Methazolamide
| Price | USD100.00 |
| Packge | 1kg |
- Min. Order:1kg
- Supply Ability:5000 Ton
- Time:2022-08-13
Product Details
- Product NameMethazolamide
- CAS No.554-57-4
- EINECS No.209-066-7
- MFC5H8N4O3S2
- MW236.27
- AppearanceWhite powderwhite to beige
- Melting point 208 °C (dec.) (lit.)
- storage temp. 2-8°C
- density 1.6625 (rough estimate)
- Boiling point 402.0±28.0 °C(Predicted)
- Water Solubility 2.835g/L(25 ºC)
Methazolamide is a carbonic anhydrase inhibitor (IC50 = 130 nM). It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and reduces cerebral edema in a mouse model of SAH. Methazolamide is larvicidal, with a larvicidal concentration (LC50) value of 724 ppm, but has no activity when administered in the diet to adult A. aegypti. Formulations containing methazolamide have been used for the treatment of glaucoma.
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