2-pyridylamine SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： 2-pyridylamine
- CAS： 504-29-0
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 3, Dermal
Skin corrosion, Category 1
Serious eye damage, Category 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H301 Toxic if swallowed
H311 Toxic in contact with skin
H314 Causes severe skin burns and eye damage
H412 Harmful to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P317 Get medical help.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: 2-pyridylamine
- Common names and synonyms: 2-pyridylamine
- CAS number: 504-29-0
- EC number: 207-988-4
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Remove contaminated clothes. Rinse skin with plenty of water or shower.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .
Most important symptoms/effects, acute and delayed
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Irritation eyes, nose, throat; headache, dizziness; excitement; nausea; high blood pressure; respiratory distress; lassitude (weakness, exhaustion); convulsions; stupor Target Organs: central nervous system, respiratory system (NIOSH, 2016)
Indication of immediate medical attention and special treatment needed, if necessary
In cases of accidental skin contact, prompt, thorough skin cleansing & clothing change are necessary.
SECTION 5: Firefighting measures
Suitable extinguishing media
Extinguishant: Carbon dioxide, dry chemical, alcohol foam
Specific hazards arising from the chemical
This chemical is combustible. (NTP, 1992)
Special protective actions for fire-fighters
Use water spray, powder, alcohol-resistant foam, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. Carefully collect remainder. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Cover with 9:1 mixture of sand and soda ash. After mixing, transfer into a paper carton, stuffed with ruffled paper. Burn ... in furnace with afterburner and scrubber.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from food and feedstuffs, strong oxidants and strong acids.IN GENERAL MATERIALS ... TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS ... SHOULD BE STORED IN COOL, WELL-VENTILATED PLACE, OUT OF ... SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, & SHOULD BE PERIODICALLY INSPECTED & MONITORED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED.
SECTION 8: Exposure controls/personal protection
Control parameters
TLV: 0,5 ppm as TWA
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Solid. 1.White leaflets or large colorless crystals 2.White powder or crstals 3.White powder, leaflets, or crystals. 4. Leaflets, or large crystals.
-
Colour：
White.
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Odour：
Characteristic odor
-
Melting point/freezing point：
58.1 °C. Atm. press.:1 atm.
-
Boiling point or initial boiling point and boiling range：
210.6 °C. Atm. press.:1 atm.
-
Flammability：
Combustible Solid
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
Ca. 68 °C.
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
-
pH：
Ca. 9.4.
-
Kinematic viscosity：
no data available
-
Solubility：
Miscible with water
-
Partition coefficient n-octanol/water：
log Pow = Ca. 0.48. Temperature:25 °C. Remarks:PH is not available in the source of information.
-
Vapour pressure：
0.8 kPa. Temperature:25 °C.
-
Density and/or relative density：
1.065 g/cm3. Temperature:20 °C.
-
Relative vapour density：
3.25 (Air= 1)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on burning. This produces nitrogen oxides. Reacts with strong oxidants. This generates fire and explosion hazard. The solution in water is a strong base. It reacts violently with acid and is corrosive.
Chemical stability
no data available
Possibility of hazardous reactions
Dust explosion possible if in powder or granular form, mixed with air.2-AMINOPYRIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Reacts with oxidizing agents (NTP, 1992).
Conditions to avoid
no data available
Incompatible materials
Strong oxidizers
Hazardous decomposition products
Dangerous; when heated to decomp it emits highly toxic fumes of /nitrogen oxides/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 0.2 g/kg
- Inhalation: no data available
- Dermal: LD50 - guinea pig - 500 mg/kg.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is irritating to the eyes and skin. The substance may cause effects on the central nervous system. This may result in convulsions and respiratory depression. Exposure could cause an increase in blood pressure. Exposure far above the OEL could cause death.
STOT-repeated exposure
no data available
Aspiration hazard
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50 - Oryzias latipes - 6 mg/mL - 48 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 35 mg/L - 48 h.
- Toxicity to algae: EC50 - Green algae - 12 mg/L - 72 h.
- Toxicity to microorganisms: Salmonella typhimurium.
Persistence and degradability
AEROBIC: An aerobic biological screening study, which utilized a 10 mg/l yeast extract and an Aeric Ochraqualf soil for inocula, indicated that 2-aminopyridine is not readily biodegradable(1). At 28 deg C and a pH of 7, less than 1% of an initial 17 ppm of 2-aminopyridine was mineralized within 30 days as evidenced via the release of inorganic nitrogen(1). In addition, an acclimated aerobic soil grab sample study demonstrated slow biodegradation of 2-aminopyridine(2). 2-Aminopyridine was added to Fincastle silt loam (Aeric Ochraqualf) with a pH of 6.7 and incubated at 25 deg C(2). Within 64 days, 59.5% of the available nitrogen was released to inorganic forms(2). Sterilized controls lost 14.9% of the starting material to volatilization; but, did not release inorganic nitrogen(2). A screening test, which utilized 5 ml garden soil suspensions with glucose, yeast extract and mineral salts, compared aerobic and anaerobic biodegradation of 2-aminopyridine(3). 2-Aminopyridine completely degraded in greater than 96 days under both aerobic and anaerobic conditions(3). A 0% BOD was reported using 100 mg/l 2-aminopyridine in 30 mg/l sludge in 4 weeks(4).
Bioaccumulative potential
A BCF of 3.0-7.7 and <5.1-25 at a concentration of 0.1 and 0.01 mg/l, respectively, was measured for 2-aminopyridine(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low.
Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc for 2-aminopyridine can be estimated to be 45(SRC). According to a classification scheme(2), this estimated Koc value suggests that 2-aminopyridine is expected to have very high mobility in soil. However, the pKa of 2-aminopyridine is 6.86(3), indicating that this compound will partially exist in the protonated form in the environment and cations generally adsorb to organic carbon and clay more strongly than their neutral counterparts.
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN2671 (For reference only, please check.)
IMDG: UN2671 (For reference only, please check.)
IATA: UN2671 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: AMINOPYRIDINES (o-, m-, p,) (For reference only, please check.)
IMDG: AMINOPYRIDINES (o-, m-, p,) (For reference only, please check.)
IATA: AMINOPYRIDINES (o-, m-, p,) (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: II (For reference only, please check.)
IMDG: II (For reference only, please check.)
IATA: II (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
There is no odour warning even when toxic concentrations are present.The relation between odour and the occupational exposure limit cannot be indicated.