4-chloro-o-cresol SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： 4-chloro-o-cresol
- CAS： 1570-64-5
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Skin corrosion, Sub-category 1A
Acute toxicity - Category 3, Inhalation
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H314 Causes severe skin burns and eye damage
H331 Toxic if inhaled
H400 Very toxic to aquatic life
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316 Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P391 Collect spillage.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: 4-chloro-o-cresol
- Common names and synonyms: 4-chloro-o-cresol
- CAS number: 1570-64-5
- EC number: 216-381-3
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention .
Most important symptoms/effects, acute and delayed
SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin, eyes and mucous membranes. ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes. It can cause irritation of the skin, eyes and mucous membranes. (NTP, 1992)
Indication of immediate medical attention and special treatment needed, if necessary
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilation if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Monitor for shock and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport . Administer activated charcoal . Do not use emetics. Cover skin burns with dry, sterile dressings after decontamination . Maintain body temperature. Phenols and related compounds
SECTION 5: Firefighting measures
Suitable extinguishing media
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
Specific hazards arising from the chemical
This chemical is probably combustible. (NTP, 1992)
Special protective actions for fire-fighters
Use water spray, foam, dry powder, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Do NOT let this chemical enter the environment.
Environmental precautions
Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Do NOT let this chemical enter the environment.
Methods and materials for containment and cleaning up
Gamma-ray-induced degradation on nonbiodegradable organic compounds is demonstrated on chlorophenols and 4-chlorocresol. The oxidation in aqueous solutions with air at doses up to 1 Mrad results in complete dechlorination. The following organic compounds have been identified in the case of 4-chlorocresol as oxidation products: oxalic acid, formic acid (HCO2H), acetic acid (HOAC), glyoxal, mesoxalic acid, mesoxalic acid semialdehyde.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
SECTION 8: Exposure controls/personal protection
Control parameters
no data available
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation, local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Solid. Crystalline.
-
Colour：
Munsell Colour 5 Y 8/1 White.
-
Odour：
Mild, phenolic odor
-
Melting point/freezing point：
>= 46 - <= 50 °C.;>= 319 - <= 49.85°C.
-
Boiling point or initial boiling point and boiling range：
Ca. 231 °C. Atm. press.:Ca. 1 atm. Remarks:No decomposition temperature recorded.
-
Flammability：
Combustible.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
Ca. 114.6 °C. Atm. press.:Ca. 760 mm Hg.
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
no data available
-
Solubility：
less than 1 mg/mL at 59° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
log Pow = Ca. 3.09.
-
Vapour pressure：
26.66 Pa. Temperature:25 °C. Remarks:See additional information below.
-
Density and/or relative density：
Ca. 0.48 g/cm3. Temperature:20 °C.
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on burning. This produces toxic and corrosive fumes.
Chemical stability
no data available
Possibility of hazardous reactions
P-CHLORO-O-CRESOL can react vigorously with concentrated sodium hydroxide solutions. Also reacts with other bases, acid chlorides, acid anhydrides, and oxidizing agents. Corrodes steel, brass, copper and copper alloys [NTP, 1992)]. A large quantity left in contact with concentrated sodium hydroxide solution for 3 days reacted violently, attaining red heat and evolving fumes that ignited explosively. The heat of reaction dissipated poorly because of the high viscosity of the mixture [Quart. Safety Summ., 1957, 28, 39].
Conditions to avoid
no data available
Incompatible materials
A large quantitiy (700 kg) of /4-chloro-2-methylphenol/, left in contact with concentrated sodium hydroxide soln for 3 days, decomposed, attaining red heat and evolving fumes which ignited explosively. Although this could not be reproduced under laboratory conditions, it is believed that exothermic hydrolysis to the hydroquinone (possibly with subsequent aerobic oxidation to the quinone) occurred, the high viscosity of the liquid preventing dissipation of heat.
Hazardous decomposition products
When heated to decomp it emits toxic fumes of /hydrogen chloride/ and phosgene.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male/female) - ca. 3 195 mg/kg bw. Remarks:Range 2,698 -3,834 mg/kg.
- Inhalation: LC50 - rat (male/female) - ca. 0.9 mg/L air (nominal).
- Dermal: LD50 - rat (male/female) - ca. 2 240 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is corrosive to the eyes, skin and respiratory tract. Inhalation may cause lung oedema. See Notes. Corrosive on ingestion.
STOT-repeated exposure
no data available
Aspiration hazard
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 1 mg/L - 48 h.
- Toxicity to algae: EC50 - Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) - ca. 14.81 mg/L - 72 h.
- Toxicity to microorganisms: EC10 - Pseudomonas putida - ca. 37 mg/L - 17 h.
Persistence and degradability
AEROBIC: Degradation rates for 4-chloro-2-methylphenol were 2.8 ug/l/day at an initial concentration of 18 ug/l in a sea water shake flask die-away test and 0.04 ug/l/day at an initial concentration of 3.6 ug/l in a waste water shake flask die-away test(1). Mixed cultures of phenol adapted microorganisms exhibited moderate oxygen uptake as the test concentration of 4-chloro-2-methylphenol was reduced from 80 ppm to 50 ppm over a 3 hour period(2,3). 4-Chloro-2-methylphenol, present at 100 mg/l, reached 0 percent of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/l and the Japanese MITI test(4). An activated sludge pilot plant was operated at 4, 6, and 9 day sludge ages with the same influent settled sewage; higher concentrations of 4-chloro-2-methylphenol were seen in the effluent from the unit run at 4 day sludge age(5). A sludge-soil column study was able to demonstrate the breakdown of 4-chloro-2-methylphenol at an initial concentration of 304 mg/kg to 20 mg/kg after 97 days with successive first order rate constants of 0.0489 for the first 15 days and 0.0406 for the remaining 82 days, which equates to a half-life of 14 days(6). 4-Chloro-2-methylphenol was almost completely degraded from 2 natural soils treated at 10 ppm within an 8 week incubation period at 25 deg C, while nearly a 90 percent reduction occurred after 4 weeks time(7). At a concentration of 200 and 2000 ppm, 12 weeks were required to achieve an approximate 95 percent reduction of initial substrate(7). 4-Chloro-2-methylphenol was degraded similarly in sandy clay and silty clay soils(8). Half-lives were 21 days in both types of soil at initial concentrations of 10 and 1000 ppm each(8). The first order rate constant for the degradation of 4-chloro-2-methylphenol was 0.0337 in sandy clay soil and 0.0334 in silty clay soil(8).
Bioaccumulative potential
Bioconcentration tests on carp with an average lipid content of 4.9 percent were conducted in a continuous flow system with six weeks exposure(1). BCF values in carp measured at initial 4-chloro-2-methylphenol concentrations of 2 ug/l and 20 ug/l ranged from 6.4-14 and 8.2-28, respectively(1). According to a classification scheme(2), these BCF ranges suggest the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
The Koc values for 4-chloro-2-methylphenol range from 124 to 645(1). According to a classification scheme(2), these Koc values suggest that 4-chloro-2-methylphenol is expected to have moderate mobility in soil.
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN3437 (For reference only, please check.)
IMDG: UN3437 (For reference only, please check.)
IATA: UN3437 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: CHLOROCRESOLS, SOLID (For reference only, please check.)
IMDG: CHLOROCRESOLS, SOLID (For reference only, please check.)
IATA: CHLOROCRESOLS, SOLID (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: II (For reference only, please check.)
IMDG: II (For reference only, please check.)
IATA: II (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort.Rest and medical observation is therefore essential.Substance may be transported in a molten form.