99% CAS 59-05-2 Methotrexate Powder High Purity

Price	USD15.00
Packge	1kg

Min. Order:10kg
Supply Ability:20tons
Time:2022-06-28

Product Details

Product NameMethotrexate
CAS No.59-05-2
EINECS No.200-413-8
MFC20H22N8O5
MW454.45
InChIKeyFBOZXECLQNJBKD-VHLFKADZNA-N
AppearancepowderLight yellow to yellow
Water Solubility Insoluble. <0.1 g/100 mL at 19 ºC
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Melting point 195°C
Boiling point 561.26°C (rough estimate)
density 1.4080 (rough estimate)

Basic Info.

Grade

Pharmaceutcial Grade

CAS

59-05-2

Storage

Cool Dry Place

Deliver Time

5-10 Days

Appearance

Yellow Powder

Test Method

HPLC UV

Sample

Available

Shipping Method

Air(UPS, FedEx, TNT, EMS) or Sea

C20h22n8o5

Einecs No.

200-413-8

454.44

Refractive Index

1.6910 (Estimate)

Density

1.4080 (Rough Estimate)

Transport Package

Bag or Drum

Specification

1kg/bag 25kg/drum

Origin

China

Production Capacity

10000kg/Months

Product Description

Name	Methotrexate
Synonyms	(+)-Amethopterin; (+)-4-Amino-10-methylfolic acid; N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamic acid
Molecular Formula	C20H22N8O5
Molecular Weight	454.44
CAS Registry Number	59-05-2
EINECS	200-413-8

Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate arrests the cell cycle in late G1/S-phase, therefore inhibiting the synthesis of DNA, RNA, thymidylates, and proteins. In the previous cases the inhibition of enzymes involved in purine metabolism, leading to accumulation of adenosine, or the suppression of intercellular adhesion molecule expression by T cells as the main mechanism of action by methotrexate. The compound has been observed to irreversibly inhibit dihydrofolate reductase (DHFR) and thymidylate synthetase (TS). Methotrexate has been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. In adherent splenic cells, IL-1 production was decreased by methorexate.

Packaging & Shipping

Company Profile Introduction

New material technology research and development、Technology popularization、 Technical consulting、Technology transfer、Medical technology r&d

Recommended supplier

Jai Radhe Sales
Methotrexate Powder API MANUFACTURER INDIA
Inquiry
2025-09-23

Hebei Linwo New Material Technology Co., LTD

Hebei China

Since:2022-03-18
Address: Room 601, Unit 1, Building 1, 188 Xinhuali, North Xinhua Road, Xiangdu District, Xingtai city, Hebei

INQUIRY