1,2,4-trichlorobenzene SDS

Acute toxicity - Category 4, Oral

Skin irritation, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

H302 Harmful if swallowed

H315 Causes skin irritation

H410 Very toxic to aquatic life with long lasting effects

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P273 Avoid release to the environment.

P301+P317 IF SWALLOWED: Get medical help.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P321 Specific treatment (see ... on this label).

P332+P317 If skin irritation occurs: Get medical help.

P362+P364 Take off contaminated clothing and wash it before reuse.

P391 Collect spillage.

none

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

Exposures to high concentrations via inhalation are potentially hazardous to the lungs, kidneys and liver. Prolonged or repeated exposures or short exposure to high concentrations via inhalation are potentially hazardous to the lungs, kidneys and liver. Prolonged or repeated exposure to the eyes is likely to result in moderate pain and transient irritation. Prolonged or repeated contact with the skin may result in moderate irritation and possible systemic effects. Ingestion: May cause kidney and liver damage. (USCG, 1999)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Aromatic hydrocarbons and related compounds

Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide.

Special Hazards of Combustion Products: May contain toxic hydrogen chloride and phosgene. Behavior in Fire: Decomposes to form hydrogen chloride and phosgene. (USCG, 1999)

Use water spray, powder, foam, carbon dioxide.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. If solid: sweep spilled substance into sealable containers. Then store and dispose of according to local regulations.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. If solid: sweep spilled substance into sealable containers. Then store and dispose of according to local regulations.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a POTW is acceptable only after review by the governing authority. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must meet Hazardous Material Criteria for disposal.

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from strong oxidants, acids and food and feedstuffs.1,2,4-Trichlorobenzenes are liquids at room temperature and are shipped in bulk in aluminum tank trucks and steel or stainless steel tank cars.

TLV: 5 ppm as STEL.MAK: skin absorption (H); carcinogen category: 3B.EU-OEL: 15.1 mg/m3, 2 ppm as TWA; 37.8 mg/m3, 5 ppm as STEL; (skin)

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear safety goggles or eye protection in combination with breathing protection.

Protective gloves.

Use ventilation, local exhaust or breathing protection.

no data available

Decomposes on burning. This produces toxic fumes including hydrogen chloride. Reacts violently with oxidants.

Stable at room temperature

Vapor explosion hazard indoors, outdoors, or in sewers. Runoff to sewer may creat fire or explosion hazard.1,2,4-TRICHLOROBENZENE can react vigorously with oxidizing materials (NTP, 1992). Yields hydrogen chloride and phosgene when heated to decomposition (USCG, 1999).

no data available

On contact with acids or acid fumes they evolve highly toxic /hydrogen chloride/ fumes. chlorides

When heated to decomp, it emits toxic fumes of /hydrogen chloride/.

no data available

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Cancer Classification: Group D Not Classifiable as to Human Carcinogenicity

No information is available on the reproductive or developmental effects of 1,2,4-trichlorobenzene in humans. Several studies reported that 1,2,4-trichlorobenzene did not affect fertility or viability nor cause increased resorptions, embryolethality, or teratogenicity in orally exposed rats. One oral study in rats reported retarded growth in fetuses.

The substance is irritating to the eyes, skin and respiratory tract.

The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the liver.

A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.

