2-methyl-4,6-dinitro-phenol SDS

Acute toxicity - Category 2, Oral

Acute toxicity - Category 1, Dermal

Skin irritation, Category 2

Serious eye damage, Category 1

Skin sensitization, Category 1

Acute toxicity - Category 2, Inhalation

Germ cell mutagenicity, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

H300 Fatal if swallowed

H310 Fatal in contact with skin

H315 Causes skin irritation

H318 Causes serious eye damage

H317 May cause an allergic skin reaction

H330 Fatal if inhaled

H341 Suspected of causing genetic defects

H410 Very toxic to aquatic life with long lasting effects

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P262 Do not get in eyes, on skin, or on clothing.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P284 [In case of inadequate ventilation] wear respiratory protection.

P203 Obtain, read and follow all safety instructions before use.

P273 Avoid release to the environment.

P301+P316 IF SWALLOWED: Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P316 Get emergency medical help immediately.

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P332+P317 If skin irritation occurs: Get medical help.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P317 Get medical help.

P333+P317 If skin irritation or rash occurs: Get medical help.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P320 Specific treatment is urgent (see ... on this label).

P318 IF exposed or concerned, get medical advice.

P391 Collect spillage.

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

Extremely toxic material; probable oral lethal dose is 5-50 mg/kg in humans or between 7 drops and 1 teaspoonful for a 70 kg (150 lb.) person. (EPA, 1998)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Dinitrophenol and Related Compounds

If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Keep run-off water out of sewers and water sources.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. (ERG, 2016)

Use water spray, foam, dry powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Environmental considerations: Land spill: Dig a pit, pond lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.

NO open flames. NO contact with oxidizing agents. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from strong oxidants and food and feedstuffs. Well closed.You should protect this material from exposure to light, and store it in a refrigerator.

TLV: 0.2 mg/m3, as TWA; (skin).MAK: skin absorption (H)

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear safety goggles or eye protection in combination with breathing protection.

Protective gloves. Protective clothing.

Use local exhaust or breathing protection.

no data available

Decomposes on burning. This produces toxic fumes including nitrogen oxides. Reacts violently with strong oxidants.

Stable during transport.

Dust explosion possible if in powder or granular form, mixed with air.This compound is incompatible with the following: Strong oxidizers (NIOSH, 2016). Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has pKa = 9.88). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. 4,6-DINITRO-O-CRESOL is explosive and is usually moistened with up to 10 percent water to reduce the hazard. [EPA, 1998].

no data available

Strong oxidizers.

When heated to decomposition it emits toxic fumes of /nitrogen oxides/.

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The substance is corrosive to the eyes. The substance is irritating to the skin. The substance may cause effects on the metabolic rate. Exposure at high levels could cause death.

no data available

A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.

AEROBIC: In a static-culture flask-screening procedure using a settled wastewater innoculum and a 7-day static incubation followed by three weekly subcultures, an initial 4,6-dinitro-o-cresol concentration of 5 ppm was degraded 52, 58, 56, and 51% in the original, first, second, and third subcultures after 7 days, respectively(1). With an initial concentration of 10 ppm, degradation was 0, 5, 11, and 14% after 7 days for the original, first, second, and third subcultures, respectively(1). 4,6-Dinitro-o-cresol was considered difficult to degrade, <20% elimination, within the prescribed test period, with the Zahn-Wellens test(2). A theoretical BOD of 22.3% was measured in a Warburg respirometer over a 3 hr incubation period using an initial concentration of 100 ppm and a mixed bacteria culture adapted to phenol(3). Mixed bacteria cultures (primarily Pseudomonadaceae) obtained from mud, soil, and water degraded only 1% of initial 4,6-dinitro-o-cresol (207 ppm) in 48 hr static flask tests using mineral solutions and 4,6-dinitro-o-cresol as the only carbon source(4). An activated sludge system receiving an influent of 11 ppb 4,6-dinitro-o-cresol was able to degrade 99% of the compound(5). In neutral and mildly alkaline soils, doses of 10-150 ppm 4,6-dinitro-o-cresol increased CO2 output by 10-30% over control, although there was a lag period before stimulation at concentrations above 50 ppm; in acidic soil, only low concentrations (1-20 ppm) produced significant stimulation(6). 4,6-Dinitro-o-cresol was found to increase CO2 production from soil microflora at low concentrations, but decrease at high concentrations(7). Biodegradation half-lives of 4,6-dinito-o-cresol in natural water were reported as 7 (aerobic) and 2.8 (anaerobic) days(8). No loss of 4,6-dinitro-o-cresol was observed when 4,6-dinitro-o-cresol was incubated in the dark with Texas soil (slightly basic sandy loam, 3.25% organic matter) and Mississippi soil (acidic soil, <1% organic matter) over a 65 day period(9). These soils had no previous exposure to industrial chemicals or wastes and did not receive any pre-treatment such as soil amendments or acclimated biological cultures(9). After a lag period of 80 days, 4,6-dinitro-o-cresol (25 ug/L) degraded quickly (rate constant 2.1 ug/L/day) under aerobic conditions in column experiments using groundwater and sediment from a shallow, unconfined, aquifer near Vejen, Denmark(10). 4,6-Dinitro-o-cresol, present at 100 mg/L, reached 4% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(11).

BCF values of <0.3-0.7 at 50 ug/L and <2.9 at 5 ug/L were measured for carp after a 6 week exposure(1). Using bioaccumulation test OECD 305E, which is a dynamic flow-through test, the BCF for zebra fish (Brachydanio rerio) were calculated from the kinetics of the uptake and clearance phases and a BCF of 1.4 was found for 2,4-dinitro-o-cresol(2). BCF values ranging from 56-64 were found for Pimephales promelas (fathead minnow) after a 24-30 day exposure to 4,6-dinitro-o-cresol (0.6-7.8 ug/L)(3). A BCF of 1.5 was reported for fish(4). According to a classification scheme(5), these BCF values suggest the potential for bioconcentration in aquatic organisms is low to moderate(SRC).

Koc values for 4,6-dinitro-o-cresol derived from experimental measurements have been reported as 257(1) and 300(2). A Koc for 4,6-dinitro-o-cresol of 23 was reported for sandy loam(3). According to a classification scheme(4), these Koc values suggest that 4,6-dinitro-o-cresol is expected to have very high to moderate mobility in soil. The pKa of 4,6-dinitro-o-cresol is 4.31(5), indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(6). In an aquifer laboratory and field study in Denmark, 4,6-dinitro-o-cresol had Kd sorption coefficient values ranging from 0.10 to 0.98 with stronger sorption occurring at lower pHs where the neutral form of the compound was at a higher percentage than at the higher pHs(7); this indicates the anionic form of 4,6-dinitro-o-cresol is more mobile in soil than the neutral form(SRC).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN3014 (For reference only, please check.)

IMDG: UN3014 (For reference only, please check.)

IATA: UN3014 (For reference only, please check.)

ADR/RID: SUBSTITUTED NITROPHENOL PESTICIDE, LIQUID, TOXIC (For reference only, please check.)

IMDG: SUBSTITUTED NITROPHENOL PESTICIDE, LIQUID, TOXIC (For reference only, please check.)

IATA: SUBSTITUTED NITROPHENOL PESTICIDE, LIQUID, TOXIC (For reference only, please check.)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

ADR/RID: I (For reference only, please check.)

IMDG: I (For reference only, please check.)

IATA: I (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

no data available

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Do NOT take working clothes home.Technical grade may cause skin sensitization.