2-methylpyridine SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： 2-methylpyridine
- CAS： 109-06-8
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Flammable liquids, Category 3
Acute toxicity - Category 4, Oral
Acute toxicity - Category 4, Dermal
Eye irritation, Category 2
Acute toxicity - Category 4, Inhalation
Specific target organ toxicity – single exposure, Category 3
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Warning
H226 Flammable liquid and vapour
H302 Harmful if swallowed
H312 Harmful in contact with skin
H319 Causes serious eye irritation
H332 Harmful if inhaled
H335 May cause respiratory irritation
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.
P242 Use non-sparking tools.
P243 Take action to prevent static discharges.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower].
P370+P378 In case of fire: Use ... to extinguish.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P317 Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
P403+P235 Store in a well-ventilated place. Keep cool.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: 2-methylpyridine
- Common names and synonyms: 2-methylpyridine
- CAS number: 109-06-8
- EC number: 203-643-7
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Refer for medical attention.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Do NOT induce vomiting. Refer for medical attention .
Most important symptoms/effects, acute and delayed
INHALATION, INGESTION OR SKIN ABSORPTION: Narcosis, headache, nausea, giddiness, vomiting. EYES: Severe irritation. SKIN: Causes burns. INGESTION: Irritation and gastric upset. (USCG, 1999)
Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Aromatic hydrocarbons and related compounds
SECTION 5: Firefighting measures
Suitable extinguishing media
To fight fire, use carbon dioxide, dry chemical.
Specific hazards arising from the chemical
Special Hazards of Combustion Products: When heated to decompo- sition, emits toxic fumes of cyanide. Behavior in Fire: Heat may cause pressure buildup in closed containers. Use water to keep container cool. (USCG, 1999)
Special protective actions for fire-fighters
Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Environmental precautions
Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Personal protection: chemical protection suit including self-contained breathing apparatus.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames, NO sparks and NO smoking. Above 26°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Fireproof. Separated from oxidants.
SECTION 8: Exposure controls/personal protection
Control parameters
no data available
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation, local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Liquid.
-
Colour：
Colorless.
-
Odour：
Strong unpleasant odor
-
Melting point/freezing point：
-70 °C. Atm. press.:1.013 hPa.
-
Boiling point or initial boiling point and boiling range：
> 128 - < 129 °C. Atm. press.:760 mm Hg.
-
Flammability：
Flammable. Gives off irritating or toxic fumes (or gases) in a fire.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
39 °C. Atm. press.:101.3 kPa.
-
Auto-ignition temperature：
538 °C. Atm. press.:760 mm Hg. Remarks:Assume standard conditions.
-
Decomposition temperature：
no data available
-
pH：
/SRP/: Weak base
-
Kinematic viscosity：
no data available
-
Solubility：
greater than or equal to 100 mg/mL at 68° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
log Pow = 1.11. Temperature:20 °C. Remarks:Assume standard temperature and pressure.
-
Vapour pressure：
8 mm Hg. Temperature:20 °C. Remarks:Equivalent to 10.66 hPa.
-
Density and/or relative density：
0.944 g/cm3. Temperature:20 °C.
-
Relative vapour density：
3.2 (vs air)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on burning. This produces toxic fumes including nitrogen oxides. Reacts with oxidants. Attacks copper and its alloys.
Chemical stability
2-Methylpyridine is highly stable in aqueous solns .
Possibility of hazardous reactions
Moderate fire risk2-METHYLPYRIDINE is hygroscopic. This compound reacts with hydrogen peroxide, iron(II) sulfate, sulfuric acid, oxidizing agents, acids, and metals. (NTP, 1992)
Conditions to avoid
no data available
Incompatible materials
Mixtures with hydrogen peroxide + iron(II)sulfate + sulfuric acid may ignite & then explode.
Hazardous decomposition products
When heated to decomp, emits toxic fumes of nitrogen oxides.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male) - > 950 mg/kg bw. Remarks:950 mg/kg- highest dose tested.
- Inhalation: LC50 - rat (male/female) - > 9.4 mg/L air (analytical).
- Dermal: LD50 - rabbit (male/female) - > 200 - < 316 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is corrosive to the eyes and skin. The vapour is irritating to the respiratory tract. Exposure at high levels could cause unconsciousness.
STOT-repeated exposure
The substance defats the skin, which may cause dryness or cracking.
Aspiration hazard
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: EC50 - Danio rerio (previous name: Brachydanio rerio) - > 560 - < 1 000 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 320 mg/L - 48 h.
- Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - 320 mg/L - 72 h.
- Toxicity to microorganisms: NOEC - activated sludge - 20 mg/L - 28 d.
Persistence and degradability
AEROBIC: 2-Methylpyridine was reported as readily biodegradable in the MITI test(1). In an aerobic screening test using an enrichment culture obtained from soil as an inoculum, 100% degradation was obtained in 14 to 32 days(2). When this test was repeated under anaerobic conditions, degradation was much slower, requiring >97 days for complete biodegradation(2). Only 2.7% of the added 2-methylpyridine (initial concentration of 2 umoles/g) remained after 16 days following incubation in a silt loam soil(3). Complete biodegradation of 2-methylpyridine, initially added at 4 mg/L, was reported in aerobic groundwater incubated at 15 deg C for 4 days(4). In an aerobic column study where subsurface sediment was leached with contaminated groundwater, 65% of the initially applied 2-methylpyridine was removed after 5 weeks of operation(5). Complete biodegradation of 2-methylpyridine was observed in 24 days following incubation in a defined medium inoculated with soil(6). Contaminated groundwater, from the American Creosote Works Superfund site in Pensacola, FL, was incubated with 2-methylpyridine; 33, 33, 33, 66, and 100% degradation was reported after incubation for 1, 3, 5, 8, and 14 days, respectively(7). 2-Methylpyridine, present at 100 mg/L, reached 0.1% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(8).
Bioaccumulative potential
An estimated BCF of 3 was calculated for 2-methylpyridine(SRC), using a log Kow of 1.11(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Low bioconcentration was reported for tests using carp (Cyprinus carpio)(4); however, actual BCF values were not available(SRC).
Mobility in soil
The sorption behavior of 2-methylpyridine was studied in soil column tests using 5 Eurosoil reference soils having organic carbon content ranging from 0.33-1.85% and pH ranging from 5.2-8.6(1); measured Kd values ranging from 0.08 to 6.52(1) correspond to calculated Koc values of 4, 38, 70, 100 and 215(SRC); the lowest Koc value of 4 corresponds to Eurosoil 2 which had the highest pH value(8.6). The pKa of 2-methylpyridine is 5.96(2), indicating that this compound will exist partially in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(3). In the Eurosoil column tests(1), lowest adsorption occurred when 2-methylpyridine was in non-ionized form(1). Sorption of 2-methylpyridine to soil is primarily controlled by cation exchange and surface complex formation(1,4). According to a classification scheme(5), the Koc values suggest that 2-methylpyridine is expected to have very high to moderate mobility in soil.
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN2313 (For reference only, please check.)
IMDG: UN2313 (For reference only, please check.)
IATA: UN2313 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: PICOLINES (For reference only, please check.)
IMDG: PICOLINES (For reference only, please check.)
IATA: PICOLINES (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 3 (For reference only, please check.)
IMDG: 3 (For reference only, please check.)
IATA: 3 (For reference only, please check.)
Packing group, if applicable
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
See ICSCs 0802 and 0803.