Unii-4u07f515LG; Eltrombopag Olamine; CAS 496775-62-3

Price	USD10.00
Packge	1kg

Min. Order:20kg
Supply Ability:500tons
Time:2022-06-28

Product Details

Product NameEltrombopag Olamine
CAS No.496775-62-3
EINECS No.629-876-8
MFC27H29N5O5
MW503.56
AppearancePowder
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C

Basic Info.

Colour

White

Samples

Available

Purity

99%

Certificates

ISO9001/SGS

Package

1kg/5kg/10kg/25kg

Stocks

in Stock

Lead Time

5-7 Working Days

Shelf Life

2-3 Years

Site Audit

Available

Transport

Air/Express/Sea

MOQ

10g

Transport Package

Drum/Bottle/Bags

Product Description

Unii-4U07F515lg;Eltrombopag olamine;CAS 496775-62-3

Unii-4U07F515lg Chemical Properties

storage temp.

Keep in dark place,Inert atmosphere,2-8°C

Safety Information

MSDS Information

Unii-4U07F515lg Usage And Synthesis

Uses	Treatment of chemotherapy-induced thrombocytopenia and treatment of immune thrombocytopenic purpura.
Clinical Use	Eltrombopag olamine, a thrombopoietin receptor (TpoR) agonist, was approved in late 2008 for the once-daily, oral short-term and long-term treatment of adult patients with previously treated chronic idiopathic thrombocytopenic purpura (ITP). It is the first small-molecule TpoR agonist and was launched in the U.S. for this indication in 2009 by GlaxoSmithKline (GSK). Because eltrombopag is a small molecule, the drug is administered orally and has a reduced potential for causing an immune system reaction versus alternative protein-based therapies. In 2010, eltrombopag was approved in Europe for the long-term treatment of adult patients with previously treated chronic ITP.
Chemical Synthesis	The synthesis began with the nitration of 2-bro mophenol (39) with sodi um nitrate and sulfuric acid in water at 10°C to give 2-bromo-6-nitrophenol (40) in 25% yield, which was methylated using met hyl iodide and potassium carbonate in refluxing aceto ne providing 2-bromo- 6-nitroanisole (41) in 76% yield (the Scheme).40 Suzuki coupling of compound 41 with 3-carboxyphenyl boronic acid with Pd(PPh3)4 and 2 M sodium carbonate in refluxing dio xane gave 20-methoxy- 30-nitrobiphenyl-3-carboxylic acid (42) in 47% yield as a tan powder. Demethylation using 48% HBr (aq) in refluxing acetic acid resulted in a 79% yield of 20-hydroxy-30-nitrobiphenyl-3-carboxylic acid (43). The nitro group of compound 43 was reduced via catalytic hydrogenation at 50 psi at room temperature over Pd/C in mixed ethanol/3 M aq NaOH solution to give 30-amino-20-hydroxybiphenyl- 3-carboxylic acid (44) in quantitative yield. The intermediate 1-(3,4-dimethylphenyl)-3-methyl-2,5-dihydro-1Hpyrazol- 5-one (47) was prepared by condensing of 3,4-dimethylphenyl- hydrazine 45 with ethyl acetoacetate 46 with sodium acetate in refluxing acetic acid in 76% yield. Treatment of (44) with sod ium nitrite in 1 M HCl at 5°C, followed by condensation with 1-(3,4-dimethylphenyl)-3-methyl-2,5-dihydro-1H-pyrazol-5-one (47) at a constant pH of 7-8 via the addition of sodium bicarbonate and ethanol afforded eltrombopag in 32% yield. Finally, eltrombopag was treated with hydroxyl ethyla mine to give eltrombopag olamine (VIII).

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2025-04-22

Hebei Linwo New Material Technology Co., LTD

Hebei China

Since:2022-03-18
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