L/96 hr /Conditions of bioassay not specified in source examined
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - > 0.008 - < 38 ppm - 24 h.
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
The metabolism of 4-chloroaniline by isolated cultures of the soil fungus fusarium oxysporum schlecht was studied. 2-amino-5-chlorophenol was positively identified as metabolite of 4-chloroaniline in the isolated soil fungus cultures.
Bioaccumulative potential
The average BCFs in the whole body of carp exposed to 4-chloroaniline in flow-through experiments (25 deg C, 12 L/hr) for 24 to 336 hr at high (10.4 ug/L) and low (0.30 ug/L) exposure levels were 0.8 and 1.7, respectively(3). Excretion was rapid with depuration rates and half-lives of 0.16/hr and 4.3 hr, respectively(3). Therefore, 4-chloroaniline should not bioconcentrate in fish. Uptake was rapid in static tests (0.20 umol/L, 26 deg C) on zebrafish and a BCF of 8.1 was obtained for 24 hr exposure(4). Elimination was best described by a two compartment first order model(4). After 53 hr of depuration, the concn of 4-chloroaniline in the zebrafish declined to 12.0% of the steady state value. The log BCF in Golden orfe was <1.30 for 3 day exposure(1). The 24-hr log BCF in green alga was 3.08 (dry wt basis(2)) and 2.42 (wt weight basis(1)). A BCF of 13.4 was reported for guppy (Poecilia reticulata)(5). According to a classification scheme(6), these BCF values suggest the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
The Koc for 5 Belgium soils ranged from 230-469(1). The adsorption isotherm was not linear and the exponent in the Freundlich adsorption isotherm averaged 0.70(1). The Koc for 5 German soils ranged from 96 to 1,530 with the Freundlich exponent ranging from 0.92 to 1.23(2). From adsorption studies on three soils with radically different organic carbon and clay contents, it was shown that the percent (14)C labeled 4-choloroaniline that was bound increased with the organic carbon content of the soil and decreased with its clay content(3). Stronger binding at low concns, particularly with the soil of low organic carbon content, suggests that there are a limited number of available binding sites on the soil(3). At the lower concn (5ppm), percent binding ranged from 46-78%(3). The Koc to colloidal organic matter in ground water was high, 5,550, suggesting that adsorption onto this microparticulate matter could effectively increase the solubility and leaching of 4-chloroaniline into landfill groundwater(4). According to a classification scheme(5), Koc values between 50-150 suggest that 4-chloroaniline is expected to have high mobility in soil, Koc values >500 to >5000 suggest 4-chloroaniline is expected to have low to no mobility in soil. Aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(7,8), suggesting that mobility may be much lower in some soils(SRC). Adsorption of 4-chloroaniline by 5 soils was studied in the lab; adsorption decreased with the depth of the soil sample, due to decreased organic carbon(6). Adsorption coefficients of 4-chloroaniline and 4 other organic compounds for organic and inorganic materials and natural soils were determined(2). With few exceptions, the organic constituents of the soils were mainly responsible for their adsorption properties(2). Cellulose appeared to be a well-suited model adsorbent for simulating the relative adsorption behavior of the chemicals(2). The pKa of 4-chloroaniline is 3.98(9), indicating that this compound will primarily exist in its nonionic form in the environment.
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN2018 (For reference only, please check.)
IMDG: UN2018 (For reference only, please check.)
IATA: UN2018 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: CHLOROANILINES, SOLID (For reference only, please check.)
IMDG: CHLOROANILINES, SOLID (For reference only, please check.)
IATA: CHLOROANILINES, SOLID (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: II (For reference only, please check.)
IMDG: II (For reference only, please check.)
IATA: II (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Depending on the degree of exposure, periodic medical examination is suggested.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.