2,4,5-trichlorophenol SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： 2,4,5-trichlorophenol
- CAS： 95-95-4
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Skin irritation, Category 2
Eye irritation, Category 2
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Warning
H302 Harmful if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H410 Very toxic to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P273 Avoid release to the environment.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P391 Collect spillage.
none
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: 2,4,5-trichlorophenol
- Common names and synonyms: 2,4,5-trichlorophenol
- CAS number: 95-95-4
- EC number: 202-467-8
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest.
Remove contaminated clothes. To remove substance use polyethylene glycol 300 or vegetable oil. Rinse and then wash skin with water and soap.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Refer for medical attention .
Most important symptoms/effects, acute and delayed
SYMPTOMS: Symptoms of exposure to large amounts of this compound may include irritation of the skin, eyes, nose and throat. The dust may cause swelling and injury to the eyes. Eye contact may also result in conjunctivitis and slight to moderate corneal injuries. Other toxic effects include decrease of activity, motor weakness and convulsive seizures. It also causes lung, kidney and liver damage; an increase and then a decrease in respiratory rate, decrease in urine output, fever, increased bowel action and collapse. ACUTE/CHRONIC HAZARDS: This compound is an irritant of the skin, eyes, nose and throat. When heated to decomposition it emits toxic fumes of chloride ion; decomposition may be violent. There is limited evidence that this compound is a human carcinogen. (NTP, 1992)
Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Phenols and related compounds
SECTION 5: Firefighting measures
Suitable extinguishing media
If material /is/ involved in /a/ fire, extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn or burns with difficulty. Trichlorophenol
Specific hazards arising from the chemical
Literature sources indicate that this chemical is nonflammable. (NTP, 1992)
Special protective actions for fire-fighters
Use foam, powder, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Land Spill Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with plastic sheet to prevent dissolving in rain or fire fighting water. Trichlorophenol
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. NO contact with strong oxidizing agents. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from strong oxidants and food and feedstuffs. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.Storage temp: ambient
SECTION 8: Exposure controls/personal protection
Control parameters
| Component | 2,4,5-trichlorophenol | |||
|---|---|---|---|---|
| CAS No. | 95-95-4 | |||
| Limit value - Eight hours | Limit value - Short term | |||
| ppm | mg/m3 | ppm | mg/m3 | |
| Austria | 0,012 | 0,1 | 0,048 | 0,4 |
| Denmark | ? | 0,5 | ? | 1 |
| Sweden | ? | 0,5 | ? | 1,5 (1) |
| Remarks | ||||
| Sweden | (1) 15 minutes average value | |||
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety goggles, face shield or eye protection in combination with breathing protection if powder.
Protective gloves. Protective clothing.
Use local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
PHYSICAL DESCRIPTION: Colorless needles, gray flakes or off-white lumpy solid. Phenolic odor. Formerly used as a fungicide and bactericide.
-
Colour：
Needles from alcohol, petroleum ether
-
Odour：
Strong phenolic odor
-
Melting point/freezing point：
19°C(lit.)
-
Boiling point or initial boiling point and boiling range：
115°C/10mmHg(lit.)
-
Flammability：
Combustible under specific conditions. Gives off irritating or toxic fumes (or gases) in a fire.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
95°C(lit.)
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
-
pH：
Weak monobasic acid
-
Kinematic viscosity：
no data available
-
Solubility：
less than 1 mg/mL at 70° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
log Kow = 3.72
-
Vapour pressure：
1 mm Hg at 162° F ; 5 mm Hg at 215.8° F (NTP, 1992)
-
Density and/or relative density：
1,678 g/cm3
-
Relative vapour density：
greater than 1 (NTP, 1992) (Relative to Air)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
May explode on heating to decomposition. Decomposes on heating and on contact with strong oxidants. This produces toxic and irritating fumes (chlorine, hydrochloric acid). The substance is a weak acid. Reacts in an alkaline medium at high temperatures producing highly toxic chlorinated dioxins.
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
Non-combustible. /Trichlorophenol/2,4,5-TRICHLOROPHENOL is a weak monobasic acid. Incompatible with acid chlorides, acid anhydrides and oxidizing agents. Produces dioxin in alkaline medium at high temperatures (NTP, 1992)
Conditions to avoid
no data available
Incompatible materials
The reaction of 2,4,5-trichlorophenol in an alkaline medium at high temperatures ... /produces/ ... dioxin .
