2,4-dichlorophenol SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： 2,4-dichlorophenol
- CAS： 120-83-2
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Acute toxicity - Category 3, Dermal
Skin corrosion, Sub-category 1B
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
GHS label elements, including precautionary statements
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Pictogram(s)
- Signal word Danger
H302 Harmful if swallowed
H311 Toxic in contact with skin
H314 Causes severe skin burns and eye damage
H411 Toxic to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P391 Collect spillage.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: 2,4-dichlorophenol
- Common names and synonyms: 2,4-dichlorophenol
- CAS number: 120-83-2
- EC number: 204-429-6
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Half-upright position. Refer immediately for medical attention.
Wear protective gloves when administering first aid. Remove contaminated clothes. See Notes. To remove substance use polyethylene glycol 400 or vegetable oil. Rinse skin with plenty of water or shower. Refer immediately for medical attention.
Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.
Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention.
Most important symptoms/effects, acute and delayed
Tremors, convulsions, shortness of breath, inhibition of respiratory system. (USCG, 1999)
Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Phenols and related compounds
SECTION 5: Firefighting measures
Suitable extinguishing media
Alcohol foam, foam, carbon dioxide, dry chemical.
Specific hazards arising from the chemical
Special Hazards of Combustion Products: Toxic gases can be evolved. Behavior in Fire: Solid melts and burns. (USCG, 1999)
Special protective actions for fire-fighters
Use water spray, foam, powder, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Activated carbon is a good method for removing chlorophenols from water. Competitive adsorption occurs between chlorophenols & humic substances present in nearly all municipal water supplies. This competition decr the capacity of carbon for chlorophenols. Chlorophenols
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Prevent build-up of electrostatic charges (e.g., by grounding). Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Fireproof. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing. Separated from strong oxidants and food and feedstuffs. Ventilation along the floor.SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.
SECTION 8: Exposure controls/personal protection
Control parameters
no data available
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Solid.
-
Colour：
White (5 Y 8/1 White).
-
Odour：
Strong medicinal
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Melting point/freezing point：
45 °C. Atm. press.:KPa. Remarks:The pressure at which the melting point is measured is not stated.
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Boiling point or initial boiling point and boiling range：
210 °C. Remarks:Boiling point at atmospheric pressure assumed although not confirmed.
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Flammability：
Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
Ca. 110.6 °C.
-
Auto-ignition temperature：
Remarks:Not applicable.
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
no data available
-
Solubility：
Partially miscible with water
-
Partition coefficient n-octanol/water：
log Pow = >= 3.21 - <= 3.25. Temperature:20 °C. Remarks:OECD Guideline 107, Rhodia reported value, 1984. Assigned reliability 2, valid with restrictions. Critical study for SIDS endpoint.;log Pow = 3. Remarks:OECD Guideline 117, Rhodia reported value, 1988. The temperature is not indicated. Assigned reliability 2, valid with restrictions.;log Pow = 2.92. Remarks:Rhodia reported value from peer reviewed handbook, 1982. The temperature is not indicated. Assigned relaibility 2, valid with restrictions.
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Vapour pressure：
8.7 Pa. Temperature:20 °C.;12 Pa. Temperature:25 °C.
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Density and/or relative density：
1.4 g/cm3. Temperature:49 °C.
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Relative vapour density：
5.62 (NTP, 1992) (Relative to Air)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on heating. This produces toxic fumes including chlorine and hydrogen chloride. Decomposes on burning. This produces toxic fumes including phosgene and dioxins. Reacts violently with acids and strong oxidants.
Chemical stability
no data available
Possibility of hazardous reactions
Combustible when exposed to heat or flame.Dust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc.2,4-DICHLOROPHENOL can react vigorously with oxidizing agents. Can also react with acids or acid fumes. Incompatible with acid chlorides and acid anhydrides. (NTP, 1992)
Conditions to avoid
no data available
Incompatible materials
Can react vigorously with oxidizing materials.
