2,4-D SDS

Acute toxicity - Category 4, Oral

Serious eye damage, Category 1

Skin sensitization, Category 1

Specific target organ toxicity – single exposure, Category 3

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

H302 Harmful if swallowed

H318 Causes serious eye damage

H317 May cause an allergic skin reaction

H335 May cause respiratory irritation

H412 Harmful to aquatic life with long lasting effects

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P271 Use only outdoors or in a well-ventilated area.

P273 Avoid release to the environment.

P301+P317 IF SWALLOWED: Get medical help.

P330 Rinse mouth.

P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P317 Get medical help.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P333+P317 If skin irritation or rash occurs: Get medical help.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P319 Get medical help if you feel unwell.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

SYMPTOMS: Symptoms of exposure to this material include weakness, muscle twitching, stupor, vomiting, abdominal cramps, diarrhea and anorexia. Central nervous system effects and myotonia can also occur. It is irritating to skin, eyes, mucous membranes and the upper respiratory tract. ACUTE/CHRONIC HAZARDS: This compound is irritating to skin, eyes, mucous membranes and upper respiratory tract. It emits toxic fumes when heated to decomposition. (NTP, 1992)

Dust may irritate eyes. Ingestion causes gastroentric distress, diarrhea, mild central nervous system depression, dysphagia, and possible transient liver and kidney injury. (USCG, 1999)

INHALATION: Inflamed mucous membranes. EYES: Contact may cause irritation and swelling. SKIN: Irritation, rashes and swelling. INGESTION: Weakness and lethargy, anorexia, diarrhea, spasticity and possible death from ventricular fibrillation and subsequent cardiac arrest. (USCG, 1999)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Chlorophenoxy herbicides and related compounds

Extinguishant: Carbon dioxide, dry chemical, foam, and water.

Flash point data for this compound are not available. It is probably combustible. (NTP, 1992)

Special Hazards of Combustion Products: Toxic and irritating hydrogen chloride or phosgene gases may form. (USCG, 1999)

Special Hazards of Combustion Products: Emits noxious fumes. Behavior in Fire: Emits noxious fumes, including chlorides. (USCG, 1999)

In case of fire in the surroundings, use appropriate extinguishing media.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered plastic containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered plastic containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Accidental Release Measures. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

NO contact with oxidizing agents. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Store in an area without drain or sewer access. Separated from strong oxidants and food and feedstuffs.Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Light sensitive. Moisture sensitive.

TLV: (inhalable fraction): 10 mg/m3, as TWA; A4 (not classifiable as a human carcinogen).MAK: (inhalable fraction): 2 mg/m3; peak limitation category: II(2); skin absorption (H); pregnancy risk group: C

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear safety goggles or eye protection in combination with breathing protection.

Protective gloves. Protective clothing.

Use local exhaust or breathing protection.

no data available

Decomposes on heating. This produces toxic fumes including hydrogen chloride. Reacts with strong oxidants. This generates fire and explosion hazard. Attacks some forms of coating and metals.

Stable under recommended storage conditions.

Not combustibleThis material is incompatible with strong oxidizers. (NTP, 1992)

no data available

Contact with strong oxidizers may cause fires or explosions.

When heated to decomposition it emits toxic fumes of /chlorides/.

no data available

no data available

no data available

no data available

EPA: Not classifiable as to human carcinogenicity. IARC: Possibly carcinogenic to humans. NTP: Not evaluated

no data available

The substance is irritating to the skin, respiratory tract and eyes. Exposure at high levels could cause effects on the nervous system.

See Notes.

A harmful concentration of airborne particles can be reached quickly on spraying or when dispersed, especially if powdered.