Hazardous decomposition products
When heated to decomp, it emits toxic fumes of /hydrogen chloride/ and explodes.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 820 mg/kg; Solvent: fuel oil
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: There is limited evidence in humans for the carcinogenicity of combined exposures to polychlorophenols or to their sodium salts. ... There is inadequate evidence in experimental animals for the carcinogenicity of 2,4,5-trichlorophenol. ... Overall evaluation: Combined exposures to polychlorophenols or to their sodium salts are possibly carcinogenic to humans (Group 2B). Polychlorophenols
Reproductive toxicity
No information is available on the reproductive or developmental effects of 2,4,5-trichlorophenol in humans. In several studies of mice exposed to 2,4,5-trichlorophenol via gavage (experimentally placing the chemical in the stomach), no birth defects were observed. In one study, a reduction in litter size was reported. No changes in maternal or fetal parameters were noted in rats exposed to 2,4,5-trichlorophenol by injection. (4)
STOT-single exposure
The substance is severely irritating to the eyes, skin and respiratory tract.
STOT-repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the liver and kidneys. See Notes.
Aspiration hazard
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached when dispersed.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill) weight 1.16 g; Conditions: freshwater, static; Concentration: 1280 ug/L for 96 hr (95% confidence interval: 1160-1415 ug/L /32.7% purity
- Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (Water Flea) age <24 hr neonate; Conditions: freshwater, static, 25 deg C, pH 8.0, hardness 150 mg/L CaCO3, alkalinity 121 mg/L CaCO3; Concentration: 2080 ug/L for 48 hr
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: The rate of 2,4,5-trichlorophenol biodegradation (measured by CO2 evolution) in river water and sediment corresponded to half-lives of 690 and 23 days, respectively(1). Using the Japanese MITI test, 2,4,5-trichlorophenol present at 100 ppm underwent <30% degradation in 2 weeks using an activated sludge at 30 ppm(2). Mixed microbial cultures isolated from toluene and phenol activated sludge, resulted in 50% biodegradation of 2,4,5-trichlorophenol in 2 days(3). 2,4,5-Trichlorophenol, present at 50 mg/L, took >47 and >72 days for complete degradation when added to 2 different soil suspensions(4). 2,4,5-Trichlorophenol was aerobically degraded 72% and 9% in 80 days in non-sterile and sterile clay loam, respectively(5). Microbial degradation, volatilization, and photodecomposition were ruled out in the sterile soil indicating that other mechanisms contribute to degradation(5). An aerobic biodegradation half-life of 23 days was determined for 2,4,5-trichlorophenol from a river die-away test(6). Biodegradation half-life (measured by loss of UV absorbance) for 10 ug/L 2,4,5-trichlorophenol added to a soil suspension was 15 days(7). Soil microbes metabolized 2,4,5-trichlorophenol to 3,5-dichlorocatechol, 4-chlorocatechol, succinate, cis,cis-2,4-dichloromuconate, 2-chloro-4-(carboxymethylene)but-2-enolide, and chlorosuccinate(7).
Bioaccumulative potential
Using carp (Cyprinus carpio) which were exposed over an 8-week period to 10 and 1 ug/L of 2,4,5-trichlorophenol, respective measured BCFs were 121-484 and 232-825(1). A log BCF of 3.28 was reported for fathead minnows exposed to 2,4,5-trichlorophenol for 28 days(2). According to a classification scheme(3), these BCF values suggest that bioconcentration in aquatic organisms is high to very high(SRC).
Mobility in soil
Koc values of 89(1), 2300(2), and 1700 in Pahokee peat(3) have been reported. According to a classification scheme(4), these Koc values suggest that 2,4,5-trichlorophenol is expected to have high to slight mobility in soil. The pKa of 2,4,5-trichlorophenol is 7.43(5), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(6).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN2020 (For reference only, please check.)
IMDG: UN2020 (For reference only, please check.)
IATA: UN2020 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: CHLOROPHENOLS, SOLID (For reference only, please check.)
IMDG: CHLOROPHENOLS, SOLID (For reference only, please check.)
IATA: CHLOROPHENOLS, SOLID (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Some technical products may contain highly toxic impurities including polychlorinated dibenzo-p-dioxins and furans.Depending on the degree of exposure, periodic medical examination is suggested.If the substance is formulated with solvents also consult the ICSCs of these materials.Carrier solvents used in commercial formulations may change physical and toxicological properties.See ICSCs 588, 589, 590 and 1122.