Hazardous decomposition products
When heated to decomposition ... it emits highly toxic fumes of /hydrogen chloride/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 580 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: There is limited evidence in humans for the carcinogenicity of combined exposures to polychlorophenols or to their sodium salts. There is evidence suggesting lack of carcinogenicity of 2,4-dichlorophenol in experimental animals. ... Overall evaluation: Combined exposures to polychlorophenols or to their sodium salts are possibly carcinogenic to humans (Group 2B). Polychlorophenols and their sodium salts
Reproductive toxicity
no data available
STOT-single exposure
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. The hot liquid may cause severe skin burns. Exposure to the molten substance may result in extensive skin absorption and rapid death. Inhalation of the vapour may cause lung oedema. See Notes. Medical observation is indicated. The substance may cause effects on the central nervous system.
STOT-repeated exposure
no data available
Aspiration hazard
A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; when in molten form, however, evaporation will be much faster.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50; Species: Danio rerio (Zebra danio); Conditions: static; Concentration: 3900 ug/L for 96 hr
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 2.8 mg/L - 48 h.
- Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - 1.13 mg/L - 72 h.
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: Using a static-culture flask-screening procedure with a settled wastewater inoculum, 2,4-dichlorophenol was found to be degradable with rapid microbial adaptation as 99-100% of initial concentration were degraded within 7 days(1). Using a Warburg respirometer and phenol-adapted bacteria (bacteria isolated from garden soil, river mud, compost and waste lagoon sediment), 95% of initial 2,4-dichlorophenol (200 ppm) was degraded within 7-10 days(2). Based on COD determination, 98% of initial 2,4-dichlorophenol was degraded in a BOD system with an activated sludge inoculum during a 20-day inoculation period(3). When activated sludge was exposed to 2,4-dichlorophenol at levels of 100 mg/L of sludge, 75% of the chemical disappeared in two days, and essentially 100% was gone in five days(4). However, 2,4-dichlorophenol, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum in the Japanese MITI test(5).
Bioaccumulative potential
A BCF range of 7.1 to 69 was calculated in fish for 2,4-dichlorophenol(SRC), using carp (Cyprinus carpio) which were exposed to 30 ppb test compound over an 8-week period(1). The BCF of 2,4-dichlorophenol in goldfish ranged from 34 to 100(3,4); the BCF in an unspecified fish specie was 100(3) and in trout was 10(4). According to a classification scheme(2), these BCF values suggest the potential for bioconcentration in aquatic organisms is low to moderate(SRC). The BCF of 2,4-dichlorophenol in algae ranged from 257 to 263(3,4).
Mobility in soil
The Koc of 2,4-dichlorophenol ranged from approximately 200 to 5,000 in soil adsorption studies using five mineral soils(1); the most important factors controlling the degree of adsorption were pH and percentage of iron oxide in the soil(1). In batch soil adsorption experiments conducted at pH 10, 2,4-dichlorophenol exhibited a soil equilibrium partition coefficient (Kp) of 0.0+/-0.5 indicating that adsorption was not occurring(2); 2,4-dichlorophenol has a pKa of 7.8 at 20 deg C which indicates that it will exist predominantly in the ionized form at pH 10(2); ionized phenols will generally not sorb to neutral or negatively charged soil organic matter as well as the non-dissociated form(2). The adsorption of the dichlorophenol isomers (including 2,4-dichlorophenol) onto Wyoming bentonite clay was found to be pH dependent with maximum adsorption occurring when ionization of the isomers was less than 50% based on pKa values(3). A 2,4-dichlorophenol Koc of 126 was measured in a clay loam soil from Michigan State University(4).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN2020 (For reference only, please check.)
IMDG: UN2020 (For reference only, please check.)
IATA: UN2020 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: CHLOROPHENOLS, SOLID (For reference only, please check.)
IMDG: CHLOROPHENOLS, SOLID (For reference only, please check.)
IATA: CHLOROPHENOLS, SOLID (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.Isolate contaminated clothing by sealing in a bag or other container.