AEROBIC: 2,4-D is readily and rapidly degraded in soil(1). The kinetics of 2,4-D disappearance suggest that microorganisms are responsible(1). The rate will depend on a number of factors including presence of acclimated organisms, nutrient levels, moisture level, temperature, and concentration of 2,4-D(1-3). Typical half-lives range from less than 1 day to more than several weeks under the conditions used(4-8). Degradation with a mixture of microorganisms from activated sludge, soil and sediments lead to half-lives of 1.8-3.1 days under aerobic conditions(4,9). Particular species of microorganisms, of various types, have been isolated and shown to degrade phenoxyacetic acid herbicides in pure culture(1). Degradation of the phenoxyacetic acids proceeds by two main pathways(1). These are via a hydroxyphenoxy acetic acid intermediate or via the corresponding phenol(1). Warm, moist conditions and addition of organic matter stimulate degradation of 2,4-D(7). The breakdown of 2,4-D in two types of soil was investigated under dry and moist conditions and at two different temperatures(7). Generally, 2,4-D disappeared more rapidly from moist soil; after 14 days of a slow rate of disappearance, however, the removal rate from dry, sandy soil increased(7). Numbers of organisms degrading 2,4-D were initially much lower in sandy than in clay loams(7). However, numbers increased rapidly in sandy soils after the addition of the herbicide and, as a result, 2,4-D was eventually degraded more rapidly in sandy than in clay loams(7). In moist conditions, at 25 deg C, the half-life of 2,4-D was 7 days or less, whereas in dry conditions, at 35 deg C, it could be as long as 250 days(7). These latter conditions are unlikely to apply in most natural conditions where 2,4-D is likely to be used(7). First-order kinetics were observed for the degradation of 2,4-D in sandy loam and muck soils from Malaysia(10). Short half-lives were observed for 2,4-D in aerobic (3.4 days) muck soils(10).

An estimated BCF of 3 was calculated in fish for 2,4-D(SRC), using a log Kow of 2.81(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). The Japanese Chemicals Evaluation and Research Institute has classified 2,4-D as not highly bioaccumulative(4). A depuration half-life of 1.32 days was measured channel catfish (Ictalurus punctatus) exposed to 0.01 ppm 2,4-D over a period of 4 days(5). Rapid depuration was observed for rainbow trout (Salmo gairdneri), channel catfish (Ictalurus punctatus) and bluegill sunfish (Lepomis macrochirus) following 8-hr exposure to 0.3 or 1.0 mg/L C14-labeled 2,4-D butoxyethanol ester(6). Uptake by three seaweeds (Ulva sp, Enteromorpha sp, Rhodymenia sp) at pH 7.8 ranged from 0.01-0.03% of 2,4-D added using 25 ppb C14 ring-labeled 2,4-D(7). Bioaccumulation factors of <10 and 6 were reported for golfen orfe (Leuciscus idus mealnotus) and algae (Chlorella fusca), respectively(8).

Reported experimental 2,4-D (free acid) Koc values are 19.6 (average of 9 soils)(1) to 109.1 (average of 3 soils and range of 72.2-135.7)(2), and 20 to 79(3). According to a classification scheme(4), these Koc values suggest that 2,4-D is expected to have high to very high mobility in soil(SRC). The pKa of 2,4-D is 2.73(5). Anionic 2,4-D adsorption is affected by soil mineralogy (in particular iron and aluminum oxide content), exchangeable aluminum content, and soil phosphate content(6). Adsorption appears to increase with increasing organic content and decreasing pH of soil(7). Average mobility for 14 soils was 0.72 (Rf units), ranging from 0.41 for silty loam to 1.0 for sandy loam(7). In general little runoff occurs with 2,4-D or its amine salts and runoff behavior is the inverse of adsorption behavior(8). Thus, 2,4-D can be desorbed from mineral soils, but not from those containing much organic matter(8). Percolating water appears to be the principal means of movement and diffusion is important only for transport over very small distance(8). Geometric mean concentrations of leached 2,4-D ranged from 0.55-0.87 ug/L at a depth of 0.2 m following applications (rate 0.1-3.3 kg/ha-yr) of the herbicide and irrigation of home garden lawns(9). Upward movement of 2,4-D occurs when the soil surface dries or if rapid evaporation occurs(9). Thus, 2,4-D can be concentrated at the soil surface, where it can be photolyzed, transported by wind either on dust or in vapor form, or leached downwards again(9).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN3077 (For reference only, please check.)

IMDG: UN3077 (For reference only, please check.)

IATA: UN3077 (For reference only, please check.)

ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)

IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)

IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)

ADR/RID: 9 (For reference only, please check.)

IMDG: 9 (For reference only, please check.)

IATA: 9 (For reference only, please check.)

ADR/RID: III (For reference only, please check.)

IMDG: III (For reference only, please check.)

IATA: III (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

no data available

no data available

2,4-D is a chlorophenoxy-herbicide which, as a group, has been classified by IARC (1987) as possibly carcinogenic to humans, but the data on this specific substance are inconclusive.Carrier solvents used in commercial formulations may change physical and toxicological properties.