AEROBIC: A 0% theoretical BOD in sludge over a 2 week incubation period was observed for 1,2,4-trichlorobenzene(1). The aerobic biodegradation half-life of 1,2,4-trichlorobenzene in natural waters has been reported as 28 days(2). An 8-day theoretical BOD of 1% in a benzene acclimated sludge was observed for 1,2,4-trichlorobenzene(3). A 20-day theoretical BOD of 0% in municipal wastewater was observed for 1,2,4-trichlorobenzene while 20-day theoretical BODs of 78, 100 and 55% were observed for industrial wastewater(4). 1,2,4-Trichlorobenzene was dechlorinated 0.3-50.1% after 7 days incubation in soil amended with up to 4 mM bromoethanesulfonate, 2 mM sulfate and 7.5 mM hydrogen(5). After 4 days of incubation 28 uM of 1,2,4-trichlorobenzene was biodegraded to 1,4-dichlorobenzene and chlorobenzene(6). 1,2,4-Trichlorobenzene, under aerobic conditions, degraded 40% in dune sediment taken near Zandvoort, Netherlands after a 2 month lag time(7). 1,2,4-Trichlorobenzene was biodegraded 90% in groundwater samples under aerobic conditions(8). 1,2,4-Trichlorobenzene had influent concns of 90 and 8100 ug/L and effluent concns of <5.0 and <10 ug/L using an activated sludge with a daily mass loading of COD/bacterial mass ratios of 0.3 and 0.6(9).

BCF values of 420 to 1,140 were measured in carp exposed to 50 ug/L of 1,2,4-trichlorobenzene during a 6 week incubation period and BCF values of 120 to 1,300 were measured in carp exposed to 5 ug/L of 1,2,4-trichlorobenzene during a 6 week incubation period(1). The BCF value of 1,2,4-trichlorobenzene in fish in a flowing water system was 490 while the BCF value for trout in a static water system was 2400(2). Log BCFs of 3.11, 3.51, 3.36 and 3.57 were measured in 4 rainbow trout samples on a whole body basis, and 4.20, 4.57, 4.54 and 4.71 using lipid basis(3). Log BCFs of 3.10, 2.60, 1.91, 3.19, 3.32 and 3.31 were measured in Atlantic croaker, blue crab, spotted sea trout, blue catfish, fathead minnow and flagfish, respectively, on a whole body basis, and at 4.20, 4.57, 4.76, 4.90, 3.54, 4.68, 3.45, 4.54, 4.71 and 4.25, respectively, using lipid basis(3). 1,2,4-Trichlorobenzene had a log BCF of 2.95 in guppy (Poecilia reticulata)(4). A BCF of 491 was given for 1,2,4-trichlorobenzene in fish(5). 1,2,4-Trichlorobenzene at concns of 3.2 and 53 ng/L, in a flow-through system showed BCFs of 1300 and 3200, respectively, in rainbow trout exposed over 119 days(6). Fish continuously exposed to a mean measured aqueous concn of 2.9 ug/L of 1,2,4-trichlorobenzene had a estimated equilibrium bioconcentration factor of 182(7). According to a classification scheme(8), these BCF values suggest that bioconcentration in aquatic organisms is high to very high. Daphnids continuously exposed to a mean measured aqueous concn of 3.1 ug/L of 1,2,4-trichlorobenzene had a estimated equilibrium bioconcentration factor of 142(7).

Measured log Kocs of 3.1(1), 3.30(2), 3.35(3), 3.96(4-5), 4.03(6) were reported for 1,2,4-trichlorobenzene in soil. Koc values for 1,2,4-trichlorobenzene were 864 and 440 in soil and peaty soil(7). Log Koc values for peat soil and Dover soil taken from Zhejiang Province, China were 3.06 and 3.58(8). According to a recommended classification scheme(9), these Koc values suggest that 1,2,4-trichlorobenzene has moderate to no mobility in soil.

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN2321 (For reference only, please check.)

IMDG: UN2321 (For reference only, please check.)

IATA: UN2321 (For reference only, please check.)

ADR/RID: TRICHLOROBENZENES, LIQUID (For reference only, please check.)

IMDG: TRICHLOROBENZENES, LIQUID (For reference only, please check.)

IATA: TRICHLOROBENZENES, LIQUID (For reference only, please check.)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

ADR/RID: III (For reference only, please check.)

IMDG: III (For reference only, please check.)

IATA: III (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

no data available

no data available

The occupational exposure limit value should not be exceeded during any part of the working exposure.See ICSCs 0344 and 1222.