Biphenyl-4-ylamine SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Biphenyl-4-ylamine
- CAS： 92-67-1
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Carcinogenicity, Category 1A
GHS label elements, including precautionary statements
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Pictogram(s)
- Signal word Danger
H302 Harmful if swallowed
H350 May cause cancer
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Biphenyl-4-ylamine
- Common names and synonyms: Biphenyl-4-ylamine
- CAS number: 92-67-1
- EC number: 202-177-1
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Refer for medical attention.
Remove contaminated clothes. Rinse and then wash skin with water and soap.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Refer for medical attention .
Most important symptoms/effects, acute and delayed
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Headache, dizziness; drowsiness, dyspnea (breathing difficulty); ataxia, lassitude (weakness, exhaustion); methemoglobinemia; urinary burning; acute hemorrhagic cystitis; [potential occupational carcinogen] Target Organs: Bladder, skin (NIOSH, 2016)
Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Nitrates, Nitrites, and Related Compounds
SECTION 5: Firefighting measures
Suitable extinguishing media
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
Specific hazards arising from the chemical
This chemical is probably combustible. (NTP, 1992)
Special protective actions for fire-fighters
Use water spray, dry powder, foam, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: complete protective clothing including self-contained breathing apparatus. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: complete protective clothing including self-contained breathing apparatus. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from strong oxidants and acids. Well closed.Keep container tightly closed in a dry and well-ventilated place.
SECTION 8: Exposure controls/personal protection
Control parameters
TLV: (skin); A1 (confirmed human carcinogen).MAK: skin absorption (H); carcinogen category: 1; germ cell mutagen group: 3A
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety goggles, face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use closed system or ventilation.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
PHYSICAL DESCRIPTION: Colorless to yellowish-brown crystals or light brown solid. (NTP, 1992)
-
Colour：
Colorless crystals
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Odour：
Floral odor
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Melting point/freezing point：
52-54°C
-
Boiling point or initial boiling point and boiling range：
191°C (15 mmHg)
-
Flammability：
Combustible Solid, but must be preheated before ignition possible.
-
Lower and upper explosion limit/flammability limit：
no data available
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Flash point：
113°C
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Auto-ignition temperature：
842° F (NTP, 1992)
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
no data available
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Solubility：
less than 0.1 mg/mL at 66° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
log Kow = 2.86 at pH 7.5
-
Vapour pressure：
1 mm Hg at 227° F (NIOSH, 2016)
-
Density and/or relative density：
1.077g/cm3
-
Relative vapour density：
5.8 (Air = 1) at boiling point of 4-aminodiphenyl
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
On combustion, forms toxic gases. Reacts with strong oxidants and acids.
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
Slight to moderate when exposed to heat, flames, (sparks) or powerful oxidizers.4-AMINOBIPHENYL is a weak base. Incompatible with acids and acid anhydrides. Forms salts with hydrochloric acid and sulfuric acid. Can be diazotized, acetylated and alkylated. (NTP, 1992). May react with strong oxidizing agents.
Conditions to avoid
no data available
Incompatible materials
Incompatible materials: Strong oxidizing agents.
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions - Carbon oxides, nitrogen oxides (NOx).
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 500 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Sufficient evidence of carcinogenicity in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 1: The agent is carcinogenic to humans.
Reproductive toxicity
4-Aminobiphenyl has been shown to cross the placenta in humans and has been detected in fetal blood. No other information is available on the reproductive or developmental effects of 4-aminobiphenyl in humans or animals.
STOT-single exposure
no data available
STOT-repeated exposure
The substance may have effects on the bladder. This may result in inflammation and tissue lesions. This substance is carcinogenic to humans. See Notes.
Aspiration hazard
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: 4-Biphenylamine was 0-50% degraded at the end of a 28 day test period in a static biodegradability test in which 2 mg/L of the compound was seeded with sludge, mineral salts, 5 mg/l yeast, with 7-day static incubation followed by 3 weekly subcultures(1); this was considered as slowly degraded with acclimation under the conditions of this test system(1). In another static system procedure where a 1% solution of the chemical in an emulsifier was added to a bacterial suspension at a concentrations of 1 to 2 ppm, 4-biphenylamine was 50% degraded at the end an initial 7-day incubation period(2). Two analogous compounds, aniline (phenylamine) and biphenyl, were classified as readily biodegradable by the Japanese MITI test (OECD Guideline 301C)(3). Aniline and biphenyl, present at 100 mg/L, reached 85 and 66% of their respective theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(3).
Bioaccumulative potential
An estimated BCF of 36 was calculated in fish for 4-biphenylamine(SRC), using a log Kow of 2.86(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).
Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of 4-biphenylamine can be estimated to be 2470(SRC). According to a classification scheme(2), this estimated Koc value suggests that 4-biphenylamine is expected to have slight mobility in soil. Aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(3,4), suggesting that mobility may be lower in some soils(SRC).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Packing group, if applicable
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Depending on the degree of exposure, periodic medical examination is suggested.Special attention should be given to urine sediment and cytology.Special attention should be given to blood in urine.Do NOT take working clothes home.