4-methoxy-m-phenylenediamine SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： 4-methoxy-m-phenylenediamine
- CAS： 615-05-4
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Germ cell mutagenicity, Category 2
Carcinogenicity, Category 1B
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H302 Harmful if swallowed
H341 Suspected of causing genetic defects
H350 May cause cancer
H411 Toxic to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P273 Avoid release to the environment.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
P391 Collect spillage.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: 4-methoxy-m-phenylenediamine
- Common names and synonyms: 4-methoxy-m-phenylenediamine
- CAS number: 615-05-4
- EC number: 210-406-1
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest.
Remove contaminated clothes. Rinse and then wash skin with water and soap.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Refer for medical attention .
Most important symptoms/effects, acute and delayed
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Target Organs: Skin, thyroid, liver, reproductive system (NIOSH, 2016)
Indication of immediate medical attention and special treatment needed, if necessary
Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Monitor for shock and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 mg/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal . Cover skin burns with dry sterile dressings after decontamination . /Organic bases/Amines and related compounds/
SECTION 5: Firefighting measures
Suitable extinguishing media
Powder, water spray, foam, carbon dioxide.
Specific hazards arising from the chemical
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. For electric vehicles or equipment, ERG Guide 147 (lithium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. (ERG, 2016)
Special protective actions for fire-fighters
Use water spray, powder, foam, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into sealable containers. Do NOT let this chemical enter the environment.
Environmental precautions
Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into sealable containers. Do NOT let this chemical enter the environment.
Methods and materials for containment and cleaning up
PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. Chemical Carcinogens
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from strong oxidants. Well closed.Separated from strong oxidants Well closed.
SECTION 8: Exposure controls/personal protection
Control parameters
MAK: skin absorption (H); carcinogen category: 2
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
2,4-diaminoanisole is a colorless needles. Primarily used (along with salts such as 2,4-diaminoanisole sulfate) as a component of hair & fur dye formulations. (NIOSH, 2016)
-
Colour：
Needles from ether
-
Odour：
no data available
-
Melting point/freezing point：
66-68°C
-
Boiling point or initial boiling point and boiling range：
286.3°C at 760 mmHg
-
Flammability：
Combustible Solid
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
no data available
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
no data available
-
Solubility：
Soluble in alcohol, hot ether; slightly soluble in DMSO
-
Partition coefficient n-octanol/water：
log Kow = -0.31 (est)
-
Vapour pressure：
0.047 mm Hg at 25 deg C (est)
-
Density and/or relative density：
1.17g/cm3
-
Relative vapour density：
(air = 1): 4.77
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
NIOSH considers 2,4-diaminoanisole (and its salts) to be a potential occupational carcinogen.
Decomposes on heating. This produces toxic fumes including nitrogen oxides. Reacts with strong oxidants.
Chemical stability
no data available
Possibility of hazardous reactions
2,4-DIAMINOANISOLE is incompatible with the following: Strong oxidizers (NIOSH, 2016).
Conditions to avoid
no data available
Incompatible materials
Strong oxidizers.
Hazardous decomposition products
The substance decomposes on heating producing toxic fumes including nitrogen oxides.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 460 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: There is inadequate evidence in humans for the carcinogenicity of 2,4-diaminoanisole. There is sufficient evidence in experimental animals for the carcinogenicity of 2,4-diaminoanisole. Overall evaluation: 2,4-Diaminoanisole is possibly carcinogenic to humans (Group 2B). 2,4-Diaminoanisole and its salts
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
This substance is possibly carcinogenic to humans.
Aspiration hazard
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
no data available
Bioaccumulative potential
A range of BCF values of 1.3 to 4.6 were measured for carp exposed to 2 ppm 2,4-diaminoanisole over the course of a 6 week incubation period(1). According to a classification scheme(2), this BCF range suggests bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc for 2,4-diaminoanisole can be estimated to be 53(SRC). According to a classification scheme(2), this estimated Koc value suggests that 2,4-diaminoanisole is expected to have high mobility in soil. 2,4-Diaminoanisole is a weak base with an estimated pKa of 5.15(SRC), calculated by a method based on linear free energy relationships and perturbed molecular orbital theory(3). This estimated pKa indicates that 2,4-diaminoanisole will partially exist in the protonated form in acidic moist soils and cations generally adsorb to soils more strongly than their neutral counterparts(4). Moreover, anilines (aromatic amines) are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(5,6), suggesting that the mobility of 2,4-diaminoanisole may be much lower in some soils than indicated by the estimated Koc value(SRC).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN3077 (For reference only, please check.)
IMDG: UN3077 (For reference only, please check.)
IATA: UN3077 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 9 (For reference only, please check.)
IMDG: 9 (For reference only, please check.)
IATA: 9 (For reference only, please check.)
Packing group, if applicable
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Do NOT take working clothes home.